{"doi":"10.1038/nchembio.1184","title":"Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling","abstract":null,"journal":"Nature Chemical Biology","year":2013,"id":47508,"datarank":5.976108238759479,"base_score":5.075173815233827,"endowment":5.075173815233827,"self_citation_contribution":0.7612760722850741,"citation_network_contribution":5.214832166474404,"self_endowment_contribution":0.7612760722850741,"citer_contribution":5.214832166474404,"corpus_percentile":null,"corpus_rank":null,"citation_count":159,"citer_count":144,"citers_with_citation_signal":138,"citers_with_endowment":138,"datacite_reuse_total":4,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":219844,"name":"Jessica Rios-Esteves","orcid":null,"position":1,"is_corresponding":false},{"id":219845,"name":"Ouathek Ouerfelli","orcid":null,"position":2,"is_corresponding":false},{"id":219846,"name":"J Fraser Glickman","orcid":null,"position":3,"is_corresponding":false},{"id":219847,"name":"Marilyn D Resh","orcid":null,"position":4,"is_corresponding":false},{"id":219843,"name":"Elissaveta Petrova","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling","abstract":"Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical for Shh signaling, as a new target for Shh pathway inhibition. A target-oriented high-throughput screen was used to identify small-molecule inhibitors of Hhat. In cells, these Hhat inhibitors specifically block Shh palmitoylation and inhibit autocrine and paracrine Shh signaling.","is_dataset_classified":null,"base_score":5.075173815233827,"endowment":5.075173815233827,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23416332","pmcid":"PMC3604071","openalex_id":"https://openalex.org/W2007333388","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"F31 GM100691","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R21 CA158474","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA008748-43","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA008748","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM057966","title":null},{"funder_name":"NCI NIH HHS","grant_id":"CA158474","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM57966","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01GM057966-12","title":"Palmitoylation of Hedgehog Proteins"},{"funder_name":"National Institutes of Health","grant_id":"2P30CA008748-43","title":"MOUSE GENETICS"},{"funder_name":"National Institutes of Health","grant_id":"5R21CA158474-02","title":"Hedgehog Palmitoylation as a Novel Target for Inhibiting Pancreatic Cancer"}],"total_grants":10,"fwci":7.6697,"citation_percentile":0.98090924,"influential_citations":4,"citation_trend":[{"year":2013,"count":7},{"year":2014,"count":11},{"year":2015,"count":25},{"year":2016,"count":9},{"year":2017,"count":16},{"year":2018,"count":13},{"year":2019,"count":13},{"year":2020,"count":5},{"year":2021,"count":19},{"year":2022,"count":12},{"year":2023,"count":10},{"year":2024,"count":12},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604071","host_type":"GREEN"},{"url":"http://www.nature.com/articles/nchembio.1184.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nchembio.1184","host_type":"publisher"},{"url":"https://doi.org/10.1038/nchembio.1184","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23416332","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.790.5359","host_type":""},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3604071","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3604071","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3604071?pdf=render","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/pmc3604071?pdf=render","host_type":""},{"url":"http://dx.doi.org/10.1038/nchembio.1184","host_type":""},{"url":"https://dx.doi.org/10.1038/nchembio.1184","host_type":""}],"fields_of_study":["Hedgehog Signaling Pathway Studies","Cleft Lip and Palate Research","Epigenetics and DNA Methylation","Medicine","Biology","Chemistry","0301 basic medicine","0303 health sciences","03 medical and health sciences","Acyltransferases","Animals","COS Cells","Chlorocebus aethiops","Enzyme Inhibitors","Gene Expression","Genes, Reporter","Hedgehog Proteins","High-Throughput Screening Assays","Humans","Lipoylation","Luciferases","Mice","Porcupines","Signal Transduction","Small Molecule Libraries","Structure-Activity Relationship","Transfection"],"mesh_terms":["Acyltransferases","Animals","Chlorocebus aethiops","Enzyme Inhibitors","Humans","Luciferases","Structure-Activity Relationship","Transfection","Signal Transduction","Gene Expression","Genes, Reporter","COS Cells","Porcupines","Mice","Hedgehog Proteins","Small Molecule Libraries","Lipoylation","High-Throughput Screening Assays"],"keywords":["Sonic hedgehog","Smoothened","Hedgehog signaling pathway","Palmitoylation","Hedgehog","Autocrine signalling","Cell biology","Paracrine signalling","Acyltransferase","Biology","Chemistry","GLI2","Signal transduction","Biochemistry","Enzyme","Receptor","Lipoylation","Gene Expression","Porcupines","Transfection","Article","High-Throughput Screening Assays","Small Molecule Libraries","Mice","Structure-Activity Relationship","Genes, Reporter","COS Cells","Chlorocebus aethiops","Animals","Humans","Hedgehog Proteins","Enzyme Inhibitors","Luciferases","Acyltransferases"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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