{"doi":"10.1038/ncb835","title":"Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins","abstract":null,"journal":"Nature Cell Biology","year":2002,"id":623670,"datarank":10.169150529531306,"base_score":5.153291594497779,"endowment":5.153291594497779,"self_citation_contribution":0.772993739174667,"citation_network_contribution":9.396156790356638,"self_endowment_contribution":0.772993739174667,"citer_contribution":9.396156790356638,"corpus_percentile":null,"corpus_rank":null,"citation_count":172,"citer_count":163,"citers_with_citation_signal":145,"citers_with_endowment":145,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1611878,"name":"Mohammad Irani-Tehrani","orcid":null,"position":1,"is_corresponding":false},{"id":324391,"name":"William B. Kiosses","orcid":"0000-0003-1832-9050","position":2,"is_corresponding":false},{"id":1611880,"name":"Miguel A. Del Pozo","orcid":null,"position":3,"is_corresponding":false},{"id":270346,"name":"Martin A. Schwartz","orcid":"0000-0002-2071-1243","position":4,"is_corresponding":false},{"id":1611876,"name":"Nahum Meller","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins","abstract":"The Rho family GTPases Rac, Rho and Cdc42 are critical in regulating the actin-based cytoskeleton, cell migration, growth, survival and gene expression. These GTPases are activated by guanine nucleotide-exchange factors (GEFs). A biochemical search for Cdc42 activators led to the cloning of zizimin1, a new protein whose overexpression induces Cdc42 activation. Sequence comparison combined with mutational analysis identified a new domain, which we named CZH2, that mediates direct interaction with Cdc42. CZH2-containing proteins constitute a new superfamily that includes the so-called 'CDM' proteins that bind to and activate Rac. Together, the results suggest that CZH2 is a new GEF domain for the Rho family of proteins.","is_dataset_classified":null,"base_score":5.153291594497779,"endowment":5.153291594497779,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12172552","pmcid":null,"openalex_id":"https://openalex.org/W1980943495","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM41721","title":null}],"total_grants":1,"fwci":4.1535,"citation_percentile":0.94252874,"influential_citations":0,"citation_trend":[{"year":2012,"count":13},{"year":2013,"count":7},{"year":2014,"count":7},{"year":2015,"count":4},{"year":2016,"count":2},{"year":2017,"count":6},{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":10},{"year":2021,"count":4},{"year":2022,"count":5},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2026,"count":3}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://www.nature.com/articles/ncb835.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/ncb835","host_type":"publisher"},{"url":"https://doi.org/10.1038/ncb835","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12172552","host_type":"repository"}],"fields_of_study":["Cellular Mechanics and Interactions","Microtubule and mitosis dynamics","Protein Kinase Regulation and GTPase Signaling"],"mesh_terms":["Amino Acid Sequence","Animals","Binding Sites","Cloning, Molecular","Enzyme Activation","Humans","Molecular Sequence Data","RNA, Messenger","Tissue Distribution","3T3 Cells","Sequence Homology, Amino Acid","Protein Structure, Tertiary","Guanine Nucleotide Exchange Factors","rho GTP-Binding Proteins","cdc42 GTP-Binding Protein","Mice"],"keywords":["CDC42","Guanine nucleotide exchange factor","GTPase","Cell biology","Actin cytoskeleton","DOCK","Biology","Effector","Activator (genetics)","Rac GTP-Binding Proteins","RAC1","Cytoskeleton","Chemistry","Gene","Genetics","Cell","Signal transduction"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T00:50:07.319208Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}