{"doi":"10.1038/ncomms11161","title":"Cdk1 activity acts as a quantitative platform for coordinating cell cycle progression with periodic transcription","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Cell proliferation is regulated by cyclin-dependent kinases (Cdks) and requires the periodic expression of particular gene clusters in different cell cycle phases. However, the interplay between the networks that generate these transcriptional oscillations and the core cell cycle machinery remains largely unexplored. In this work, we use a synthetic regulable Cdk1 module to demonstrate that periodic expression is governed by quantitative changes in Cdk1 activity, with different clusters directly responding to specific activity levels. We further establish that cell cycle events neither participate in nor interfere with the Cdk1-driven transcriptional program, provided that cells are exposed to the appropriate Cdk1 activities. These findings contrast with current models that propose self-sustained and Cdk1-independent transcriptional oscillations. Our work therefore supports a model in which Cdk1 activity serves as a quantitative platform for coordinating cell cycle transitions with the expression of critical genes to bring about proper cell cycle progression.</jats:p>","journal":"Nature Communications","year":2016,"id":42517,"datarank":1.4827587627196026,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.9494565534961905,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.9494565534961905,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":28,"citers_with_citation_signal":26,"citers_with_endowment":26,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":203404,"name":"Feriel Baïdi","orcid":null,"position":1,"is_corresponding":false},{"id":203405,"name":"Damien Coudreuse","orcid":null,"position":2,"is_corresponding":false},{"id":203406,"name":"Zsolt Szilagyi","orcid":null,"position":3,"is_corresponding":false},{"id":203403,"name":"Gabor Banyai","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27045731","pmcid":"PMC4822045","openalex_id":"https://openalex.org/W2315285126","authors":[],"funders":[{"funder_name":"European Research Council","grant_id":"310849","title":"Architecture and logic of the eukaryotic cell cycle"}],"total_grants":1,"fwci":3.4823,"citation_percentile":0.92641528,"influential_citations":1,"citation_trend":[{"year":2016,"count":3},{"year":2017,"count":7},{"year":2018,"count":6},{"year":2019,"count":4},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":5},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.nature.com/articles/ncomms11161.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/ncomms11161.pdf","host_type":"GOLD"},{"url":"https://www.nature.com/articles/ncomms11161.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/ncomms11161","host_type":"publisher"},{"url":"https://doi.org/10.1038/ncomms11161","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27045731","host_type":"repository"},{"url":"https://univ-rennes.hal.science/hal-01299978","host_type":"repository"},{"url":"https://doaj.org/article/14fd02f2836143969ca0e6808a740f35","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4822045","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4822045","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4822045?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1038/ncomms11161","host_type":""},{"url":"https://dx.doi.org/10.1038/ncomms11161","host_type":""},{"url":"https://univ-rennes.hal.science/hal-01299978v1/document","host_type":""},{"url":"https://univ-rennes.hal.science/hal-01299978v1","host_type":""}],"fields_of_study":["Genomics and Chromatin Dynamics","DNA Repair Mechanisms","Cancer-related Molecular Pathways","Biology","Medicine","0301 basic medicine","0303 health sciences","03 medical and health sciences","CDC2 Protein Kinase","Cell Cycle","Gene Expression Profiling","Gene Expression Regulation, Fungal","Multigene Family","Periodicity","Purines","Schizosaccharomyces","Schizosaccharomyces pombe Proteins","Signal Transduction","Transcription, Genetic"],"mesh_terms":["Cell Cycle","Multigene Family","Periodicity","Purines","Schizosaccharomyces","Transcription, Genetic","Signal Transduction","Gene Expression Regulation, Fungal","CDC2 Protein Kinase","Gene Expression Profiling","Schizosaccharomyces pombe Proteins"],"keywords":["Cyclin-dependent kinase 1","Cyclin-dependent kinase","Cell cycle","Cell biology","Biology","Transcription factor","Cyclin","Transcription (linguistics)","Cell","Gene","Genetics","Periodicity","Transcription, Genetic","Science","Gene Expression Profiling","Q","Article","Purines","Gene Expression Regulation, Fungal","Multigene Family","CDC2 Protein Kinase","Schizosaccharomyces","[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]","Schizosaccharomyces pombe Proteins","Signal Transduction"],"sdg_mappings":[{"sdg_number":9,"sdg_label":"9. 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