{"doi":"10.1038/nbt.1667","title":"Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells","abstract":null,"journal":"Nature Biotechnology","year":2010,"id":623325,"datarank":1.0620039749883887,"base_score":7.080026499922591,"endowment":7.080026499922591,"self_citation_contribution":1.0620039749883887,"citation_network_contribution":0.0,"self_endowment_contribution":1.0620039749883887,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1187,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":984612,"name":"Susanna Liu","orcid":"0000-0002-7747-5691","position":1,"is_corresponding":false},{"id":1610851,"name":"Maria Eugenia Figueroa","orcid":null,"position":2,"is_corresponding":false},{"id":742674,"name":"Warakorn Kulalert","orcid":null,"position":3,"is_corresponding":false},{"id":1610852,"name":"Sarah Eminli","orcid":null,"position":4,"is_corresponding":false},{"id":1610853,"name":"Kah Yong Tan","orcid":null,"position":5,"is_corresponding":false},{"id":56471,"name":"Effie Apostolou","orcid":"0000-0002-8111-0863","position":6,"is_corresponding":false},{"id":455292,"name":"Matthias Stadtfeld","orcid":"0000-0002-5852-9906","position":7,"is_corresponding":false},{"id":1610854,"name":"Yushan Li","orcid":null,"position":8,"is_corresponding":false},{"id":481672,"name":"Toshi Shioda","orcid":"0000-0002-9434-7835","position":9,"is_corresponding":false},{"id":725328,"name":"Sridaran Natesan","orcid":null,"position":10,"is_corresponding":false},{"id":1610855,"name":"Amy J Wagers","orcid":null,"position":11,"is_corresponding":false},{"id":237422,"name":"Ari Melnick","orcid":"0000-0002-8074-2287","position":12,"is_corresponding":false},{"id":109233,"name":"Todd Evans","orcid":"0000-0002-7148-9849","position":13,"is_corresponding":false},{"id":56485,"name":"Konrad Hochedlinger","orcid":"0000-0001-5811-5386","position":14,"is_corresponding":false},{"id":1610850,"name":"Jose M Polo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells","abstract":"Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here we show that iPSCs obtained from mouse fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns. Moreover, we demonstrate that cellular origin influences the in vitro differentiation potentials of iPSCs into embryoid bodies and different hematopoietic cell types. Notably, continuous passaging of iPSCs largely attenuates these differences. Our results suggest that early-passage iPSCs retain a transient epigenetic memory of their somatic cells of origin, which manifests as differential gene expression and altered differentiation capacity. These observations may influence ongoing attempts to use iPSCs for disease modeling and could also be exploited in potential therapeutic applications to enhance differentiation into desired cell lineages.","is_dataset_classified":null,"base_score":7.080026499922591,"endowment":7.080026499922591,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20644536","pmcid":"PMC3148605","openalex_id":"https://openalex.org/W2126580353","authors":[],"funders":[{"funder_name":"NIH HHS","grant_id":"DP2 OD004345-01","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK036836","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL056182","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL056182","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R37 HL056182","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"R01 HD058013","title":null},{"funder_name":"NIH HHS","grant_id":"DP2 OD004345","title":null},{"funder_name":"National Institutes of Health","grant_id":"1DP2OD004345-01","title":"Aging and Rejuvenation of the hematopoietic stem cell niche"},{"funder_name":"National Institutes of Health","grant_id":"2P30DK036836-36","title":"Diabetes Research Center"},{"funder_name":"National Institutes of Health","grant_id":"2R01HL056182-11","title":"Regulation of Embryonic Erythropoiesis by BMP Signaling"},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":11,"fwci":62.991,"citation_percentile":0.99973282,"influential_citations":0,"citation_trend":[{"year":2012,"count":149},{"year":2013,"count":129},{"year":2014,"count":112},{"year":2015,"count":79},{"year":2016,"count":90},{"year":2017,"count":72},{"year":2018,"count":47},{"year":2019,"count":49},{"year":2020,"count":55},{"year":2021,"count":53},{"year":2022,"count":27},{"year":2023,"count":31},{"year":2024,"count":29},{"year":2025,"count":22},{"year":2026,"count":14}],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:12724030","host_type":"repository"},{"url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:12724030","host_type":"repository"},{"url":"https://www.nature.com/articles/nbt.1667.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/nbt.1667","host_type":"publisher"},{"url":"https://doi.org/10.1038/nbt.1667","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20644536","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3148605","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc3148605?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.1038/nbt.1667","host_type":""},{"url":"https://doi.org/https://doi.org/10.1038/nbt.1667","host_type":""}],"fields_of_study":["Pluripotent Stem Cells Research","CRISPR and Genetic Engineering","Renal and related cancers","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","B-Lymphocytes","Cell Differentiation","Cells, Cultured","Fibroblasts","Hematopoietic Stem Cells","Stem Cells","Transcription, Genetic","Muscle, Skeletal","Cell Lineage","Gene Expression Profiling","Mice","Induced Pluripotent Stem Cells","Epigenomics","Embryoid Bodies"],"keywords":["Induced pluripotent stem cell","Embryoid body","Somatic cell","Biology","Epigenetics","Cell type","Cell biology","Cellular differentiation","Ectopic expression","Embryonic stem cell","Haematopoiesis","Stem cell","Cell","Genetics","Gene","Epigenomics","570","B-Lymphocytes","Transcription, Genetic","Gene Expression Profiling","Stem Cells","Induced Pluripotent Stem Cells","610","Cell Differentiation","Fibroblasts","Hematopoietic Stem Cells","Mice","Animals","Cell Lineage","Muscle, Skeletal","Cells, Cultured","Embryoid Bodies"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T23:17:36.455345Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}