{"doi":"10.1038/nature13980","title":"Piezo2 is the major transducer of mechanical forces for touch sensation in mice","abstract":null,"journal":"Nature","year":2014,"id":656753,"datarank":1.0292567010721096,"base_score":6.86171134048073,"endowment":6.86171134048073,"self_citation_contribution":1.0292567010721096,"citation_network_contribution":0.0,"self_endowment_contribution":1.0292567010721096,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":954,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":14,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":560059,"name":"Seung-Hyun Woo","orcid":null,"position":1,"is_corresponding":false},{"id":560541,"name":"Adrienne E. Dubin","orcid":"0000-0003-4683-7175","position":2,"is_corresponding":false},{"id":1714350,"name":"Rabih A. Moshourab","orcid":null,"position":3,"is_corresponding":false},{"id":1714351,"name":"Christiane Wetzel","orcid":null,"position":4,"is_corresponding":false},{"id":1714352,"name":"Matt Petrus","orcid":null,"position":5,"is_corresponding":false},{"id":1714353,"name":"Jayanti Mathur","orcid":null,"position":6,"is_corresponding":false},{"id":1714354,"name":"Valérie Bégay","orcid":null,"position":7,"is_corresponding":false},{"id":1714355,"name":"Bertrand Coste","orcid":null,"position":8,"is_corresponding":false},{"id":1714356,"name":"James Mainquist","orcid":null,"position":9,"is_corresponding":false},{"id":532574,"name":"A. J. Wilson","orcid":null,"position":10,"is_corresponding":false},{"id":1714357,"name":"Allain G. Francisco","orcid":null,"position":11,"is_corresponding":false},{"id":1714358,"name":"Kritika Reddy","orcid":null,"position":12,"is_corresponding":false},{"id":302485,"name":"Zhaozhu Qiu","orcid":"0000-0002-9122-6077","position":13,"is_corresponding":false},{"id":1198866,"name":"John N. Wood","orcid":"0000-0002-9166-8158","position":14,"is_corresponding":false},{"id":304300,"name":"Gary R. Lewin","orcid":"0000-0002-2890-6352","position":15,"is_corresponding":false},{"id":212337,"name":"Ardem Patapoutian","orcid":null,"position":16,"is_corresponding":false},{"id":278559,"name":"Sanjeev S. Ranade","orcid":"0000-0001-8601-3563","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Piezo2 is the major transducer of mechanical forces for touch sensation in mice","abstract":"The sense of touch provides critical information about our physical environment by transforming mechanical energy into electrical signals. It is postulated that mechanically activated cation channels initiate touch sensation, but the identity of these molecules in mammals has been elusive. Piezo2 is a rapidly adapting, mechanically activated ion channel expressed in a subset of sensory neurons of the dorsal root ganglion and in cutaneous mechanoreceptors known as Merkel-cell-neurite complexes. It has been demonstrated that Merkel cells have a role in vertebrate mechanosensation using Piezo2, particularly in shaping the type of current sent by the innervating sensory neuron; however, major aspects of touch sensation remain intact without Merkel cell activity. Here we show that mice lacking Piezo2 in both adult sensory neurons and Merkel cells exhibit a profound loss of touch sensation. We precisely localize Piezo2 to the peripheral endings of a broad range of low-threshold mechanoreceptors that innervate both hairy and glabrous skin. Most rapidly adapting, mechanically activated currents in dorsal root ganglion neuronal cultures are absent in Piezo2 conditional knockout mice, and ex vivo skin nerve preparation studies show that the mechanosensitivity of low-threshold mechanoreceptors strongly depends on Piezo2. This cellular phenotype correlates with an unprecedented behavioural phenotype: an almost complete deficit in light-touch sensation in multiple behavioural assays, without affecting other somatosensory functions. Our results highlight that a single ion channel that displays rapidly adapting, mechanically activated currents in vitro is responsible for the mechanosensitivity of most low-threshold mechanoreceptor subtypes involved in innocuous touch sensation. Notably, we find that touch and pain sensation are separable, suggesting that as-yet-unknown mechanically activated ion channel(s) must account for noxious (painful) mechanosensation.","is_dataset_classified":null,"base_score":6.86171134048073,"endowment":6.86171134048073,"datacite_reuse_total":14,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25471886","pmcid":"PMC4380172","openalex_id":"https://openalex.org/W2083824794","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"101054","title":null},{"funder_name":"Wellcome Trust","grant_id":"101054/Z/13/Z","title":null},{"funder_name":"Medical Research Council","grant_id":"G0901905","title":null},{"funder_name":"NIDCR NIH HHS","grant_id":"R01 DE022358","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"BB/F000227/1","title":null},{"funder_name":"Versus Arthritis","grant_id":"20200","title":null},{"funder_name":"European Research Council","grant_id":"294678","title":"Molecular exploitation of an extremophile mammal"},{"funder_name":"National Institutes of Health","grant_id":"5R01DE022358-08","title":"Role of mechanically activated ion channels in somatosensation"},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":10,"fwci":24.012,"citation_percentile":0.99786511,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2015,"count":34},{"year":2016,"count":53},{"year":2017,"count":58},{"year":2018,"count":61},{"year":2019,"count":74},{"year":2020,"count":86},{"year":2021,"count":95},{"year":2022,"count":120},{"year":2023,"count":93},{"year":2024,"count":113},{"year":2025,"count":98},{"year":2026,"count":66}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://www.nature.com/articles/nature13980.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nature13980","host_type":"publisher"},{"url":"https://doi.org/10.1038/nature13980","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25471886","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4380172","host_type":"repository"},{"url":"https://amu.hal.science/hal-03464375","host_type":"repository"},{"url":"https://www.nature.com/articles/nature13980","host_type":"repository"},{"url":"http://edoc.mdc-berlin.de/14490/","host_type":"repository"},{"url":"http://discovery.ucl.ac.uk/1467944/","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc4380172?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.1038/nature13980","host_type":""},{"url":"https://amu.hal.science/hal-03464375v1","host_type":""}],"fields_of_study":["Erythrocyte Function and Pathophysiology","Ion channel regulation and function","Ion Channels and Receptors","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Ion Channels","Mechanoreceptors","Mechanotransduction, Cellular","Merkel Cells","Mice","Mice, Knockout","Sensory Receptor Cells","Skin","Touch"],"mesh_terms":["Animals","Ion Channels","Mechanoreceptors","Sensory Receptor Cells","Skin","Touch","Mice, Knockout","Merkel Cells","Mechanotransduction, Cellular","Mice"],"keywords":["Mechanosensation","Mechanoreceptor","Merkel cell","Sensation","Sensory system","Mechanotransduction","Neuroscience","Dorsal root ganglion","Somatosensory system","Biology","Anatomy","Ion channel","Receptor","Mice, Knockout","Sensory Receptor Cells","Mechanotransduction, Cellular","Ion Channels","Merkel Cells","[SDV] Life Sciences [q-bio]","Mice","Touch","Animals","Mechanoreceptors","Skin"],"sdg_mappings":[{"sdg_number":2,"sdg_label":"2. 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