{"doi":"10.1038/ncb0910-836","title":"Selective autophagy: ubiquitin-mediated recognition and beyond","abstract":null,"journal":"Nature Cell Biology","year":2010,"id":594633,"datarank":0.9689856681566303,"base_score":6.459904454377535,"endowment":6.459904454377535,"self_citation_contribution":0.9689856681566303,"citation_network_contribution":0.0,"self_endowment_contribution":0.9689856681566303,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":638,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":145729,"name":"Matthias Peter","orcid":null,"position":1,"is_corresponding":false},{"id":90539,"name":"Kay Hofmann","orcid":"0000-0002-2289-9083","position":2,"is_corresponding":false},{"id":474725,"name":"Claudine Kraft","orcid":"0000-0002-3324-4701","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Selective autophagy: ubiquitin-mediated recognition and beyond","abstract":"Eukaryotic cells use autophagy and the ubiquitin-proteasome system as their major protein degradation pathways. Whereas the ubiquitin-proteasome system is involved in the rapid degradation of proteins, autophagy pathways can selectively remove protein aggregates and damaged or excess organelles. Proteasome-mediated degradation requires previous ubiquitylation of the cargo, which is then recognized by ubiquitin receptors directing it to 26S proteasomes. Although autophagy has long been viewed as a random cytoplasmic degradation system, the involvement of ubiquitin as a specificity factor for selective autophagy is rapidly emerging. Recent evidence also suggests active crosstalk between proteasome-mediated degradation and selective autophagy. Here, we discuss the molecular mechanisms that link autophagy and the proteasome system, as well as the emerging roles of ubiquitin and ubiquitin-binding proteins in selective autophagy. On the basis of the evolutionary history of autophagic ubiquitin receptors, we propose a common origin for metazoan ubiquitin-dependent autophagy and the cytoplasm-to-vacuole targeting pathway of yeast.","is_dataset_classified":null,"base_score":6.459904454377535,"endowment":6.459904454377535,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20811356","pmcid":null,"openalex_id":"https://openalex.org/W2155612332","authors":[],"funders":[],"total_grants":0,"fwci":29.0621,"citation_percentile":0.99838042,"influential_citations":0,"citation_trend":[{"year":2012,"count":54},{"year":2013,"count":58},{"year":2014,"count":59},{"year":2015,"count":52},{"year":2016,"count":56},{"year":2017,"count":53},{"year":2018,"count":53},{"year":2019,"count":27},{"year":2020,"count":38},{"year":2021,"count":28},{"year":2022,"count":41},{"year":2023,"count":20},{"year":2024,"count":27},{"year":2025,"count":19},{"year":2026,"count":4}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://www.nature.com/articles/ncb0910-836.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/ncb0910-836","host_type":"publisher"},{"url":"https://doi.org/10.1038/ncb0910-836","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20811356","host_type":"repository"}],"fields_of_study":["Autophagy in Disease and Therapy","Ubiquitin and proteasome pathways","Toxoplasma gondii Research Studies"],"mesh_terms":["Aging","Animals","Autophagy","Carrier Proteins","Inclusion Bodies","Eukaryotic Cells","Humans","Models, Biological","Phylogeny","Proteins","Protein Folding","Evolution, Molecular","Ubiquitin","Ubiquitin-Protein Ligases","Proteasome Endopeptidase Complex","Protein Interaction Domains and Motifs","Ubiquitination","Ubiquitinated Proteins"],"keywords":["Autophagy","Ubiquitin","Cell biology","Proteasome","Crosstalk","Protein degradation","Vacuole","Biology","Ubiquitin-conjugating enzyme","Cytoplasm","Ubiquitin ligase","Lysosome","Ubiquitins","Ubiquitin-Protein Ligases","Organelle","Biochemistry","Apoptosis","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T15:06:45.088977Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}