{"doi":"10.1038/ncomms15616","title":"INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers","abstract":"ATP-dependent chromatin remodellers modulate nucleosome dynamics by mobilizing or disassembling nucleosomes, as well as altering nucleosome composition. These chromatin remodellers generally function by translocating along nucleosomal DNA at the H3-H4 interface of nucleosomes. Here we show that, unlike other remodellers, INO80 translocates along DNA at the H2A-H2B interface of nucleosomes and persistently displaces DNA from the surface of H2A-H2B. DNA translocation and DNA torsional strain created near the entry site of nucleosomes by INO80 promotes both the mobilization of nucleosomes and the selective exchange of H2A.Z-H2B dimers out of nucleosomes and replacement by H2A-H2B dimers without any additional histone chaperones. We find that INO80 translocates and mobilizes H2A.Z-containing nucleosomes more efficiently than those containing H2A, partially accounting for the preference of INO80 to replace H2A.Z with H2A. Our data suggest that INO80 has a mechanism for dimer exchange that is distinct from other chromatin remodellers including its paralogue SWR1.","journal":"Nature Communications","year":2017,"id":4362,"datarank":4.604483145321235,"base_score":5.0369526024136295,"endowment":5.0369526024136295,"self_citation_contribution":0.7555428903620446,"citation_network_contribution":3.848940254959191,"self_endowment_contribution":0.7555428903620446,"citer_contribution":3.848940254959191,"corpus_percentile":null,"corpus_rank":null,"citation_count":153,"citer_count":142,"citers_with_citation_signal":115,"citers_with_endowment":115,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.056,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2017-06-12","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":44958,"name":"Maheshi I. Udugama","orcid":null,"position":1,"is_corresponding":false},{"id":44959,"name":"Jongseong Kim","orcid":"0000-0001-9595-2765","position":2,"is_corresponding":false},{"id":44960,"name":"Arjan Hada","orcid":null,"position":3,"is_corresponding":false},{"id":44961,"name":"Saurabh K. Bhardwaj","orcid":"0000-0003-3648-2964","position":4,"is_corresponding":false},{"id":44962,"name":"Solomon G. Hailu","orcid":null,"position":5,"is_corresponding":false},{"id":44963,"name":"Tae-Hee Lee","orcid":"0000-0003-2034-6394","position":6,"is_corresponding":false},{"id":44964,"name":"Blaine Bartholomew","orcid":"0000-0003-4014-9750","position":7,"is_corresponding":false},{"id":44965,"name":"Maheshi Udugama","orcid":"0000-0003-0412-4142","position":8,"is_corresponding":false},{"id":44957,"name":"Sandipan Brahma","orcid":"0000-0001-7511-5409","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}