{"doi":"10.1038/ncomms3136","title":"SNAP-25 regulates spine formation through postsynaptic binding to p140Cap","abstract":null,"journal":"Nature Communications","year":2013,"id":648546,"datarank":2.4147065891364283,"base_score":4.276666119016055,"endowment":4.276666119016055,"self_citation_contribution":0.6414999178524083,"citation_network_contribution":1.77320667128402,"self_endowment_contribution":0.6414999178524083,"citer_contribution":1.77320667128402,"corpus_percentile":null,"corpus_rank":null,"citation_count":71,"citer_count":56,"citers_with_citation_signal":51,"citers_with_endowment":51,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1690217,"name":"Daniele Repetto","orcid":null,"position":1,"is_corresponding":false},{"id":228562,"name":"Raffaella Morini","orcid":"0000-0002-4403-6932","position":2,"is_corresponding":false},{"id":1690224,"name":"Chiara Elia","orcid":null,"position":3,"is_corresponding":false},{"id":631952,"name":"Fabrizio Gardoni","orcid":"0000-0003-4598-5563","position":4,"is_corresponding":false},{"id":1546102,"name":"Monica Di Luca","orcid":null,"position":5,"is_corresponding":false},{"id":1281842,"name":"Emilia Turco","orcid":null,"position":6,"is_corresponding":false},{"id":1480943,"name":"Paola Defilippi","orcid":"0000-0001-6427-4906","position":7,"is_corresponding":false},{"id":228574,"name":"Michela Matteoli","orcid":"0000-0002-3569-7843","position":8,"is_corresponding":false},{"id":1690213,"name":"Romana Tomasoni","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"SNAP-25 regulates spine formation through postsynaptic binding to p140Cap","abstract":"Synaptosomal-associated protein of 25 kDa (SNAP-25) is a member of the Soluble N-ethylmaleimide-sensitive-factor attachment protein receptors (SNARE) protein family, required for exocytosis of synaptic vesicles and regulation of diverse ion channels. Here, we show that acute reduction of SNAP-25 expression leads to an immature phenotype of dendritic spines that are, consistently, less functional. Conversely, over-expression of SNAP-25 results in an increase in the density of mature, Postsynaptic Density protein 95 (PSD-95)-positive spines. The regulation of spine morphogenesis by SNAP-25 depends on the protein's ability to bind both the plasma membrane and the adaptor protein p140Cap, a key protein regulating actin cytoskeleton and spine formation. We propose that SNAP-25 allows the organization of the molecular apparatus needed for spine formation by recruiting and stabilizing p140Cap.","is_dataset_classified":null,"base_score":4.276666119016055,"endowment":4.276666119016055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23868368","pmcid":null,"openalex_id":"https://openalex.org/W1986504110","authors":[],"funders":[{"funder_name":"European Commission","grant_id":"241498","title":"European Consortium on Synaptic Protein Networks in Neurological and Psychiatric Diseases"}],"total_grants":1,"fwci":2.5874,"citation_percentile":0.88387854,"influential_citations":0,"citation_trend":[{"year":2014,"count":5},{"year":2015,"count":7},{"year":2016,"count":5},{"year":2017,"count":5},{"year":2018,"count":9},{"year":2019,"count":7},{"year":2020,"count":7},{"year":2021,"count":1},{"year":2022,"count":6},{"year":2023,"count":8},{"year":2024,"count":5},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"bronze","license":"Springer Nature TDM","oa_locations":[{"url":"https://www.nature.com/articles/ncomms3136.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/ncomms3136.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/ncomms3136","host_type":"publisher"},{"url":"https://doi.org/10.1038/ncomms3136","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23868368","host_type":"repository"},{"url":"http://hdl.handle.net/2434/231882","host_type":"repository"},{"url":"http://dx.doi.org/10.1038/ncomms3136","host_type":""},{"url":"https://dx.doi.org/10.1038/ncomms3136","host_type":""},{"url":"https://hdl.handle.net/20.500.14243/257514","host_type":""},{"url":"https://hdl.handle.net/2434/231882","host_type":""}],"fields_of_study":["Cellular transport and secretion","Neuroscience and Neuropharmacology Research","Retinal Development and Disorders","0301 basic medicine","0303 health sciences","03 medical and health sciences","Actin Cytoskeleton","Adaptor Proteins, Vesicular Transport","Animals","Dendritic Spines","Disks Large Homolog 4 Protein","Embryo, Mammalian","Gene Expression Regulation, Developmental","HeLa Cells","Hippocampus","Humans","Intracellular Signaling Peptides and Proteins","Membrane Proteins","Primary Cell Culture","Protein Binding","Protein Stability","Rats","Signal Transduction","Synaptosomal-Associated Protein 25"],"mesh_terms":["Disks Large Homolog 4 Protein","Animals","Embryo, Mammalian","HeLa Cells","Hippocampus","Humans","Membrane Proteins","Actin Cytoskeleton","Protein Binding","Signal Transduction","Gene Expression Regulation, Developmental","Adaptor Proteins, Vesicular Transport","Intracellular Signaling Peptides and Proteins","Dendritic Spines","Synaptosomal-Associated Protein 25","Rats","Protein Stability","Primary Cell Culture","Hela Cells"],"keywords":["Dendritic spine","Postsynaptic density","Cell biology","Postsynaptic potential","Exocytosis","Signal transducing adaptor protein","Snap","SPINE (molecular biology)","Biology","Actin cytoskeleton","Chemistry","Receptor","Cytoskeleton","Signal transduction","Secretion","Cell","Biochemistry","Neuroscience","Synaptosomal-Associated Protein 25","Protein Stability","Dendritic Spines","Primary Cell Culture","Intracellular Signaling Peptides and Proteins","Gene Expression Regulation, Developmental","Membrane Proteins","gene expression regulation, developmental; actin cytoskeleton; adaptor proteins, vesicular transport; animals; dendritic spines; embryo, mammalian; hela cells; hippocampus; humans; intracellular signaling peptides and proteins; membrane proteins; primary cell culture; protein binding; protein stability; rats; signal transduction; synaptosomal-associated protein 25","Embryo, Mammalian","Hippocampus","Rats","Adaptor Proteins, Vesicular Transport","Animals","Humans","Disks Large Homolog 4 Protein","HeLa Cells","Protein Binding"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T02:43:51.791049Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}