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Factors at different levels have different properties; for instance, top-level transcription factors more strongly influence expression and middle-level ones co-regulate targets to mitigate information-flow bottlenecks. Moreover, these co-regulations give rise to many enriched network motifs (for example, noise-buffering feed-forward loops). Finally, more connected network components are under stronger selection and exhibit a greater degree of allele-specific activity (that is, differential binding to the two parental alleles). The regulatory information obtained in this study will be crucial for interpreting personal genome sequences and understanding basic principles of human biology and disease.","journal":"Nature","year":2012,"id":8866,"datarank":1.1018047260625305,"base_score":7.3453648404168685,"endowment":7.3453648404168685,"self_citation_contribution":1.1018047260625305,"citation_network_contribution":0.0,"self_endowment_contribution":1.1018047260625305,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1548,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.4479,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2012-09-01","fair_score":80.0,"fair_percentile":99.0,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":360,"name":"Anshul Kundaje","orcid":"0000-0003-3084-2287","position":1,"is_corresponding":false},{"id":36424,"name":"Manoj Hariharan","orcid":"0000-0002-1006-5372","position":2,"is_corresponding":false},{"id":62227,"name":"Stephen G. 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