{"doi":"10.1038/ncomms12460","title":"Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis","abstract":"Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment of the utility of SNP data for predicting anti-TNF treatment efficacy in RA patients was performed in the context of a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled the comparative evaluation of predictions developed by 73 research groups using the most comprehensive available data and covering a wide range of state-of-the-art modelling methodologies. Despite a significant genetic heritability estimate of treatment non-response trait (h(2)=0.18, P value=0.02), no significant genetic contribution to prediction accuracy is observed. Results formally confirm the expectations of the rheumatology community that SNP information does not significantly improve predictive performance relative to standard clinical traits, thereby justifying a refocusing of future efforts on collection of other data.","journal":"Nature Communications","year":2016,"id":6100,"datarank":0.637274286307404,"base_score":4.248495242049359,"endowment":4.248495242049359,"self_citation_contribution":0.637274286307404,"citation_network_contribution":0.0,"self_endowment_contribution":0.637274286307404,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":69,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.1048,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2016-08-23","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":27471,"name":"Fan Zhu","orcid":"0009-0007-2339-9084","position":1,"is_corresponding":false},{"id":27472,"name":"Javier García-García","orcid":null,"position":2,"is_corresponding":false},{"id":27473,"name":"Eli Stahl","orcid":null,"position":3,"is_corresponding":false},{"id":27474,"name":"Abhishek Pratap","orcid":"0000-0002-5289-6932","position":4,"is_corresponding":false},{"id":27475,"name":"Gaurav Pandey","orcid":"0000-0003-1939-679X","position":5,"is_corresponding":false},{"id":27476,"name":"Dimitrios Pappas","orcid":null,"position":6,"is_corresponding":false},{"id":27477,"name":"Daniel Aguilar","orcid":"0000-0001-7520-4508","position":7,"is_corresponding":false},{"id":27478,"name":"Bernat Anton","orcid":null,"position":8,"is_corresponding":false},{"id":27479,"name":"Jaume Bonet","orcid":"0000-0001-5210-4387","position":9,"is_corresponding":false},{"id":27480,"name":"Ridvan Eksi","orcid":"0000-0003-2757-0057","position":10,"is_corresponding":false},{"id":27481,"name":"Oriol Fornés","orcid":"0000-0002-5969-3054","position":11,"is_corresponding":false},{"id":12606,"name":"Benjamin Haibe‐Kains","orcid":"0000-0002-7684-0079","position":12,"is_corresponding":false},{"id":27482,"name":"Hongdong Li","orcid":"0000-0003-2803-3560","position":13,"is_corresponding":false},{"id":27483,"name":"Manuel Alejandro Marín","orcid":null,"position":14,"is_corresponding":false},{"id":27484,"name":"Bharat Panwar","orcid":"0000-0002-4227-9615","position":15,"is_corresponding":false},{"id":27485,"name":"Joan Planas-Iglesias","orcid":"0000-0002-6279-2483","position":16,"is_corresponding":false},{"id":27486,"name":"Daniel Poglayen","orcid":null,"position":17,"is_corresponding":false},{"id":27487,"name":"Jing Cui","orcid":"0000-0001-8657-1741","position":18,"is_corresponding":false},{"id":12315,"name":"Andre O. Falcao","orcid":null,"position":19,"is_corresponding":false},{"id":27488,"name":"Christine Suver","orcid":"0000-0002-2986-385X","position":20,"is_corresponding":false},{"id":27489,"name":"Bruce Hoff","orcid":"0000-0002-4629-2091","position":21,"is_corresponding":false},{"id":27490,"name":"Venkat S. K. Balagurusamy","orcid":null,"position":22,"is_corresponding":false},{"id":27491,"name":"Donna Dillenberger","orcid":null,"position":23,"is_corresponding":false},{"id":12556,"name":"Elias Chaibub Neto","orcid":"0000-0002-9575-861X","position":24,"is_corresponding":false},{"id":12557,"name":"Thea Norman","orcid":"0000-0003-2707-4387","position":25,"is_corresponding":false},{"id":12244,"name":"Tero Aittokallio","orcid":"0000-0002-0886-9769","position":26,"is_corresponding":false},{"id":27492,"name":"Muhammad Ammad-ud-din","orcid":"0009-0001-4464-5295","position":27,"is_corresponding":false},{"id":27553,"name":"Chloé‐Agathe Azencott","orcid":"0000-0003-1003-301X","position":28,"is_corresponding":false},{"id":27494,"name":"Víctor Bellón","orcid":null,"position":29,"is_corresponding":false},{"id":27495,"name":"Valentina Boeva","orcid":"0000-0002-4382-7185","position":30,"is_corresponding":false},{"id":27496,"name":"Kerstin Bunte","orcid":"0000-0002-2930-6172","position":31,"is_corresponding":false},{"id":27497,"name":"Himanshu Chheda","orcid":null,"position":32,"is_corresponding":false},{"id":27498,"name":"Lu Cheng","orcid":"0000-0002-6391-2360","position":33,"is_corresponding":false},{"id":27499,"name":"Jukka Corander","orcid":"0000-0002-7752-1942","position":34,"is_corresponding":false},{"id":74,"name":"Michel J. Dumontier","orcid":"0000-0003-4727-9435","position":35,"is_corresponding":false},{"id":12334,"name":"Anna Goldenberg","orcid":"0000-0002-2416-833X","position":36,"is_corresponding":false},{"id":27500,"name":"Peddinti Gopalacharyulu","orcid":"0000-0002-8767-968X","position":37,"is_corresponding":false},{"id":27501,"name":"Mohsen Hajiloo","orcid":null,"position":38,"is_corresponding":false},{"id":12351,"name":"Daniel Hidru","orcid":null,"position":39,"is_corresponding":false},{"id":6334,"name":"Alok Jaiswal","orcid":"0000-0002-1910-4681","position":40,"is_corresponding":false},{"id":12374,"name":"Samuel Kaski","orcid":"0000-0003-1925-9154","position":41,"is_corresponding":false},{"id":27502,"name":"Beyrem Khalfaoui","orcid":null,"position":42,"is_corresponding":false},{"id":12377,"name":"Suleiman Ali Khan","orcid":null,"position":43,"is_corresponding":false},{"id":27503,"name":"Eric R. Kramer","orcid":null,"position":44,"is_corresponding":false},{"id":12421,"name":"Pekka Marttinen","orcid":"0000-0001-7078-7927","position":45,"is_corresponding":false},{"id":27504,"name":"Aziz M. Mezlini","orcid":"0000-0002-8533-6843","position":46,"is_corresponding":false},{"id":27505,"name":"Bhuvan Molparia","orcid":null,"position":47,"is_corresponding":false},{"id":27506,"name":"Matti Pirinen","orcid":"0000-0002-1664-1350","position":48,"is_corresponding":false},{"id":27507,"name":"Janna Saarela","orcid":"0000-0002-0853-6219","position":49,"is_corresponding":false},{"id":27508,"name":"Matthias Samwald","orcid":"0000-0002-4855-2571","position":50,"is_corresponding":false},{"id":27509,"name":"Véronique Stoven","orcid":"0000-0003-0828-0759","position":51,"is_corresponding":false},{"id":27510,"name":"Hao Tang","orcid":"0000-0003-1709-5889","position":52,"is_corresponding":false},{"id":12645,"name":"Ziaurrehman Tanoli","orcid":"0000-0003-2435-9862","position":53,"is_corresponding":false},{"id":27511,"name":"Ali Torkamani","orcid":"0000-0003-0232-8053","position":54,"is_corresponding":false},{"id":27512,"name":"Jean-Phillipe Vert","orcid":null,"position":55,"is_corresponding":false},{"id":27513,"name":"Bo Wang","orcid":"0000-0002-9620-3413","position":56,"is_corresponding":false},{"id":2738,"name":"Tao Wang","orcid":"0000-0002-1218-4017","position":57,"is_corresponding":false},{"id":12526,"name":"Krister Wennerberg","orcid":"0000-0002-1352-4220","position":58,"is_corresponding":false},{"id":27514,"name":"Nathan E. Wineinger","orcid":"0000-0003-4517-228X","position":59,"is_corresponding":false},{"id":27515,"name":"Guanghua Xiao","orcid":"0000-0001-9387-9883","position":60,"is_corresponding":false},{"id":20648,"name":"Yang Xie","orcid":"0000-0003-4293-0014","position":61,"is_corresponding":false},{"id":27516,"name":"Rae Yeung","orcid":null,"position":62,"is_corresponding":false},{"id":14650,"name":"Xiaowei Zhan","orcid":"0000-0002-6249-7193","position":63,"is_corresponding":false},{"id":27517,"name":"Cheng Zhao","orcid":"0000-0002-1991-7295","position":64,"is_corresponding":false},{"id":27518,"name":"Members of the Rheumatoid Arthritis Challenge Consortium","orcid":null,"position":65,"is_corresponding":false},{"id":12275,"name":"Manuel Calaza","orcid":"0000-0003-3082-525X","position":66,"is_corresponding":false},{"id":12310,"name":"Haitham Elmarakeby","orcid":"0000-0002-4315-4347","position":67,"is_corresponding":false},{"id":12347,"name":"Lenwood S. Heath","orcid":"0000-0003-1608-431X","position":68,"is_corresponding":false},{"id":27519,"name":"Quan Long","orcid":"0000-0003-3795-1873","position":69,"is_corresponding":false},{"id":27520,"name":"Jonathan D. Moore","orcid":"0000-0002-5486-0407","position":70,"is_corresponding":false},{"id":27521,"name":"Stephen Obol Opiyo","orcid":null,"position":71,"is_corresponding":false},{"id":27522,"name":"Richard S. Savage","orcid":"0000-0001-6025-1571","position":72,"is_corresponding":false},{"id":22914,"name":"Jun Zhu","orcid":"0000-0002-3231-7235","position":73,"is_corresponding":false},{"id":27523,"name":"Jeff Greenberg","orcid":"0000-0002-2206-0771","position":74,"is_corresponding":false},{"id":27524,"name":"Joel Kremer","orcid":null,"position":75,"is_corresponding":false},{"id":27525,"name":"Kaleb Michaud","orcid":"0000-0002-5350-3934","position":76,"is_corresponding":false},{"id":27526,"name":"Anne Barton","orcid":"0000-0003-3316-2527","position":77,"is_corresponding":false},{"id":27527,"name":"Marieke Coenen","orcid":null,"position":78,"is_corresponding":false},{"id":27528,"name":"Xavier Mariette","orcid":"0000-0002-4244-5417","position":79,"is_corresponding":false},{"id":27531,"name":"Michael Weinblatt","orcid":null,"position":82,"is_corresponding":false},{"id":27532,"name":"Niek de Vries","orcid":"0000-0002-6257-8604","position":83,"is_corresponding":false},{"id":27536,"name":"Fina Kurreeman","orcid":null,"position":87,"is_corresponding":false},{"id":27537,"name":"Cornelia F. Allaart","orcid":"0000-0003-4815-2110","position":88,"is_corresponding":false},{"id":27540,"name":"Larry Moreland","orcid":null,"position":91,"is_corresponding":false},{"id":27541,"name":"Lars Klareskog","orcid":null,"position":92,"is_corresponding":false},{"id":27542,"name":"Saedis Saevarsdottir","orcid":null,"position":93,"is_corresponding":false},{"id":27543,"name":"Leonid Padyukov","orcid":"0000-0003-2950-5670","position":94,"is_corresponding":false},{"id":27544,"name":"Peter K. Gregersen","orcid":"0000-0003-1613-1518","position":95,"is_corresponding":false},{"id":12324,"name":"Stephen Friend","orcid":"0000-0002-0830-7600","position":96,"is_corresponding":false},{"id":27545,"name":"Robert M. Plenge","orcid":"0000-0002-3705-5924","position":97,"is_corresponding":false},{"id":12562,"name":"Gustavo Stolovitzky","orcid":"0000-0002-9618-2819","position":98,"is_corresponding":false},{"id":12444,"name":"Catharina Olsen","orcid":"0000-0002-6193-2296","position":99,"is_corresponding":false},{"id":4926,"name":"Yuanfang Guan","orcid":"0000-0001-8275-2852","position":100,"is_corresponding":false},{"id":27546,"name":"Lara M. Mangravite","orcid":"0000-0001-7841-3612","position":101,"is_corresponding":false},{"id":27547,"name":"Javier Garcı́a-Garcı́a","orcid":"0000-0001-9539-2606","position":102,"is_corresponding":false},{"id":3815,"name":"Eli A. Stahl","orcid":"0000-0002-1192-0561","position":103,"is_corresponding":false},{"id":27548,"name":"Dimitrios A. Pappas","orcid":"0000-0001-8338-027X","position":104,"is_corresponding":false},{"id":12605,"name":"Emre Güney","orcid":"0000-0002-3466-6535","position":105,"is_corresponding":false},{"id":27550,"name":"Manuel Alejandro Marín-López","orcid":"0000-0003-0833-3574","position":106,"is_corresponding":false},{"id":12594,"name":"André O. Falcão","orcid":"0000-0002-3588-8746","position":107,"is_corresponding":false},{"id":12611,"name":"Suleiman A. Khan","orcid":"0000-0002-0823-4042","position":108,"is_corresponding":false},{"id":27554,"name":"Rae S. M. Yeung","orcid":"0000-0003-2361-725X","position":109,"is_corresponding":false},{"id":27556,"name":"Stephen O. Opiyo","orcid":"0000-0001-7933-9004","position":110,"is_corresponding":false},{"id":27558,"name":"Marieke J. H. Coenen","orcid":"0000-0001-8796-2031","position":111,"is_corresponding":false},{"id":27559,"name":"Corinne Miceli‐Richard","orcid":"0000-0002-3009-3637","position":112,"is_corresponding":false},{"id":27560,"name":"Nancy A. Shadick","orcid":"0000-0003-3953-845X","position":113,"is_corresponding":false},{"id":27561,"name":"Michael E. Weinblatt","orcid":"0000-0001-5215-5512","position":114,"is_corresponding":false},{"id":27562,"name":"Daniëlle M. Gerlag","orcid":null,"position":115,"is_corresponding":false},{"id":18392,"name":"T. Huizinga","orcid":"0000-0001-7033-7520","position":116,"is_corresponding":false},{"id":2822,"name":"Lindsey A. Criswell","orcid":"0000-0002-0761-7543","position":117,"is_corresponding":false},{"id":27563,"name":"Larry W. Moreland","orcid":"0000-0003-4483-0359","position":118,"is_corresponding":false},{"id":27564,"name":"Saedís Saevarsdóttir","orcid":"0000-0001-9392-6184","position":119,"is_corresponding":false},{"id":27470,"name":"Solveig K. Sieberts","orcid":"0000-0003-1033-0954","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}