{"doi":"10.1038/nature25462","title":"Cryo-EM shows how dynactin recruits two dyneins for faster movement","abstract":null,"journal":"Nature","year":2018,"id":680566,"datarank":0.8694086626148059,"base_score":5.796057750765372,"endowment":5.796057750765372,"self_citation_contribution":0.8694086626148059,"citation_network_contribution":0.0,"self_endowment_contribution":0.8694086626148059,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":328,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":203747,"name":"Clinton K. Lau","orcid":null,"position":1,"is_corresponding":false},{"id":203748,"name":"Mohamed M. Elshenawy","orcid":null,"position":2,"is_corresponding":false},{"id":203749,"name":"Edgar Morales-Rios","orcid":null,"position":3,"is_corresponding":false},{"id":203750,"name":"Carina Motz","orcid":null,"position":4,"is_corresponding":false},{"id":203751,"name":"Ahmet Yildiz","orcid":null,"position":5,"is_corresponding":false},{"id":201954,"name":"Andrew P. Carter","orcid":null,"position":6,"is_corresponding":false},{"id":201888,"name":"Linas Urnavicius","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cryo-EM shows how dynactin recruits two dyneins for faster movement","abstract":"Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to distinct cargoes. Here we use electron microscopy and single-molecule studies to show that adaptors can recruit a second dynein to dynactin. Whereas BICD2 is biased towards recruiting a single dynein, the adaptors BICDR1 and HOOK3 predominantly recruit two dyneins. We find that the shift towards a double dynein complex increases both the force and speed of the microtubule motor. Our 3.5 Å resolution cryo-electron microscopy reconstruction of a dynein tail-dynactin-BICDR1 complex reveals how dynactin can act as a scaffold to coordinate two dyneins side-by-side. Our work provides a structural basis for understanding how diverse adaptors recruit different numbers of dyneins and regulate the motile properties of the dynein-dynactin transport machine.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29420470","pmcid":"PMC5988349","openalex_id":null,"authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"210711/Z/18/Z","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM094522","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_UP_A025_1011","title":"The structure and mechanism of Dynein"},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM118773","title":null},{"funder_name":"Wellcome Trust","grant_id":"100387","title":"Transport of cargo by cytoplasmic dynein."},{"funder_name":"National Science Foundation","grant_id":"1055017","title":"CAREER: Single Molecule Studies to Dissect the Mechanochemistry of Cytoplasmic Dynein"}],"total_grants":6,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://www.nature.com/articles/nature25462.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nature25462","host_type":"publisher"},{"url":"http://www.nature.com/doifinder/10.1038/nature25462","host_type":"publisher"},{"url":"https://europepmc.org/articles/PMC5988349","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5988349?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.1038/nature25462","host_type":""},{"url":"https://europepmc.org/articles/pmc5988349?pdf=render","host_type":""},{"url":"https://doi.org/10.1101/183160","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/29420470","host_type":""},{"url":"http://dx.doi.org/10.1038/nature25462","host_type":""},{"url":"https://dx.doi.org/10.1038/nature25462","host_type":""},{"url":"https://dx.doi.org/10.1101/183160","host_type":""},{"url":"http://dx.doi.org/10.1101/183160","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Microtubules","Animals","Swine","Humans","Mice","Microtubule-Associated Proteins","Adaptor Proteins, Vesicular Transport","Cryoelectron Microscopy","Biological Transport","Movement","Models, Molecular","Dyneins","Dynactin Complex","Single Molecule Imaging"],"keywords":["Models, Molecular","Swine","Movement","Cryoelectron Microscopy","Dyneins","Biological Transport","Dynactin Complex","Microtubules","Article","Single Molecule Imaging","Adaptor Proteins, Vesicular Transport","Mice","Animals","Humans","Microtubule-Associated Proteins"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.26573122.v1","title":"Additional file 1 of Interaction of the Zika virus with the cytoplasmic dynein-1","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26573122","title":"Additional file 1 of Interaction of the Zika virus with the cytoplasmic dynein-1","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"emdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T15:30:02.873590Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}