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Although 3' UTR shortening in proliferating cells is conserved between human and mouse, orthologous genes do not exhibit similar expression of alternative 3' UTR isoforms. We generally find that 3' UTR shortening is not accompanied by a corresponding change in mRNA and protein levels. This suggests that although 3' UTR shortening may lead to changes in the RNA-binding protein interactome, it has limited effects on protein output.","is_dataset_classified":null,"base_score":5.356586274672012,"endowment":5.356586274672012,"datacite_reuse_total":16,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25413384","pmcid":null,"openalex_id":"https://openalex.org/W2073461718","authors":[],"funders":[{"funder_name":"Swiss National Science Foundation","grant_id":"143977","title":"The molecular biology of RNA 3' end processing"},{"funder_name":"Swiss National Science Foundation","grant_id":"146463","title":"Regulation of Cell Surface Signaling by Coronin Proteins"},{"funder_name":"Swiss National Science Foundation","grant_id":"124819","title":"T Cell Biology in Health and Disease"},{"funder_name":"Fundação para a Ciência e a Tecnologia, I.P.","grant_id":"PTDC/CCI-INF/6762/2020","title":"MS3: New foundations for micro-services 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