{"doi":"10.1038/ni931","title":"SOCS3 negatively regulates IL-6 signaling in vivo","abstract":null,"journal":"Nature Immunology","year":2003,"id":679291,"datarank":1.0112551041978084,"base_score":6.741700694652055,"endowment":6.741700694652055,"self_citation_contribution":1.0112551041978084,"citation_network_contribution":0.0,"self_endowment_contribution":1.0112551041978084,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":846,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1774824,"name":"Danielle L Krebs","orcid":null,"position":1,"is_corresponding":false},{"id":1715726,"name":"Jian-Guo Zhang","orcid":null,"position":2,"is_corresponding":false},{"id":1774825,"name":"Sam Wormald","orcid":null,"position":3,"is_corresponding":false},{"id":1774826,"name":"Tracy A Willson","orcid":null,"position":4,"is_corresponding":false},{"id":868342,"name":"Edouard G Stanley","orcid":null,"position":5,"is_corresponding":false},{"id":1774827,"name":"Lorraine Robb","orcid":null,"position":6,"is_corresponding":false},{"id":1774828,"name":"Christopher J Greenhalgh","orcid":null,"position":7,"is_corresponding":false},{"id":1298934,"name":"Irmgard Förster","orcid":"0000-0002-7644-5642","position":8,"is_corresponding":false},{"id":1774829,"name":"Björn E Clausen","orcid":null,"position":9,"is_corresponding":false},{"id":1774830,"name":"Nicos A Nicola","orcid":null,"position":10,"is_corresponding":false},{"id":287143,"name":"Donald Metcalf","orcid":null,"position":11,"is_corresponding":false},{"id":1728381,"name":"Douglas J Hilton","orcid":null,"position":12,"is_corresponding":false},{"id":1774831,"name":"Andrew W Roberts","orcid":null,"position":13,"is_corresponding":false},{"id":1774832,"name":"Warren S Alexander","orcid":null,"position":14,"is_corresponding":false},{"id":1774823,"name":"Ben A Croker","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"SOCS3 negatively regulates IL-6 signaling in vivo","abstract":"Members of the suppressor of cytokine signaling (SOCS) family are potentially key physiological negative regulators of interleukin-6 (IL-6) signaling. To examine whether SOCS3 is involved in regulating this signaling, we have used conditional gene targeting to generate mice lacking Socs3 in the liver or in macrophages. We show that Socs3 deficiency results in prolonged activation of signal transducer and activator of transcription 1 (STAT1) and STAT3 after IL-6 stimulation but normal activation of STAT1 after stimulation with interferon-gamma (IFN-gamma). Conversely, IL-6-induced STAT activation is normal in Socs1-deficient cells, whereas STAT1 activation induced by IFN-gamma is prolonged. Microarray analysis shows that the pattern of gene expression induced by IL-6 in Socs3-deficient livers mimics that induced by IFN-gamma. Our data indicate that SOCS3 and SOCS1 have reciprocal functions in IL-6 and IFN-gamma regulation and imply that SOCS3 has a role in preventing IFN-gamma-like responses in cells stimulated by IL-6.","is_dataset_classified":null,"base_score":6.741700694652055,"endowment":6.741700694652055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12754505","pmcid":null,"openalex_id":"https://openalex.org/W2147495692","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"CA22556","title":null}],"total_grants":1,"fwci":21.8407,"citation_percentile":0.99804121,"influential_citations":0,"citation_trend":[{"year":2012,"count":54},{"year":2013,"count":42},{"year":2014,"count":38},{"year":2015,"count":24},{"year":2016,"count":43},{"year":2017,"count":33},{"year":2018,"count":32},{"year":2019,"count":39},{"year":2020,"count":31},{"year":2021,"count":46},{"year":2022,"count":17},{"year":2023,"count":26},{"year":2024,"count":29},{"year":2025,"count":19},{"year":2026,"count":14}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://www.nature.com/articles/ni931.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/ni931","host_type":"publisher"},{"url":"https://doi.org/10.1038/ni931","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12754505","host_type":"repository"},{"url":"https://pure.amsterdamumc.nl/en/publications/3b03d526-f06f-4af7-9cd9-375b5a770355","host_type":"repository"},{"url":"https://pure.amc.nl/en/publications/socs3-negatively-regulates-il6-signaling-in-vivo(689faaab-8203-46a6-aacd-17a4daf457f5).html","host_type":"repository"},{"url":"https://mediatum.ub.tum.de/1332447","host_type":"repository"}],"fields_of_study":["Cytokine Signaling Pathways and Interactions","interferon and immune responses","Pharmacological Effects of Natural Compounds","Animals","Carrier Proteins","DNA-Binding Proteins","Female","Interferon-gamma","Interleukin-10","Interleukin-6","Liver","Macrophages","Male","Mice","Mice, Inbred BALB C","Mice, Inbred C57BL","Mice, Knockout","Oligonucleotide Array Sequence Analysis","Phosphorylation","Polymerase Chain Reaction","Proteins","Repressor Proteins","STAT3 Transcription Factor","Signal Transduction","Suppressor of Cytokine Signaling 1 Protein","Suppressor of Cytokine Signaling 3 Protein","Suppressor of Cytokine Signaling Proteins","Trans-Activators","Transcription Factors","Transcription, Genetic"],"mesh_terms":["Suppressor of Cytokine Signaling 1 Protein","Suppressor of Cytokine Signaling 3 Protein","Animals","Carrier Proteins","DNA-Binding Proteins","Female","Interferon-gamma","Liver","Macrophages","Male","Mice, Inbred BALB C","Mice, Inbred C57BL","Phosphorylation","Proteins","Repressor Proteins","Transcription Factors","Transcription, Genetic","Signal Transduction","Trans-Activators","Interleukin-6","Polymerase Chain Reaction","Interleukin-10","Mice, Knockout","Oligonucleotide Array Sequence Analysis","STAT3 Transcription Factor","Suppressor of Cytokine Signaling Proteins","Mice"],"keywords":["SOCS3","Suppressor of cytokine signaling 1","STAT protein","STAT1","Signal transduction","Biology","Cell biology","STAT3","Cytokine","Suppressor of cytokine signalling","SOCS6","stat","SOCS5","Stimulation","Immunology","Gene expression","Gene","Suppressor","Endocrinology","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T12:46:44.906372Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}