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Network analysis prioritizes <jats:italic>MAP1LC3B</jats:italic> (<jats:italic>LC3</jats:italic>) and <jats:italic>BECN1</jats:italic> as most impactful. Knockdown of <jats:italic>LC3</jats:italic> and <jats:italic>BECN1</jats:italic> expression confers sensitivity to cells undergoing autophagic stress independent of platinum resistance status. The results support the use of pathway network tools to evaluate how the copy-number landscape of a tumour may guide therapy.</jats:p>","journal":"Nature Communications","year":2017,"id":599795,"datarank":0.5641800173540344,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":0.0,"self_endowment_contribution":0.5641800173540344,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1537299,"name":"Chandni B. 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Here we build haploinsufficiency network analyses to identify which SCNA patterns are most disruptive in OV. Of all KEGG pathways (<jats:italic>N</jats:italic>=187), autophagy is the most significantly disrupted by coincident gene deletions. Compared with 20 other cancer types, OV is most severely disrupted in autophagy and in compensatory proteostasis pathways. Network analysis prioritizes <jats:italic>MAP1LC3B</jats:italic> (<jats:italic>LC3</jats:italic>) and <jats:italic>BECN1</jats:italic> as most impactful. Knockdown of <jats:italic>LC3</jats:italic> and <jats:italic>BECN1</jats:italic> expression confers sensitivity to cells undergoing autophagic stress independent of platinum resistance status. 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