{"doi":"10.1038/ncb2451","title":"Homeostatic control of recombination is implemented progressively in mouse meiosis","abstract":null,"journal":"Nature Cell Biology","year":2012,"id":642827,"datarank":0.8386480470766287,"base_score":5.5909869805108565,"endowment":5.5909869805108565,"self_citation_contribution":0.8386480470766287,"citation_network_contribution":0.0,"self_endowment_contribution":0.8386480470766287,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":267,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":204419,"name":"Liisa Kauppi","orcid":null,"position":1,"is_corresponding":false},{"id":568036,"name":"Julian Lange","orcid":null,"position":2,"is_corresponding":false},{"id":203586,"name":"Ignasi Roig","orcid":"0000-0003-0313-3581","position":3,"is_corresponding":false},{"id":360764,"name":"Raymond Wang","orcid":"0000-0001-6494-7613","position":4,"is_corresponding":false},{"id":254578,"name":"Scott Keeney","orcid":"0000-0002-1283-6417","position":5,"is_corresponding":false},{"id":465827,"name":"Maria Jasin","orcid":"0000-0002-7976-2379","position":6,"is_corresponding":false},{"id":675191,"name":"Francesca Cole","orcid":"0000-0001-6391-2363","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Homeostatic control of recombination is implemented progressively in mouse meiosis","abstract":"Humans suffer from high rates of fetal aneuploidy, often arising from the absence of meiotic crossover recombination between homologous chromosomes. Meiotic recombination is initiated by double-strand breaks (DSBs) generated by the SPO11 transesterase. In yeast and worms, at least one buffering mechanism, crossover homeostasis, maintains crossover numbers despite variation in DSB numbers. We show here that mammals exhibit progressive homeostatic control of recombination. In wild-type mouse spermatocytes, focus numbers for early recombination proteins (RAD51, DMC1) were highly variable from cell to cell, whereas foci of the crossover marker MLH1 showed little variability. Furthermore, mice with greater or fewer copies of the Spo11 gene--with correspondingly greater or fewer numbers of early recombination foci--exhibited relatively invariant crossover numbers. Homeostatic control is enforced during at least two stages, after the formation of early recombination intermediates and later while these intermediates mature towards crossovers. Thus, variability within the mammalian meiotic program is robustly managed by homeostatic mechanisms to control crossover formation, probably to suppress aneuploidy. Meiotic recombination exemplifies how order can be progressively implemented in a self-organizing system despite natural cell-to-cell disparities in the underlying biochemical processes.","is_dataset_classified":null,"base_score":5.5909869805108565,"endowment":5.5909869805108565,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22388890","pmcid":"PMC3319518","openalex_id":"https://openalex.org/W1972809713","authors":[],"funders":[{"funder_name":"NICHD NIH HHS","grant_id":"F32HD51392","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"R01 HD040916","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"F32 HD051392","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"HD040916","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01HD040916-09","title":"Role of Spo11 and recombination in mouse meiosis"},{"funder_name":"National Institutes of Health","grant_id":"5F32HD051392-03","title":"Apoptosis in recombination-deficient meiocytes"},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":8,"fwci":7.6127,"citation_percentile":0.98278948,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":21},{"year":2014,"count":18},{"year":2015,"count":16},{"year":2016,"count":15},{"year":2017,"count":21},{"year":2018,"count":21},{"year":2019,"count":27},{"year":2020,"count":17},{"year":2021,"count":18},{"year":2022,"count":19},{"year":2023,"count":18},{"year":2024,"count":18},{"year":2025,"count":16},{"year":2026,"count":15}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://www.nature.com/articles/ncb2451.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/ncb2451","host_type":"publisher"},{"url":"https://doi.org/10.1038/ncb2451","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22388890","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.803.5982","host_type":""},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3319518","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3319518","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3319518?pdf=render","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/pmc3319518?pdf=render","host_type":""},{"url":"http://dx.doi.org/10.1038/ncb2451","host_type":""},{"url":"https://dx.doi.org/10.1038/ncb2451","host_type":""}],"fields_of_study":["DNA Repair Mechanisms","CRISPR and Genetic Engineering","Photosynthetic Processes and Mechanisms","0303 health sciences","03 medical and health sciences","Animals","Cell Cycle Proteins","Endodeoxyribonucleases","Homeostasis","Male","Meiosis","Mice","Mice, Inbred Strains","Nuclear Proteins","Phosphate-Binding Proteins","Rad51 Recombinase","Recombination, Genetic","Spermatocytes","Meiotic Recombination Protein SPO11"],"mesh_terms":["Meiotic Recombination Protein SPO11","Animals","Endodeoxyribonucleases","Homeostasis","Male","Meiosis","Mice, Inbred Strains","Nuclear Proteins","Recombination, Genetic","Spermatocytes","Cell Cycle Proteins","Phosphate-Binding Proteins","Rad51 Recombinase","Mice"],"keywords":["Meiosis","Homologous recombination","Biology","Genetic recombination","Recombination","RAD51","Genetics","Mitotic crossover","Cell biology","Homologous chromosome","Gene","Male","Recombination, Genetic","Endodeoxyribonucleases","Nuclear Proteins","Cell Cycle Proteins","Mice, Inbred Strains","Phosphate-Binding Proteins","Article","Mice","Spermatocytes","Animals","Homeostasis","Rad51 Recombinase","Meiotic Recombination Protein SPO11"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T04:20:28.167516Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}