{"doi":"10.1038/nchem.1062","title":"Contemporary strategies for peptide macrocyclization","abstract":null,"journal":"Nature Chemistry","year":2011,"id":614471,"datarank":1.0470113910842647,"base_score":6.980075940561763,"endowment":6.980075940561763,"self_citation_contribution":1.0470113910842647,"citation_network_contribution":0.0,"self_endowment_contribution":1.0470113910842647,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1074,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1239192,"name":"Andrei K. Yudin","orcid":"0000-0003-3170-9103","position":1,"is_corresponding":false},{"id":51563,"name":"Christopher J. White","orcid":"0000-0001-8618-7539","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Contemporary strategies for peptide macrocyclization","abstract":"Peptide macrocycles have found applications that range from drug discovery to nanomaterials. These ring-shaped molecules have shown remarkable capacity for functional fine-tuning. Such capacity is enabled by the possibility of adjusting the peptide conformation using the techniques of chemical synthesis. Cyclic peptides have been difficult, and often impossible, to prepare using traditional synthetic methods. For macrocyclization to occur, the activated peptide must adopt an entropically disfavoured pre-cyclization conformation before forming the desired product. Here, we review recent solutions to some of the major challenges in this important area of contemporary synthesis.","is_dataset_classified":null,"base_score":6.980075940561763,"endowment":6.980075940561763,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21697871","pmcid":null,"openalex_id":"https://openalex.org/W2041593863","authors":[],"funders":[{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"}],"total_grants":1,"fwci":21.7801,"citation_percentile":0.99749599,"influential_citations":0,"citation_trend":[{"year":2012,"count":40},{"year":2013,"count":54},{"year":2014,"count":80},{"year":2015,"count":69},{"year":2016,"count":75},{"year":2017,"count":88},{"year":2018,"count":104},{"year":2019,"count":79},{"year":2020,"count":64},{"year":2021,"count":84},{"year":2022,"count":77},{"year":2023,"count":72},{"year":2024,"count":72},{"year":2025,"count":79},{"year":2026,"count":32}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://www.nature.com/articles/nchem.1062.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nchem.1062","host_type":"publisher"},{"url":"https://doi.org/10.1038/nchem.1062","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21697871","host_type":"repository"},{"url":"https://dx.doi.org/10.1038/nchem.1062","host_type":""}],"fields_of_study":["Chemical Synthesis and Analysis","Click Chemistry and Applications","Biochemical and Structural Characterization","01 natural sciences","0104 chemical sciences","Molecular Conformation","Molecular Structure","Peptides","Peptides, Cyclic"],"mesh_terms":["Molecular Conformation","Peptides","Peptides, Cyclic","Molecular Structure"],"keywords":["Chemistry","Peptide","Cyclic peptide","Combinatorial chemistry","Drug discovery","Ring (chemistry)","Molecule","Nanotechnology","Small molecule","Nanomaterials","Biochemistry","Organic chemistry","Molecular Structure","Molecular Conformation","Peptides","Peptides, Cyclic"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T13:38:39.457394Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}