{"doi":"10.1038/ng.235","title":"Structure and function of a transcriptional network activated by the MAPK Hog1","abstract":"Cells regulate gene expression using a complex network of signaling pathways, transcription factors and promoters. To gain insight into the structure and function of these networks, we analyzed gene expression in single- and multiple-mutant strains to build a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast. Our model reveals that the Hog1 and general stress (Msn2/4) pathways interact, at both the signaling and promoter level, to integrate information and create a context-dependent response. This study lays out a path to identifying and characterizing the role of signal integration and processing in other gene regulatory networks.","journal":"Nature Genetics","year":2008,"id":3898,"datarank":0.818937827121624,"base_score":5.459585514144159,"endowment":5.459585514144159,"self_citation_contribution":0.818937827121624,"citation_network_contribution":0.0,"self_endowment_contribution":0.818937827121624,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":234,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0493,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2008-10-19","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":39694,"name":"Tommy Kaplan","orcid":"0000-0002-1892-5461","position":1,"is_corresponding":false},{"id":39695,"name":"Ying Liu","orcid":"0000-0003-3672-9621","position":2,"is_corresponding":false},{"id":7418,"name":"Naomi Habib","orcid":"0000-0002-6049-2487","position":3,"is_corresponding":false},{"id":29633,"name":"Prisca Liberali","orcid":"0000-0003-0695-6081","position":4,"is_corresponding":false},{"id":11210,"name":"Nir Friedman","orcid":"0000-0002-9678-3550","position":5,"is_corresponding":false},{"id":22080,"name":"Erin K. O’Shea","orcid":"0000-0002-2649-1018","position":7,"is_corresponding":false},{"id":39693,"name":"Andrew P. Capaldi","orcid":"0000-0002-7902-2477","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}