{"doi":"10.1038/ng.2385","title":"Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways","abstract":null,"journal":"Nature Genetics","year":2012,"id":606216,"datarank":1.0140622036625142,"base_score":6.760414691083428,"endowment":6.760414691083428,"self_citation_contribution":1.0140622036625142,"citation_network_contribution":0.0,"self_endowment_contribution":1.0140622036625142,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":862,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":593361,"name":"Vasiliki Lagou","orcid":"0000-0003-3165-8940","position":1,"is_corresponding":false},{"id":1556045,"name":"Ryan P Welch","orcid":null,"position":2,"is_corresponding":false},{"id":51457,"name":"Eleanor Wheeler","orcid":"0000-0002-8616-6444","position":3,"is_corresponding":false},{"id":1552653,"name":"May E Montasser","orcid":null,"position":4,"is_corresponding":false},{"id":21670,"name":"Jian'an Luan","orcid":null,"position":5,"is_corresponding":false},{"id":14660,"name":"Reedik Mägi","orcid":"0000-0002-2964-6011","position":6,"is_corresponding":false},{"id":1529696,"name":"Rona J Strawbridge","orcid":null,"position":7,"is_corresponding":false},{"id":603489,"name":"Emil Rehnberg","orcid":"0000-0002-5318-5139","position":8,"is_corresponding":false},{"id":21667,"name":"Stefan Gustafsson","orcid":"0000-0001-5894-0351","position":9,"is_corresponding":false},{"id":21702,"name":"Stavroula Kanoni","orcid":"0000-0002-1691-9615","position":10,"is_corresponding":false},{"id":1552654,"name":"Laura J Rasmussen-Torvik","orcid":null,"position":11,"is_corresponding":false},{"id":21726,"name":"Loïc Yengo","orcid":"0000-0002-4272-9305","position":12,"is_corresponding":false},{"id":1552651,"name":"Cecile Lecoeur","orcid":null,"position":13,"is_corresponding":false},{"id":21716,"name":"Dmitry Shungin","orcid":"0000-0001-7900-5856","position":14,"is_corresponding":false},{"id":21821,"name":"Serena Sanna","orcid":"0000-0002-3768-1749","position":15,"is_corresponding":false},{"id":218093,"name":"Carlo Sidore","orcid":"0000-0001-7504-7477","position":16,"is_corresponding":false},{"id":1552682,"name":"Paul C D Johnson","orcid":null,"position":17,"is_corresponding":false},{"id":1552683,"name":"J Wouter Jukema","orcid":null,"position":18,"is_corresponding":false},{"id":32950,"name":"Toby Johnson","orcid":"0000-0002-5998-3270","position":19,"is_corresponding":false},{"id":21799,"name":"Anubha Mahajan","orcid":"0000-0001-5585-3420","position":20,"is_corresponding":false},{"id":21845,"name":"Niek Verweij","orcid":"0000-0002-4303-7685","position":21,"is_corresponding":false},{"id":21838,"name":"Gudmar Thorleifsson","orcid":null,"position":22,"is_corresponding":false},{"id":5234,"name":"Jouke-Jan Hottenga","orcid":null,"position":23,"is_corresponding":false},{"id":95992,"name":"Sonia Shah","orcid":"0000-0001-5860-4526","position":24,"is_corresponding":false},{"id":1549349,"name":"Albert V Smith","orcid":null,"position":25,"is_corresponding":false},{"id":603490,"name":"Bengt Sennblad","orcid":"0000-0002-4360-8003","position":26,"is_corresponding":false},{"id":2351,"name":"Christian Gieger","orcid":"0000-0001-6986-9554","position":27,"is_corresponding":false},{"id":603491,"name":"Perttu Salo","orcid":"0000-0003-0265-0173","position":28,"is_corresponding":false},{"id":21973,"name":"Markus Perola","orcid":"0000-0003-4842-1667","position":29,"is_corresponding":false},{"id":1556047,"name":"Nicholas J Timpson","orcid":null,"position":30,"is_corresponding":false},{"id":78828,"name":"David M Evans","orcid":null,"position":31,"is_corresponding":false},{"id":118049,"name":"Beate St Pourcain","orcid":null,"position":32,"is_corresponding":false},{"id":589658,"name":"Ying Wu","orcid":"0000-0002-6657-423X","position":33,"is_corresponding":false},{"id":1552656,"name":"Jeanette S Andrews","orcid":null,"position":34,"is_corresponding":false},{"id":268137,"name":"Jennie Hui","orcid":"0000-0002-1653-2496","position":35,"is_corresponding":false},{"id":1552649,"name":"Lawrence F Bielak","orcid":null,"position":36,"is_corresponding":false},{"id":525139,"name":"Wei Zhao","orcid":"0000-0001-9437-3198","position":37,"is_corresponding":false},{"id":21638,"name":"Momoko Horikoshi","orcid":"0000-0002-7103-2267","position":38,"is_corresponding":false},{"id":55343,"name":"Pau Navarro","orcid":"0000-0001-5576-8584","position":39,"is_corresponding":false},{"id":21780,"name":"Aaron Isaacs","orcid":"0000-0001-5037-4834","position":40,"is_corresponding":false},{"id":217195,"name":"Jeffrey R O'Connell","orcid":null,"position":41,"is_corresponding":false},{"id":21832,"name":"Kathleen Stirrups","orcid":"0000-0002-6823-3252","position":42,"is_corresponding":false},{"id":1527801,"name":"Veronique Vitart","orcid":null,"position":43,"is_corresponding":false},{"id":5331,"name":"Caroline Hayward","orcid":"0000-0002-9405-9550","position":44,"is_corresponding":false},{"id":1054,"name":"Tõnu Esko","orcid":null,"position":45,"is_corresponding":false},{"id":5257,"name":"Evelin Mihailov","orcid":null,"position":46,"is_corresponding":false},{"id":1529622,"name":"Ross M Fraser","orcid":null,"position":47,"is_corresponding":false},{"id":351262,"name":"Tove Fall","orcid":"0000-0003-2071-5866","position":48,"is_corresponding":false},{"id":1518053,"name":"Benjamin F Voight","orcid":null,"position":49,"is_corresponding":false},{"id":35259,"name":"Soumya Raychaudhuri","orcid":"0000-0002-1901-8265","position":50,"is_corresponding":false},{"id":238075,"name":"Han Chen","orcid":"0000-0002-1722-8736","position":51,"is_corresponding":false},{"id":1529663,"name":"Cecilia M Lindgren","orcid":null,"position":52,"is_corresponding":false},{"id":1518051,"name":"Andrew P Morris","orcid":null,"position":53,"is_corresponding":false},{"id":1556050,"name":"Nigel W Rayner","orcid":null,"position":54,"is_corresponding":false},{"id":413745,"name":"Neil Robertson","orcid":"0000-0003-1691-5531","position":55,"is_corresponding":false},{"id":90095,"name":"Denis Rybin","orcid":"0000-0002-3657-4829","position":56,"is_corresponding":false},{"id":130878,"name":"Ching-Ti Liu","orcid":null,"position":57,"is_corresponding":false},{"id":21998,"name":"Jacques S Beckmann","orcid":null,"position":58,"is_corresponding":false},{"id":1552800,"name":"Sara M Willems","orcid":null,"position":59,"is_corresponding":false},{"id":1513551,"name":"Peter S Chines","orcid":null,"position":60,"is_corresponding":false},{"id":1513547,"name":"Anne U Jackson","orcid":null,"position":61,"is_corresponding":false},{"id":24782,"name":"Hyun Min Kang","orcid":"0000-0002-3631-3979","position":62,"is_corresponding":false},{"id":1513550,"name":"Heather M Stringham","orcid":null,"position":63,"is_corresponding":false},{"id":1509661,"name":"Kijoung Song","orcid":null,"position":64,"is_corresponding":false},{"id":21720,"name":"Toshiko Tanaka","orcid":"0000-0002-4161-3829","position":65,"is_corresponding":false},{"id":1552741,"name":"John F Peden","orcid":null,"position":66,"is_corresponding":false},{"id":21699,"name":"Anuj Goel","orcid":"0000-0003-2307-4021","position":67,"is_corresponding":false},{"id":1552679,"name":"Andrew A Hicks","orcid":null,"position":68,"is_corresponding":false},{"id":344609,"name":"Ping An","orcid":"0000-0002-5322-3510","position":69,"is_corresponding":false},{"id":21811,"name":"Martina Müller-Nurasyid","orcid":null,"position":70,"is_corresponding":false},{"id":1556058,"name":"Anders Franco-Cereceda","orcid":null,"position":71,"is_corresponding":false},{"id":21757,"name":"Lasse Folkersen","orcid":"0000-0003-0708-9530","position":72,"is_corresponding":false},{"id":605927,"name":"Letizia Marullo","orcid":null,"position":73,"is_corresponding":false},{"id":1556059,"name":"Hanneke Jansen","orcid":null,"position":74,"is_corresponding":false},{"id":1556060,"name":"Albertine J Oldehinkel","orcid":null,"position":75,"is_corresponding":false},{"id":21740,"name":"Marcel Bruinenberg","orcid":null,"position":76,"is_corresponding":false},{"id":1198475,"name":"James S Pankow","orcid":null,"position":77,"is_corresponding":false},{"id":126561,"name":"Kari E North","orcid":null,"position":78,"is_corresponding":false},{"id":1529620,"name":"Nita G Forouhi","orcid":null,"position":79,"is_corresponding":false},{"id":1518050,"name":"Ruth J F Loos","orcid":null,"position":80,"is_corresponding":false},{"id":65251,"name":"Sarah Edkins","orcid":"0000-0003-0717-1972","position":81,"is_corresponding":false},{"id":1556063,"name":"Tibor V Varga","orcid":null,"position":82,"is_corresponding":false},{"id":22025,"name":"Göran Hallmans","orcid":"0000-0001-9581-3845","position":83,"is_corresponding":false},{"id":1556067,"name":"Heikki Oksa","orcid":null,"position":84,"is_corresponding":false},{"id":1556070,"name":"Mulas Antonella","orcid":null,"position":85,"is_corresponding":false},{"id":593294,"name":"Ramaiah Nagaraja","orcid":"0000-0003-0915-2441","position":86,"is_corresponding":false},{"id":21721,"name":"Stella Trompet","orcid":"0000-0001-5006-0528","position":87,"is_corresponding":false},{"id":1396802,"name":"Ian Ford","orcid":"0000-0002-3236-5739","position":88,"is_corresponding":false},{"id":1556073,"name":"Stephan J L Bakker","orcid":null,"position":89,"is_corresponding":false},{"id":7034,"name":"Augustine Kong","orcid":"0000-0001-8193-5438","position":90,"is_corresponding":false},{"id":215351,"name":"Meena Kumari","orcid":null,"position":91,"is_corresponding":false},{"id":50026,"name":"Bruna Gigante","orcid":"0000-0003-4508-7990","position":92,"is_corresponding":false},{"id":19631,"name":"Christian Herder","orcid":"0000-0002-2050-093X","position":93,"is_corresponding":false},{"id":1556074,"name":"Patricia B Munroe","orcid":null,"position":94,"is_corresponding":false},{"id":1529606,"name":"Mark Caulfield","orcid":null,"position":95,"is_corresponding":false},{"id":1556075,"name":"Jula Antti","orcid":null,"position":96,"is_corresponding":false},{"id":21708,"name":"Massimo Mangino","orcid":"0000-0002-2167-7470","position":97,"is_corresponding":false},{"id":1514830,"name":"Kerrin Small","orcid":null,"position":98,"is_corresponding":false},{"id":308332,"name":"Iva Miljkovic","orcid":"0000-0002-3155-9777","position":99,"is_corresponding":false},{"id":1128040,"name":"Yongmei Liu","orcid":"0000-0002-6342-5407","position":100,"is_corresponding":false},{"id":162188,"name":"Mustafa Atalay","orcid":null,"position":101,"is_corresponding":false},{"id":216245,"name":"Wieland Kiess","orcid":null,"position":102,"is_corresponding":false},{"id":21781,"name":"Alan L James","orcid":null,"position":103,"is_corresponding":false},{"id":16431,"name":"Fernando Rivadeneira","orcid":"0000-0001-9435-9441","position":104,"is_corresponding":false},{"id":34118,"name":"Andre G Uitterlinden","orcid":null,"position":105,"is_corresponding":false},{"id":1529675,"name":"Colin N A Palmer","orcid":null,"position":106,"is_corresponding":false},{"id":1529616,"name":"Alex S F Doney","orcid":null,"position":107,"is_corresponding":false},{"id":5313,"name":"Gonneke Willemsen","orcid":"0000-0003-3755-0236","position":108,"is_corresponding":false},{"id":1517751,"name":"Johannes H Smit","orcid":null,"position":109,"is_corresponding":false},{"id":627034,"name":"Susan Campbell","orcid":null,"position":110,"is_corresponding":false},{"id":887449,"name":"Ozren Polasek","orcid":null,"position":111,"is_corresponding":false},{"id":1529603,"name":"Lori L Bonnycastle","orcid":null,"position":112,"is_corresponding":false},{"id":1552678,"name":"Serge Hercberg","orcid":null,"position":113,"is_corresponding":false},{"id":21752,"name":"Maria Dimitriou","orcid":"0000-0002-8469-8068","position":114,"is_corresponding":false},{"id":1556082,"name":"Jennifer L Bolton","orcid":null,"position":115,"is_corresponding":false},{"id":1556083,"name":"Gerard R Fowkes","orcid":null,"position":116,"is_corresponding":false},{"id":21904,"name":"Peter Kovacs","orcid":null,"position":117,"is_corresponding":false},{"id":21794,"name":"Jaana Lindström","orcid":"0000-0001-9255-020X","position":118,"is_corresponding":false},{"id":528885,"name":"Tatijana Zemunik","orcid":"0000-0001-8120-2891","position":119,"is_corresponding":false},{"id":21731,"name":"Stefania Bandinelli","orcid":"0000-0002-6491-0850","position":120,"is_corresponding":false},{"id":1552798,"name":"Sarah H Wild","orcid":null,"position":121,"is_corresponding":false},{"id":1556084,"name":"Hanneke V Basart","orcid":null,"position":122,"is_corresponding":false},{"id":19621,"name":"Wolfgang Rathmann","orcid":"0000-0001-7804-1740","position":123,"is_corresponding":false},{"id":2352,"name":"Harald Grallert","orcid":"0000-0002-6876-9655","position":124,"is_corresponding":false},{"id":862427,"name":"Winfried Maerz","orcid":null,"position":126,"is_corresponding":false},{"id":1556085,"name":"Marcus E Kleber","orcid":null,"position":127,"is_corresponding":false},{"id":1529601,"name":"Bernhard O Boehm","orcid":null,"position":128,"is_corresponding":false},{"id":2343,"name":"Annette Peters","orcid":"0000-0001-6645-0985","position":129,"is_corresponding":false},{"id":1552758,"name":"Peter P Pramstaller","orcid":null,"position":130,"is_corresponding":false},{"id":1552760,"name":"Michael A Province","orcid":null,"position":131,"is_corresponding":false},{"id":1552660,"name":"Ingrid B Borecki","orcid":null,"position":132,"is_corresponding":false},{"id":1556086,"name":"Nicholas D Hastie","orcid":null,"position":133,"is_corresponding":false},{"id":21932,"name":"Igor Rudan","orcid":"0000-0001-6993-6884","position":134,"is_corresponding":false},{"id":227075,"name":"Harry Campbell","orcid":"0000-0002-6169-6262","position":135,"is_corresponding":false},{"id":1130,"name":"Hugh Watkins","orcid":"0000-0002-5287-9016","position":136,"is_corresponding":false},{"id":21871,"name":"Martin Farrall","orcid":"0000-0003-4564-2165","position":137,"is_corresponding":false},{"id":1552779,"name":"Michael Stumvoll","orcid":null,"position":138,"is_corresponding":false},{"id":21956,"name":"Luigi Ferrucci","orcid":"0000-0002-6273-1613","position":139,"is_corresponding":false},{"id":1552792,"name":"Dawn M Waterworth","orcid":null,"position":140,"is_corresponding":false},{"id":1529600,"name":"Richard N Bergman","orcid":null,"position":141,"is_corresponding":false},{"id":139250,"name":"Francis S Collins","orcid":null,"position":142,"is_corresponding":false},{"id":1165,"name":"Jaakko Tuomilehto","orcid":"0000-0002-8306-6202","position":143,"is_corresponding":false},{"id":1513558,"name":"Richard M Watanabe","orcid":null,"position":144,"is_corresponding":false},{"id":1556087,"name":"Eco J C de Geus","orcid":null,"position":145,"is_corresponding":false},{"id":1556088,"name":"Brenda W Penninx","orcid":null,"position":146,"is_corresponding":false},{"id":21890,"name":"Albert Hofman","orcid":"0000-0002-9865-121X","position":147,"is_corresponding":false},{"id":21972,"name":"Ben A Oostra","orcid":null,"position":148,"is_corresponding":false},{"id":1390483,"name":"Bruce M Psaty","orcid":null,"position":149,"is_corresponding":false},{"id":1552789,"name":"Peter Vollenweider","orcid":null,"position":150,"is_corresponding":false},{"id":1529699,"name":"James F Wilson","orcid":null,"position":151,"is_corresponding":false},{"id":1552804,"name":"Alan F Wright","orcid":null,"position":152,"is_corresponding":false},{"id":1556089,"name":"G Kees Hovingh","orcid":null,"position":153,"is_corresponding":false},{"id":213776,"name":"Andres Metspalu","orcid":"0000-0002-3718-796X","position":154,"is_corresponding":false},{"id":21985,"name":"Matti Uusitupa","orcid":"0000-0001-6052-2001","position":155,"is_corresponding":false},{"id":1552711,"name":"Patrik K E Magnusson","orcid":null,"position":156,"is_corresponding":false},{"id":1556090,"name":"Kirsten O Kyvik","orcid":null,"position":157,"is_corresponding":false},{"id":1070,"name":"Jaakko Kaprio","orcid":"0000-0002-3716-2455","position":158,"is_corresponding":false},{"id":1529682,"name":"Jackie F Price","orcid":null,"position":159,"is_corresponding":false},{"id":1552671,"name":"George V Dedoussis","orcid":null,"position":160,"is_corresponding":false},{"id":21991,"name":"Panos Deloukas","orcid":"0000-0001-9251-070X","position":161,"is_corresponding":false},{"id":1552714,"name":"Pierre Meneton","orcid":null,"position":162,"is_corresponding":false},{"id":21793,"name":"Lars Lind","orcid":"0000-0003-2335-8542","position":163,"is_corresponding":false},{"id":1035,"name":"Michael Boehnke","orcid":"0000-0002-6442-7754","position":164,"is_corresponding":false},{"id":1529693,"name":"Alan R Shuldiner","orcid":null,"position":165,"is_corresponding":false},{"id":1552655,"name":"Cornelia M van Duijn","orcid":null,"position":166,"is_corresponding":false},{"id":1529667,"name":"Andrew D Morris","orcid":null,"position":167,"is_corresponding":false},{"id":1556091,"name":"Anke Toenjes","orcid":null,"position":168,"is_corresponding":false},{"id":1552756,"name":"Patricia A Peyser","orcid":null,"position":169,"is_corresponding":false},{"id":1552658,"name":"John P Beilby","orcid":null,"position":170,"is_corresponding":false},{"id":271409,"name":"Antje Körner","orcid":"0000-0001-6001-0356","position":171,"is_corresponding":false},{"id":21907,"name":"Johanna Kuusisto","orcid":"0000-0001-6550-3176","position":172,"is_corresponding":false},{"id":277044,"name":"Markku Laakso","orcid":"0000-0002-3394-7749","position":173,"is_corresponding":false},{"id":1556092,"name":"Stefan R Bornstein","orcid":null,"position":174,"is_corresponding":false},{"id":1556093,"name":"Peter E H Schwarz","orcid":null,"position":175,"is_corresponding":false},{"id":1489957,"name":"Timo A Lakka","orcid":null,"position":176,"is_corresponding":false},{"id":243639,"name":"Rainer Rauramaa","orcid":null,"position":177,"is_corresponding":false},{"id":1529594,"name":"Linda S Adair","orcid":null,"position":178,"is_corresponding":false},{"id":1528,"name":"George Davey Smith","orcid":"0000-0002-1407-8314","position":179,"is_corresponding":false},{"id":840471,"name":"Tim D Spector","orcid":null,"position":180,"is_corresponding":false},{"id":2344,"name":"Thomas Illig","orcid":"0000-0003-4284-5389","position":181,"is_corresponding":false},{"id":1529614,"name":"Ulf de Faire","orcid":null,"position":182,"is_corresponding":false},{"id":21960,"name":"Anders Hamsten","orcid":null,"position":183,"is_corresponding":false},{"id":21881,"name":"Vilmundur Gudnason","orcid":null,"position":184,"is_corresponding":false},{"id":1552688,"name":"Mika Kivimaki","orcid":null,"position":185,"is_corresponding":false},{"id":1552680,"name":"Aroon Hingorani","orcid":null,"position":186,"is_corresponding":false},{"id":21902,"name":"Sirkka M Keinanen-Kiukaanniemi","orcid":null,"position":187,"is_corresponding":false},{"id":21980,"name":"Timo E Saaristo","orcid":null,"position":188,"is_corresponding":false},{"id":1201833,"name":"Dorret I Boomsma","orcid":null,"position":189,"is_corresponding":false},{"id":5356,"name":"Kari Stefansson","orcid":null,"position":190,"is_corresponding":false},{"id":21986,"name":"Pim van der Harst","orcid":"0000-0002-2713-686X","position":191,"is_corresponding":false},{"id":1051,"name":"Josée Dupuis","orcid":"0000-0003-2871-3603","position":192,"is_corresponding":false},{"id":1529676,"name":"Nancy L Pedersen","orcid":null,"position":193,"is_corresponding":false},{"id":42051,"name":"Naveed Sattar","orcid":"0000-0002-1604-2593","position":194,"is_corresponding":false},{"id":1424414,"name":"Tamara B Harris","orcid":null,"position":195,"is_corresponding":false},{"id":14679,"name":"Francesco Cucca","orcid":"0000-0002-7414-1995","position":196,"is_corresponding":false},{"id":1109,"name":"Samuli Ripatti","orcid":"0000-0002-0504-1202","position":197,"is_corresponding":false},{"id":1112,"name":"Veikko Salomaa","orcid":"0000-0001-7563-5324","position":198,"is_corresponding":false},{"id":1513559,"name":"Karen L Mohlke","orcid":null,"position":199,"is_corresponding":false},{"id":600736,"name":"Beverley Balkau","orcid":"0000-0003-2021-413X","position":200,"is_corresponding":false},{"id":21958,"name":"Philippe Froguel","orcid":"0000-0003-2972-0784","position":201,"is_corresponding":false},{"id":55348,"name":"Anneli Pouta","orcid":null,"position":202,"is_corresponding":false},{"id":269495,"name":"Marjo-Riitta Jarvelin","orcid":null,"position":203,"is_corresponding":false},{"id":1367775,"name":"Nicholas J Wareham","orcid":null,"position":204,"is_corresponding":false},{"id":584979,"name":"Nabila Bouatia-Naji","orcid":null,"position":205,"is_corresponding":false},{"id":1529707,"name":"Mark I McCarthy","orcid":null,"position":206,"is_corresponding":false},{"id":1552675,"name":"Paul W Franks","orcid":null,"position":207,"is_corresponding":false},{"id":1529666,"name":"James B Meigs","orcid":null,"position":208,"is_corresponding":false},{"id":1513552,"name":"Tanya M Teslovich","orcid":null,"position":209,"is_corresponding":false},{"id":677770,"name":"Jose C Florez","orcid":null,"position":210,"is_corresponding":false},{"id":21909,"name":"Claudia Langenberg","orcid":"0000-0002-5017-7344","position":211,"is_corresponding":false},{"id":22005,"name":"Erik Ingelsson","orcid":"0000-0003-2256-6972","position":212,"is_corresponding":false},{"id":21715,"name":"Inga Prokopenko","orcid":"0000-0003-1624-7457","position":213,"is_corresponding":false},{"id":21995,"name":"Inês Barroso","orcid":"0000-0001-5800-4520","position":214,"is_corresponding":false},{"id":1529690,"name":"Robert A Scott","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways","abstract":"Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control.","is_dataset_classified":null,"base_score":6.760414691083428,"endowment":6.760414691083428,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22885924","pmcid":"PMC3433394","openalex_id":"https://openalex.org/W2126237420","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"083948","title":null},{"funder_name":"Medical Research Council","grant_id":"85374","title":null},{"funder_name":"Dutch Research Council (NWO)","grant_id":"904-61-090","title":null},{"funder_name":"Chief Scientist Office","grant_id":"CZB/4/710","title":null},{"funder_name":"Medical Research Council","grant_id":"G0500539","title":null},{"funder_name":"Medical Research Council","grant_id":"G0600705","title":null},{"funder_name":"Medical Research Council","grant_id":"G0600717B","title":null},{"funder_name":"Medical Research Council","grant_id":"G19/35","title":null},{"funder_name":"Wellcome Trust","grant_id":"GR069224","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL105756","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"K08 AR055688","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC055022","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC075150","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-55015","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-85239","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK72488","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG013196","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG027058","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL087641","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01-DK072193","title":null},{"funder_name":"NIA NIH HHS","grant_id":"T32 AG000219","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"U01 HL080295","title":null},{"funder_name":"Wellcome Trust","grant_id":"075491/Z/04","title":null},{"funder_name":"ZonMw","grant_id":"31160008","title":null},{"funder_name":"NIA NIH HHS","grant_id":"AG-20098","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"DK56350","title":null},{"funder_name":"Medical Research Council","grant_id":"G0801056B","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"G20234","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL080295","title":null},{"funder_name":"AHRQ HHS","grant_id":"HS06516","title":null},{"funder_name":"NLM NIH HHS","grant_id":"LM010098","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_PC_U127561128","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC055015","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC055016","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC055020","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-85080","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"P20 RR020649","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG008724","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL075366","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL086694","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01HL59367","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"RC1 HL100245","title":null},{"funder_name":"FIC NIH HHS","grant_id":"TW05596","title":null},{"funder_name":"NHGRI NIH HHS","grant_id":"U01 HG004402","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"UL1RR025005","title":null},{"funder_name":"Wellcome Trust","grant_id":"090532","title":null},{"funder_name":"Wellcome Trust","grant_id":"092731","title":null},{"funder_name":"Wellcome Trust","grant_id":"098051","title":null},{"funder_name":"Dutch Research Council (NWO)","grant_id":"175.010.200","title":null},{"funder_name":"Dutch Research Council (NWO)","grant_id":"904-61-193","title":null},{"funder_name":"NIA NIH HHS","grant_id":"AG08861","title":null},{"funder_name":"Medical Research Council","grant_id":"G0701863","title":null},{"funder_name":"Medical Research Council","grant_id":"G0800582","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL087660","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"M01 RR 16500","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC-55222","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC055021","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-25195","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N02-HL-6-4278","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK056350","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG032098","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL059367","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL087679","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL087700","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH063706","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01-DK-8925601","title":null},{"funder_name":"Intramural NIH HHS","grant_id":"Z01 HG000024","title":null},{"funder_name":"NIA NIH HHS","grant_id":"AG10175","title":null},{"funder_name":"Medical Research Council","grant_id":"G0100222","title":null},{"funder_name":"Medical Research Council","grant_id":"G9521010","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL085144","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"K24 DK080140","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_UP_A100_1003","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC035129","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC045133","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC085086","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-55020","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-55021","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-75150","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK020572","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"P30 ES010126","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P60DK79637","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG018728","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG020098","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK062370","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK072193","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK075681","title":null},{"funder_name":"NLM NIH HHS","grant_id":"R01 LM010098","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01-DK062370","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01-HL-087700","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"RL1 MH083268","title":null},{"funder_name":"Wellcome Trust","grant_id":"081682","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"5R01MH63706:02","title":null},{"funder_name":"Dutch Research Council (NWO)","grant_id":"940-38-011","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"DK078150","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"ES10126","title":null},{"funder_name":"Medical Research Council","grant_id":"G0600705B","title":null},{"funder_name":"Medical Research Council","grant_id":"G0600717","title":null},{"funder_name":"Medical Research Council","grant_id":"G8802774","title":null},{"funder_name":"NHGRI NIH HHS","grant_id":"HHSN268200782096C","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL100245","title":null},{"funder_name":"NIA NIH HHS","grant_id":"N01 AG062101","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC025195","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC055019","title":null},{"funder_name":"NIA NIH HHS","grant_id":"N01-AG-1-2109","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-55019","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-85079","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-85083","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-85085","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG010175","title":null},{"funder_name":"FIC NIH HHS","grant_id":"R01 TW005596","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R56 AG023629","title":null},{"funder_name":"Wellcome Trust","grant_id":"098017","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"1RL1MH083268-01","title":null},{"funder_name":"Dutch Research Council (NWO)","grant_id":"480-05-003","title":null},{"funder_name":"NIA NIH HHS","grant_id":"AG-027058","title":null},{"funder_name":"NIA NIH HHS","grant_id":"AG028555","title":null},{"funder_name":"NIA NIH HHS","grant_id":"AG04563","title":null},{"funder_name":"Medical Research Council","grant_id":"G0902037","title":null},{"funder_name":"Medical Research Council","grant_id":"G1000143","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"M01 RR000425","title":null},{"funder_name":"NIA NIH HHS","grant_id":"N01 AG062103","title":null},{"funder_name":"NIA NIH HHS","grant_id":"N01 AG062106","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC015103","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC055222","title":null},{"funder_name":"NHGRI NIH HHS","grant_id":"N01 HG065403","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-55016","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-55022","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-85086","title":null},{"funder_name":"British Heart Foundation","grant_id":"PG/07/133/24260","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK078150","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK093757","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL088215","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"R24 HD050924","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R56 AG020098","title":null},{"funder_name":"NHGRI NIH HHS","grant_id":"T32 HG000040","title":null},{"funder_name":"Medical Research Council","grant_id":"U.1061.00.001 (79471)","title":null},{"funder_name":"Wellcome Trust","grant_id":"075491","title":null},{"funder_name":"Swiss National Science Foundation","grant_id":"122661","title":null},{"funder_name":"NIA NIH HHS","grant_id":"1R01AG032098-01A1","title":null},{"funder_name":"Medical Research Council","grant_id":"74882","title":null},{"funder_name":"Dutch Research Council (NWO)","grant_id":"985-10-002","title":null},{"funder_name":"Chief Scientist Office","grant_id":"CZB/4/672","title":null},{"funder_name":"Medical Research Council","grant_id":"G0401527","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"M01-RR00425","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_U127561128","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_U127592696","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC055018","title":null},{"funder_name":"NIA NIH HHS","grant_id":"N01-AG-1-2100","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-85084","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK072488","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG015928","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK054261","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL036310","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL080295","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL085144","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01-DK-075681","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R37 AG013196","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"U01 GM074518","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"U01 HL84756","title":null},{"funder_name":"Wellcome Trust","grant_id":"076467","title":null},{"funder_name":"Dutch Research Council (NWO)","grant_id":"481-08-013","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"5R01HL087679-02","title":null},{"funder_name":"NIA NIH HHS","grant_id":"AG-023629","title":null},{"funder_name":"NIA NIH HHS","grant_id":"AG08724","title":null},{"funder_name":"NIA NIH HHS","grant_id":"AG13196","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"DK063491","title":null},{"funder_name":"Medical Research Council","grant_id":"G1002084","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL075366","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL087652","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"M01 RR016500","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_PC_U127592696","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_U106179471","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC085079","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-55018","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-85081","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01-HC-85082","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N02 HL064278","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK063491","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P60 DK079637","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG023629","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG028555","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG18728","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK078616","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK54261","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL087652","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL087660","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL088119","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL105756","title":null},{"funder_name":"NIMHD NIH HHS","grant_id":"R01 MD009164","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01-HL-088215","title":null},{"funder_name":"British Heart Foundation","grant_id":"RG/07/008/23674","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"RR20649","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"U01 HL072515","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"U01 HL072515-06","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"U01 HL084756","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"U24 MH068457","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"U24 MH068457-06","title":null},{"funder_name":"NCATS NIH HHS","grant_id":"UL1 TR000130","title":null},{"funder_name":"National Institute for Health Research (NIHR)","grant_id":"","title":null}],"total_grants":200,"fwci":38.9602,"citation_percentile":0.99891767,"influential_citations":0,"citation_trend":[{"year":2012,"count":10},{"year":2013,"count":53},{"year":2014,"count":65},{"year":2015,"count":80},{"year":2016,"count":87},{"year":2017,"count":86},{"year":2018,"count":87},{"year":2019,"count":67},{"year":2020,"count":82},{"year":2021,"count":63},{"year":2022,"count":66},{"year":2023,"count":36},{"year":2024,"count":40},{"year":2025,"count":28},{"year":2026,"count":8}],"oa_status":"bronze","license":"https://www.springer.com/tdm","oa_locations":[{"url":"https://www.nature.com/articles/ng.2385.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/ng.2385.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/ng.2385","host_type":"publisher"},{"url":"https://doi.org/10.1038/ng.2385","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22885924","host_type":"repository"},{"url":"https://cris.maastrichtuniversity.nl/en/publications/b6b7887e-54dc-4c56-9048-bf40a1381591","host_type":"repository"},{"url":"https://research.rug.nl/en/publications/0acb07cf-2dd6-4c0e-bd25-19d3bd76a905","host_type":"repository"},{"url":"https://research-repository.uwa.edu.au/en/publications/78cbf84b-b1de-4963-b075-7c563ebe7c84","host_type":"repository"},{"url":"https://pure.eur.nl/en/publications/3c443567-8855-44e2-bbbf-1fadc970195a","host_type":"repository"},{"url":"http://hdl.handle.net/1887/97303","host_type":"repository"},{"url":"http://eprints.gla.ac.uk/68377/","host_type":"journal"},{"url":"http://discovery.ucl.ac.uk/1372913/","host_type":"repository"},{"url":"https://kclpure.kcl.ac.uk/portal/en/publications/bd13ecf4-3571-479f-bdd2-600e327f00e3","host_type":"repository"},{"url":"https://research.manchester.ac.uk/en/publications/a574e399-a96a-40d6-b3e3-65e2dea394e1","host_type":"repository"},{"url":"https://researchprofiles.ku.dk/da/publications/faf9fe59-8e92-42e6-8d69-ddba8337efd2","host_type":"repository"},{"url":"https://www.research.manchester.ac.uk/portal/en/publications/largescale-association-analyses-identify-new-loci-influencing-glycemic-traits-and-provide-insight-into-the-underlying-biological-pathways(a574e399-a96a-40d6-b3e3-65e2dea394e1).html","host_type":"repository"},{"url":"http://hdl.handle.net/1765/58771","host_type":""},{"url":"http://hdl.handle.net/11858/00-001M-0000-0029-5507-4","host_type":"repository"},{"url":"https://hdl.handle.net/11370/0acb07cf-2dd6-4c0e-bd25-19d3bd76a905","host_type":"repository"},{"url":"https://research-information.bris.ac.uk/en/publications/26f185d5-7299-49d9-b9e9-77468b900b51","host_type":"repository"},{"url":"https://hdl.handle.net/1887/97303","host_type":"repository"},{"url":"https://portal.findresearcher.sdu.dk/da/publications/f30593c4-7fbf-4be7-9ac4-e06da8a296b6","host_type":"repository"},{"url":"http://hdl.handle.net/10044/1/28913","host_type":"repository"},{"url":"https://pure.rug.nl/ws/files/2447001/Scott_2012_Nat_Genet.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3433394","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3433394?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Genetic Associations and Epidemiology","Genetic Mapping and Diversity in Plants and Animals","Lipid metabolism and biosynthesis"],"mesh_terms":["Adult","Animals","Blood Glucose","Fasting","Female","Gene Frequency","Humans","Insulin","Male","Osmolar Concentration","Quantitative Trait Loci","Mice","Metabolic Networks and Pathways","Genome-Wide Association Study"],"keywords":["Biology","Genome-wide association study","Glycemic","Genetic association","Insulin resistance","Genetics","Type 2 diabetes","Quantitative trait locus","Diabetes mellitus","Gene","Computational biology","Genotype","Single-nucleotide polymorphism","Endocrinology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"refsnp"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T04:07:12.065216Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}