{"doi":"10.1038/ng.2411","title":"Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions","abstract":null,"journal":"Nature Genetics","year":2012,"id":592686,"datarank":10.594970203769961,"base_score":5.62040086571715,"endowment":5.62040086571715,"self_citation_contribution":0.8430601298575726,"citation_network_contribution":9.751910073912388,"self_endowment_contribution":0.8430601298575726,"citer_contribution":9.751910073912388,"corpus_percentile":null,"corpus_rank":null,"citation_count":275,"citer_count":200,"citers_with_citation_signal":192,"citers_with_endowment":192,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":264806,"name":"Peter Kraft","orcid":"0000-0002-4472-8103","position":1,"is_corresponding":false},{"id":1516687,"name":"Kan Zhai","orcid":null,"position":2,"is_corresponding":false},{"id":1024297,"name":"Jiang Chang","orcid":"0000-0001-8551-9458","position":3,"is_corresponding":false},{"id":323471,"name":"Zhaoming Wang","orcid":"0000-0001-9085-5704","position":4,"is_corresponding":false},{"id":1052732,"name":"Yun Li","orcid":"0000-0002-1092-9839","position":5,"is_corresponding":false},{"id":893671,"name":"Zhibin Hu","orcid":null,"position":6,"is_corresponding":false},{"id":1337973,"name":"Zhonghu He","orcid":"0000-0003-1384-3712","position":7,"is_corresponding":false},{"id":1516688,"name":"Weihua Jia","orcid":null,"position":8,"is_corresponding":false},{"id":1516689,"name":"Christian C Abnet","orcid":null,"position":9,"is_corresponding":false},{"id":35194,"name":"Liming Liang","orcid":"0000-0001-8261-3174","position":10,"is_corresponding":false},{"id":308604,"name":"Nan Hu","orcid":"0000-0003-1443-2130","position":11,"is_corresponding":false},{"id":4913,"name":"Xiaoping Miao","orcid":"0000-0001-6732-8367","position":12,"is_corresponding":false},{"id":608063,"name":"Yifeng Zhou","orcid":"0000-0003-1847-7985","position":13,"is_corresponding":false},{"id":314274,"name":"Zhihua Liu","orcid":"0000-0003-4242-033X","position":14,"is_corresponding":false},{"id":201545,"name":"Qimin Zhan","orcid":null,"position":15,"is_corresponding":false},{"id":511400,"name":"Yu Liu","orcid":"0000-0002-4789-0288","position":16,"is_corresponding":false},{"id":1026963,"name":"Yan Qiao","orcid":"0000-0002-5005-5996","position":17,"is_corresponding":false},{"id":1516690,"name":"Yuling Zhou","orcid":null,"position":18,"is_corresponding":false},{"id":31997,"name":"Guangfu Jin","orcid":"0000-0003-0249-5337","position":19,"is_corresponding":false},{"id":1516691,"name":"Chuanhai Guo","orcid":null,"position":20,"is_corresponding":false},{"id":1516692,"name":"Changdong Lu","orcid":null,"position":21,"is_corresponding":false},{"id":240168,"name":"Haijun Yang","orcid":"0000-0002-2962-8980","position":22,"is_corresponding":false},{"id":879541,"name":"Jianhua Fu","orcid":"0009-0003-4485-6214","position":23,"is_corresponding":false},{"id":374630,"name":"Dianke Yu","orcid":"0000-0002-2031-3683","position":24,"is_corresponding":false},{"id":1516693,"name":"Neal D Freedman","orcid":null,"position":25,"is_corresponding":false},{"id":838457,"name":"Ti Ding","orcid":null,"position":26,"is_corresponding":false},{"id":1360975,"name":"Wen Tan","orcid":"0000-0002-7231-7838","position":27,"is_corresponding":false},{"id":133246,"name":"Alisa M Goldstein","orcid":null,"position":28,"is_corresponding":false},{"id":442285,"name":"Tangchun Wu","orcid":"0000-0001-9931-5106","position":29,"is_corresponding":false},{"id":251851,"name":"Hongbing Shen","orcid":"0000-0002-2581-5906","position":30,"is_corresponding":false},{"id":1516698,"name":"Yang Ke","orcid":null,"position":31,"is_corresponding":false},{"id":1516699,"name":"Yixin Zeng","orcid":null,"position":32,"is_corresponding":false},{"id":1356929,"name":"Stephen J Chanock","orcid":null,"position":33,"is_corresponding":false},{"id":1516700,"name":"Philip R Taylor","orcid":null,"position":34,"is_corresponding":false},{"id":498894,"name":"Dongxin Lin","orcid":"0000-0002-8723-8868","position":35,"is_corresponding":false},{"id":663556,"name":"Chen Wu","orcid":"0000-0002-2817-7161","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions","abstract":"We conducted a genome-wide association study (GWAS) and a genome-wide gene-environment interaction analysis of esophageal squamous-cell carcinoma (ESCC) in 2,031 affected individuals (cases) and 2,044 controls with independent validation in 8,092 cases and 8,620 controls. We identified nine new ESCC susceptibility loci, of which seven, at chromosomes 4q23, 16q12.1, 17q21, 22q12, 3q27, 17p13 and 18p11, had a significant marginal effect (P=1.78×10(-39) to P=2.49×10(-11)) and two of which, at 2q22 and 13q33, had a significant association only in the gene-alcohol drinking interaction (gene-environment interaction P (PG×E)=4.39×10(-11) and PG×E=4.80×10(-8), respectively). Variants at the 4q23 locus, which includes the ADH cluster, each had a significant interaction with alcohol drinking in their association with ESCC risk (PG×E=2.54×10(-7) to PG×E=3.23×10(-2)). We confirmed the known association of the ALDH2 locus on 12q24 to ESCC, and a joint analysis showed that drinkers with both of the ADH1B and ALDH2 risk alleles had a fourfold increased risk for ESCC compared to drinkers without these risk alleles. Our results underscore the direct genetic contribution to ESCC risk, as well as the genetic contribution to ESCC through interaction with alcohol consumption.","is_dataset_classified":null,"base_score":5.62040086571715,"endowment":5.62040086571715,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22960999","pmcid":null,"openalex_id":"https://openalex.org/W1991704009","authors":[],"funders":[],"total_grants":0,"fwci":25.7855,"citation_percentile":0.99794933,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":22},{"year":2014,"count":38},{"year":2015,"count":30},{"year":2016,"count":22},{"year":2017,"count":21},{"year":2018,"count":21},{"year":2019,"count":22},{"year":2020,"count":19},{"year":2021,"count":15},{"year":2022,"count":16},{"year":2023,"count":15},{"year":2024,"count":14},{"year":2025,"count":12},{"year":2026,"count":6}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://www.nature.com/articles/ng.2411.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/ng.2411","host_type":"publisher"},{"url":"https://doi.org/10.1038/ng.2411","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22960999","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3513832","host_type":"repository"}],"fields_of_study":["Esophageal Cancer Research and Treatment","RNA modifications and cancer","Cancer-related gene regulation","Adult","Aged","Alcohol Dehydrogenase","Alcohol Drinking","Aldehyde Dehydrogenase","Aldehyde Dehydrogenase, Mitochondrial","Alleles","Asian People","Carcinoma, Squamous Cell","Case-Control Studies","Esophageal Neoplasms","Female","Gene-Environment Interaction","Genetic Loci","Genetic Predisposition to Disease","Genome-Wide Association Study","Humans","Male","Middle Aged","Polymorphism, Single Nucleotide","Risk Factors"],"mesh_terms":["Aldehyde Dehydrogenase, Mitochondrial","Adult","Aged","Alcohol Dehydrogenase","Alcohol Drinking","Aldehyde Dehydrogenase","Alleles","Carcinoma, Squamous Cell","Esophageal Neoplasms","Female","Humans","Male","Middle Aged","Risk Factors","Case-Control Studies","Genetic Predisposition to Disease","Polymorphism, Single Nucleotide","Asian People","Genome-Wide Association Study","Genetic Loci","Gene-Environment Interaction"],"keywords":["Genome-wide association study","Biology","Esophageal squamous cell carcinoma","Genetics","Locus (genetics)","Allele","ALDH2","Genetic association","Gene","ADH1B","Genotype","Single-nucleotide polymorphism","Carcinoma"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T14:57:45.546472Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}