{"doi":"10.1038/ncb3563","title":"AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia","abstract":"Leukaemogenesis requires enhanced self-renewal, which is induced by oncogenes. The underlying molecular mechanisms remain incompletely understood. Here, we identified C/D box snoRNAs and rRNA 2'-O-methylation as critical determinants of leukaemic stem cell activity. Leukaemogenesis by AML1-ETO required expression of the groucho-related amino-terminal enhancer of split (AES). AES functioned by inducing snoRNA/RNP formation via interaction with the RNA helicase DDX21. Similarly, global loss of C/D box snoRNAs with concomitant loss of rRNA 2'-O-methylation resulted in decreased leukaemia self-renewal potential. Genomic deletion of either C/D box snoRNA SNORD14D or SNORD35A suppressed clonogenic potential of leukaemia cells in vitro and delayed leukaemogenesis in vivo. We further showed that AML1-ETO9a, MYC and MLL-AF9 all enhanced snoRNA formation. Expression levels of C/D box snoRNAs in AML patients correlated closely with in vivo frequency of leukaemic stem cells. Collectively, these findings indicate that induction of C/D box snoRNA/RNP function constitutes an important pathway in leukaemogenesis.","journal":"Nature Cell Biology","year":2017,"id":2951,"datarank":0.7622106547476696,"base_score":5.081404364984463,"endowment":5.081404364984463,"self_citation_contribution":0.7622106547476696,"citation_network_contribution":0.0,"self_endowment_contribution":0.7622106547476696,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":160,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0461,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2017-06-26","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":27253,"name":"Yi Liu","orcid":"0000-0002-0821-7322","position":1,"is_corresponding":false},{"id":32719,"name":"Christian Rohde","orcid":"0000-0001-6778-5971","position":2,"is_corresponding":false},{"id":32720,"name":"Cornelius Pauli","orcid":"0000-0001-8506-1571","position":3,"is_corresponding":false},{"id":32721,"name":"Dennis Gerloff","orcid":"0000-0002-3815-0157","position":4,"is_corresponding":false},{"id":32722,"name":"Marcel Köhn","orcid":"0000-0003-3292-8447","position":5,"is_corresponding":false},{"id":32723,"name":"Danny Misiak","orcid":"0000-0001-5931-8425","position":6,"is_corresponding":false},{"id":32724,"name":"Nicole Bäumer","orcid":"0000-0002-7530-467X","position":7,"is_corresponding":false},{"id":32725,"name":"Chunhong Cui","orcid":"0000-0002-7705-204X","position":8,"is_corresponding":false},{"id":32726,"name":"Stefanie Göllner","orcid":"0000-0002-2934-1920","position":9,"is_corresponding":false},{"id":32727,"name":"Thomas Oellerich","orcid":"0000-0001-6570-6125","position":10,"is_corresponding":false},{"id":32728,"name":"Hubert Serve","orcid":"0000-0001-8472-5516","position":11,"is_corresponding":false},{"id":32729,"name":"Maria-Paz Garcia-Cuellar","orcid":null,"position":12,"is_corresponding":false},{"id":32730,"name":"Robert K. 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