{"doi":"10.1038/ncomms8465","title":"Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization","abstract":null,"journal":"Nature Communications","year":2015,"id":640739,"datarank":0.7565137675378871,"base_score":5.043425116919247,"endowment":5.043425116919247,"self_citation_contribution":0.7565137675378871,"citation_network_contribution":0.0,"self_endowment_contribution":0.7565137675378871,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":154,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1665403,"name":"Shaoqin Han","orcid":null,"position":1,"is_corresponding":false},{"id":1032473,"name":"Bowen Xing","orcid":"0000-0002-1244-8545","position":2,"is_corresponding":false},{"id":292041,"name":"Jianyun Huang","orcid":"0000-0002-2147-8826","position":3,"is_corresponding":false},{"id":1083593,"name":"Bingqian Liu","orcid":"0000-0001-5710-7210","position":4,"is_corresponding":false},{"id":1665407,"name":"Francois Bordeleau","orcid":null,"position":5,"is_corresponding":false},{"id":1665408,"name":"Cynthia A. Reinhart-King","orcid":null,"position":6,"is_corresponding":false},{"id":477920,"name":"J. Jillian Zhang","orcid":null,"position":7,"is_corresponding":false},{"id":293615,"name":"Xin-Yun Huang","orcid":null,"position":8,"is_corresponding":false},{"id":1665400,"name":"Fang-Ke Huang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization","abstract":"One of the key steps during tumour metastasis is tumour cell migration and invasion, which require actin cytoskeletal reorganization. Among the critical actin cytoskeletal protrusion structures are the filopodia, which act like cell sensory organs to communicate with the extracellular microenvironment and participate in fundamental cell functions such as cell adhesion, spreading and migration in the three-dimensional environment. Fascin is the main actin-bundling protein in filopodia. Using high-throughput screening, here we identify and characterize small molecules that inhibit the actin-bundling activity of fascin. Focusing on one such inhibitor, we demonstrate that it specifically blocks filopodial formation, tumour cell migration and invasion in vitro, and metastasis in vivo. Hence, target-specific anti-fascin agents have a therapeutic potential for cancer treatment. As metastasis requires cellular machinery of migration and invasion, interfering with these functions is a promising anticancer strategy. Here the authors show that a structurally novel fascin inhibitor blocks filopodia formation, migration and invasion, and effectively inhibits metastasis in mice.","is_dataset_classified":null,"base_score":5.043425116919247,"endowment":5.043425116919247,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26081695","pmcid":null,"openalex_id":"https://openalex.org/W1204907234","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"U54CA143876","title":null},{"funder_name":"National Institutes of Health","grant_id":"3U54CA143876-05S1","title":"Diversity Supplement Magnolia Ariza-Nieto"}],"total_grants":2,"fwci":4.6575,"citation_percentile":0.95406682,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2016,"count":7},{"year":2017,"count":13},{"year":2018,"count":10},{"year":2019,"count":13},{"year":2020,"count":13},{"year":2021,"count":28},{"year":2022,"count":27},{"year":2023,"count":10},{"year":2024,"count":14},{"year":2025,"count":13},{"year":2026,"count":5}],"oa_status":"gold","license":"Springer Nature TDM","oa_locations":[{"url":"https://www.nature.com/articles/ncomms8465.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/ncomms8465.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/ncomms8465","host_type":"publisher"},{"url":"https://doi.org/10.1038/ncomms8465","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26081695","host_type":"repository"},{"url":"https://dx.doi.org/10.1038/ncomms8465","host_type":""}],"fields_of_study":["Cellular Mechanics and Interactions","Cell Adhesion Molecules Research","Skin and Cellular Biology Research","0301 basic medicine","0303 health sciences","03 medical and health sciences","Actins","Animals","Carrier Proteins","Cell Movement","Drug Evaluation, Preclinical","Female","High-Throughput Screening Assays","Humans","Indazoles","Mice, Inbred BALB C","Mice, Inbred NOD","Mice, Nude","Mice, SCID","Microfilament Proteins","Neoplasms","Pseudopodia"],"mesh_terms":["Actins","Animals","Carrier Proteins","Cell Movement","Drug Evaluation, Preclinical","Female","Humans","Indazoles","Mice, Inbred BALB C","Mice, Nude","Microfilament Proteins","Neoplasms","Pseudopodia","Mice, SCID","Mice, Inbred NOD","High-Throughput Screening Assays"],"keywords":["Fascin","Filopodia","Cell biology","Cell migration","Cytoskeleton","Biology","Lamellipodium","Actin","Metastasis","Actin cytoskeleton","Pseudopodia","Cell adhesion","Cell","Cancer research","Chemistry","Cancer","Biochemistry","Mice, Inbred BALB C","Indazoles","Microfilament Proteins","Drug Evaluation, Preclinical","Mice, Nude","Mice, SCID","Actins","High-Throughput Screening Assays","Cell Movement","Mice, Inbred NOD","Neoplasms","Animals","Humans","Female","Carrier Proteins"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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