{"doi":"10.1038/nature10369","title":"Crystal structure of nucleotide-free dynamin","abstract":null,"journal":"Nature","year":2011,"id":645352,"datarank":0.8614504781714225,"base_score":5.7430031878094825,"endowment":5.7430031878094825,"self_citation_contribution":0.8614504781714225,"citation_network_contribution":0.0,"self_endowment_contribution":0.8614504781714225,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":311,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1450162,"name":"York Posor","orcid":"0000-0002-4699-5715","position":1,"is_corresponding":false},{"id":583152,"name":"Song Gao","orcid":"0000-0001-7427-6681","position":2,"is_corresponding":false},{"id":1680366,"name":"Martin Held","orcid":null,"position":3,"is_corresponding":false},{"id":1680367,"name":"Yvette Roske","orcid":null,"position":4,"is_corresponding":false},{"id":1680368,"name":"Dennis Schulze","orcid":null,"position":5,"is_corresponding":false},{"id":71008,"name":"Volker Haucke","orcid":"0000-0003-3119-6993","position":6,"is_corresponding":false},{"id":278068,"name":"Frank Noé","orcid":"0000-0003-4169-9324","position":7,"is_corresponding":false},{"id":656510,"name":"Oliver Daumke","orcid":"0000-0002-6190-1414","position":8,"is_corresponding":false},{"id":1680365,"name":"Katja Faelber","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Crystal structure of nucleotide-free dynamin","abstract":"Dynamin is a mechanochemical GTPase that oligomerizes around the neck of clathrin-coated pits and catalyses vesicle scission in a GTP-hydrolysis-dependent manner. The molecular details of oligomerization and the mechanism of the mechanochemical coupling are currently unknown. Here we present the crystal structure of human dynamin 1 in the nucleotide-free state with a four-domain architecture comprising the GTPase domain, the bundle signalling element, the stalk and the pleckstrin homology domain. Dynamin 1 oligomerized in the crystals via the stalks, which assemble in a criss-cross fashion. The stalks further interact via conserved surfaces with the pleckstrin homology domain and the bundle signalling element of the neighbouring dynamin molecule. This intricate domain interaction rationalizes a number of disease-related mutations in dynamin 2 and suggests a structural model for the mechanochemical coupling that reconciles previous models of dynamin function.","is_dataset_classified":null,"base_score":5.7430031878094825,"endowment":5.7430031878094825,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21927000","pmcid":null,"openalex_id":"https://openalex.org/W2094123735","authors":[],"funders":[{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"25065445/SFB 740","title":"From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells"}],"total_grants":1,"fwci":13.7711,"citation_percentile":0.99596225,"influential_citations":0,"citation_trend":[{"year":2012,"count":32},{"year":2013,"count":35},{"year":2014,"count":38},{"year":2015,"count":21},{"year":2016,"count":16},{"year":2017,"count":21},{"year":2018,"count":29},{"year":2019,"count":22},{"year":2020,"count":13},{"year":2021,"count":20},{"year":2022,"count":20},{"year":2023,"count":14},{"year":2024,"count":8},{"year":2025,"count":13},{"year":2026,"count":4}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"http://www.nature.com/articles/nature10369.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nature10369","host_type":"publisher"},{"url":"https://doi.org/10.1038/nature10369","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21927000","host_type":"repository"},{"url":"https://www.nature.com/articles/nature10369","host_type":"repository"},{"url":"http://edoc.mdc-berlin.de/11835/","host_type":"repository"},{"url":"http://discovery.ucl.ac.uk/1486267/","host_type":"repository"},{"url":"https://www.helmholtz-berlin.de/pubbin/oai_publication?VT=1&ID=75893","host_type":"repository"},{"url":"https://dx.doi.org/10.1038/nature10369","host_type":""}],"fields_of_study":["Cellular transport and secretion","Erythrocyte Function and Pathophysiology","Lipid Membrane Structure and Behavior","0301 basic medicine","0303 health sciences","03 medical and health sciences","Crystallography, X-Ray","Dynamin I","Dynamin II","GTP Phosphohydrolases","Guanosine Triphosphate","HeLa Cells","Humans","Hydrolysis","Models, Molecular","Molecular Dynamics Simulation","Nucleotides","Protein Binding","Protein Structure, Tertiary","Signal Transduction","Transferrin"],"mesh_terms":["Guanosine Triphosphate","HeLa Cells","Humans","Hydrolysis","Models, Molecular","Nucleotides","Protein Binding","Transferrin","Signal Transduction","Protein Structure, Tertiary","Crystallography, X-Ray","GTP Phosphohydrolases","Dynamin I","Dynamin II","Molecular Dynamics Simulation","Hela Cells"],"keywords":["Dynamin","Pleckstrin homology domain","GTPase","GTP'","Nucleotide","Protein structure","Biophysics","Crystallography","Stereochemistry","Chemistry","Biochemistry","Endocytosis","Biology","Enzyme","Signal transduction","Models, Molecular","Nucleotides","Hydrolysis","Transferrin","Molecular Dynamics Simulation","Crystallography, X-Ray","GTP Phosphohydrolases","Protein Structure, Tertiary","Dynamin II","Humans","Guanosine Triphosphate","Dynamin I","HeLa Cells","Protein Binding"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T05:01:34.534209Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}