{"doi":"10.1038/ncb1265","title":"Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies","abstract":null,"journal":"Nature Cell Biology","year":2005,"id":605088,"datarank":0.9687507425017186,"base_score":6.45833828334479,"endowment":6.45833828334479,"self_citation_contribution":0.9687507425017186,"citation_network_contribution":0.0,"self_endowment_contribution":0.9687507425017186,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":637,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":243030,"name":"Helen M. Blau","orcid":"0000-0001-6503-5480","position":1,"is_corresponding":false},{"id":432555,"name":"George L. Sen","orcid":"0000-0003-1279-8550","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies","abstract":"RNA interference (RNAi) is an important means of eliminating mRNAs, but the intracellular location of RNA-induced silencing complex (RISC) remains unknown. We show here that Argonaute 2, a key component of RISC, is not randomly distributed but concentrates in mRNA decay centres that are known as cytoplasmic bodies. The localization of Argonaute 2 in decay centres is not altered by the presence or absence of small interfering RNAs or their targeted mRNAs. However, RNA is required for the integrity of cytoplasmic bodies because RNase eliminates Argonaute 2 localization. In addition, Argonaute 1, another Argonaute family member, is concentrated in cytoplasmic bodies. These results provide new insight into the mechanism of RNAi function.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15908945","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"AG20961","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL65572","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"HD18179","title":null},{"funder_name":"NIA NIH HHS","grant_id":"AG09521","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01HD018179-03","title":"DEVELOPMENTAL REGULATION OF HUMAN MUSCLE PROTEINS"}],"total_grants":5,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"Springer TDM","oa_locations":[{"url":"http://www.nature.com/articles/ncb1265","host_type":"publisher"},{"url":"http://www.nature.com/articles/ncb1265.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1038/ncb1265","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/15908945","host_type":""},{"url":"https://dx.doi.org/10.1038/ncb1265","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Cytoplasm","Animals","Humans","Mice","Macromolecular Substances","RNA-Induced Silencing Complex","Organic Cation Transport Proteins","RNA-Binding Proteins","Peptide Initiation Factors","Eukaryotic Initiation Factor-2","RNA, Small Interfering","RNA, Messenger","Autoantigens","RNA Interference","Argonaute Proteins","Organic Cation Transporter 3"],"keywords":["Cytoplasm","Organic Cation Transport Proteins","Macromolecular Substances","Eukaryotic Initiation Factor-2","RNA-Binding Proteins","Organic Cation Transporter 3","Autoantigens","Mice","Peptide Initiation Factors","Argonaute Proteins","Animals","Humans","RNA-Induced Silencing Complex","RNA Interference","RNA, Messenger","RNA, Small Interfering"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T01:37:47.403557Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}