{"doi":"10.1038/ncomms6671","title":"miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13","abstract":null,"journal":"Nature Communications","year":2014,"id":612203,"datarank":7.823610486041882,"base_score":5.214935757608986,"endowment":5.214935757608986,"self_citation_contribution":0.782240363641348,"citation_network_contribution":7.041370122400534,"self_endowment_contribution":0.782240363641348,"citer_contribution":7.041370122400534,"corpus_percentile":null,"corpus_rank":null,"citation_count":183,"citer_count":167,"citers_with_citation_signal":157,"citers_with_endowment":157,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":593323,"name":"Li Wang","orcid":"0000-0002-5570-1336","position":1,"is_corresponding":false},{"id":602832,"name":"Cristian Rodriguez-Aguayo","orcid":null,"position":2,"is_corresponding":false},{"id":344376,"name":"Yuan Yuan","orcid":"0000-0003-4223-326X","position":3,"is_corresponding":false},{"id":353096,"name":"Bisrat G. 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Kian Ang","orcid":null,"position":16,"is_corresponding":false},{"id":163613,"name":"Junjie Chen","orcid":"0000-0003-3056-9962","position":17,"is_corresponding":false},{"id":829400,"name":"Li Ma","orcid":"0000-0003-3873-5080","position":18,"is_corresponding":false},{"id":1576169,"name":"Peijing Zhang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13","abstract":"Tumour cells associated with therapy resistance (radioresistance and drug resistance) are likely to give rise to local recurrence and distant metastatic relapse. Recent studies revealed microRNA (miRNA)-mediated regulation of metastasis and epithelial-mesenchymal transition; however, whether specific miRNAs regulate tumour radioresistance and can be exploited as radiosensitizing agents remains unclear. Here we find that miR-205 promotes radiosensitivity and is downregulated in radioresistant subpopulations of breast cancer cells, and that loss of miR-205 is highly associated with poor distant relapse-free survival in breast cancer patients. Notably, therapeutic delivery of miR-205 mimics via nanoliposomes can sensitize the tumour to radiation in a xenograft model. Mechanistically, radiation suppresses miR-205 expression through ataxia telangiectasia mutated (ATM) and zinc finger E-box binding homeobox 1 (ZEB1). Moreover, miR-205 inhibits DNA damage repair by targeting ZEB1 and the ubiquitin-conjugating enzyme Ubc13. These findings identify miR-205 as a radiosensitizing miRNA and reveal a new therapeutic strategy for radioresistant tumours.","is_dataset_classified":null,"base_score":5.214935757608986,"endowment":5.214935757608986,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25476932","pmcid":"PMC4377070","openalex_id":"https://openalex.org/W2059550947","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R43 GM100777","title":null},{"funder_name":"NCI NIH HHS","grant_id":"U54CA151668","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R00 CA138572","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA166051","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01CA181029","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R44 GM086937","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P50 CA100632","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA164346","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA016672","title":null},{"funder_name":"NCI NIH HHS","grant_id":"CA100632","title":null},{"funder_name":"National Institutes of Health","grant_id":"3P50CA100632-06S1","title":"University of Texas M.D. Anderson Cancer Center SPORE - 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