{"doi":"10.1038/nature14493","title":"Chromothripsis from DNA damage in micronuclei","abstract":null,"journal":"Nature","year":2015,"id":590918,"datarank":11.448041605796119,"base_score":7.099201743553092,"endowment":7.099201743553092,"self_citation_contribution":1.064880261532964,"citation_network_contribution":10.383161344263154,"self_endowment_contribution":1.064880261532964,"citer_contribution":10.383161344263154,"corpus_percentile":null,"corpus_rank":null,"citation_count":1210,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":227879,"name":"Alexander Spektor","orcid":"0000-0002-1085-3205","position":1,"is_corresponding":false},{"id":1511868,"name":"Hauke Cornils","orcid":null,"position":2,"is_corresponding":false},{"id":63893,"name":"Joshua M. Francis","orcid":"0000-0001-5727-7498","position":3,"is_corresponding":false},{"id":1511869,"name":"Emily K. Jackson","orcid":null,"position":4,"is_corresponding":false},{"id":105671,"name":"Shiwei Liu","orcid":null,"position":5,"is_corresponding":false},{"id":107871,"name":"Matthew Meyerson","orcid":"0000-0002-9133-8108","position":6,"is_corresponding":false},{"id":108498,"name":"David Pellman","orcid":"0000-0001-5306-8031","position":7,"is_corresponding":false},{"id":14276,"name":"Cheng-Zhong Zhang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Chromothripsis from DNA damage in micronuclei","abstract":"Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromothripsis is unknown, but we previously proposed that it could occur through the physical isolation of chromosomes in aberrant nuclear structures called micronuclei. Here, using a combination of live cell imaging and single-cell genome sequencing, we demonstrate that micronucleus formation can indeed generate a spectrum of genomic rearrangements, some of which recapitulate all known features of chromothripsis. These events are restricted to the mis-segregated chromosome and occur within one cell division. We demonstrate that the mechanism for chromothripsis can involve the fragmentation and subsequent reassembly of a single chromatid from a micronucleus. Collectively, these experiments establish a new mutational process of which chromothripsis is one extreme outcome.","is_dataset_classified":null,"base_score":7.099201743553092,"endowment":7.099201743553092,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26017310","pmcid":"PMC4742237","openalex_id":"https://openalex.org/W1601755300","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM083299","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM083299-18","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM061345","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R37 GM061345","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01GM083299-17","title":"Polyploidy, aneuploidy and genome stability"},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":7,"fwci":34.8289,"citation_percentile":0.99876019,"influential_citations":0,"citation_trend":[{"year":2015,"count":36},{"year":2016,"count":92},{"year":2017,"count":92},{"year":2018,"count":119},{"year":2019,"count":100},{"year":2020,"count":125},{"year":2021,"count":148},{"year":2022,"count":118},{"year":2023,"count":109},{"year":2024,"count":119},{"year":2025,"count":98},{"year":2026,"count":53}],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:25658470","host_type":"repository"},{"url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:25658470","host_type":"repository"},{"url":"http://www.nature.com/articles/nature14493.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nature14493","host_type":"publisher"},{"url":"https://doi.org/10.1038/nature14493","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26017310","host_type":"repository"},{"url":"https://www.nature.com/articles/nature14493","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4742237","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4742237","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4742237?pdf=render","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/pmc4742237?pdf=render","host_type":""},{"url":"http://dx.doi.org/10.1038/nature14493","host_type":""},{"url":"https://dx.doi.org/10.1038/nature14493","host_type":""},{"url":"https://doi.org/https://doi.org/10.1038/nature14493","host_type":""}],"fields_of_study":["Cancer Genomics and Diagnostics","DNA Repair Mechanisms","Genomic variations and chromosomal abnormalities","0301 basic medicine","0303 health sciences","03 medical and health sciences","Cell Line","Cell Survival","Chromosome Breakage","Chromosome Segregation","DNA Copy Number Variations","DNA Damage","Gene Rearrangement","Genomic Instability","Humans","Micronuclei, Chromosome-Defective","Mutation","Neoplasms","S Phase","Single-Cell Analysis"],"mesh_terms":["Cell Line","Cell Survival","DNA Damage","Humans","Mutation","Neoplasms","Gene Rearrangement","S Phase","Chromosome Breakage","Chromosome Segregation","Genomic Instability","Micronuclei, Chromosome-Defective","DNA Copy Number Variations","Single-Cell Analysis"],"keywords":["Chromothripsis","Biology","Genetics","Chromosome","Centromere","Genome instability","Chromoplexy","DNA","Cancer","DNA damage","Gene","Gene Rearrangement","570","DNA Copy Number Variations","Cell Survival","610","Chromosome Breakage","Article","Genomic Instability","Cell Line","S Phase","Chromosome Segregation","Neoplasms","Mutation","Humans","Single-Cell Analysis","Micronuclei, Chromosome-Defective"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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