{"doi":"10.1038/nature09820","title":"Amygdala circuitry mediating reversible and bidirectional control of anxiety","abstract":null,"journal":"Nature","year":2011,"id":590003,"datarank":14.819794624838355,"base_score":7.186144304522325,"endowment":7.186144304522325,"self_citation_contribution":1.077921645678349,"citation_network_contribution":13.741872979160007,"self_endowment_contribution":1.077921645678349,"citer_contribution":13.741872979160007,"corpus_percentile":null,"corpus_rank":null,"citation_count":1320,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":12,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":201398,"name":"Rohit Prakash","orcid":null,"position":1,"is_corresponding":false},{"id":1507317,"name":"Sung-Yon Kim","orcid":"0000-0003-0791-7308","position":2,"is_corresponding":false},{"id":249615,"name":"Lief E. Fenno","orcid":"0000-0002-5237-6179","position":3,"is_corresponding":false},{"id":1043000,"name":"Logan Grosenick","orcid":"0000-0003-3216-0319","position":4,"is_corresponding":false},{"id":1509588,"name":"Hosniya Zarabi","orcid":null,"position":5,"is_corresponding":false},{"id":1509589,"name":"Kimberly R. Thompson","orcid":null,"position":6,"is_corresponding":false},{"id":228771,"name":"Viviana Gradinaru","orcid":"0000-0001-5868-348X","position":7,"is_corresponding":false},{"id":249310,"name":"Charu Ramakrishnan","orcid":"0000-0002-3474-6332","position":8,"is_corresponding":false},{"id":169424,"name":"Karl Deisseroth","orcid":null,"position":9,"is_corresponding":false},{"id":164503,"name":"Kay M. Tye","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Amygdala circuitry mediating reversible and bidirectional control of anxiety","abstract":"Anxiety--a sustained state of heightened apprehension in the absence of immediate threat--becomes severely debilitating in disease states. Anxiety disorders represent the most common of psychiatric diseases (28% lifetime prevalence) and contribute to the aetiology of major depression and substance abuse. Although it has been proposed that the amygdala, a brain region important for emotional processing, has a role in anxiety, the neural mechanisms that control anxiety remain unclear. Here we explore the neural circuits underlying anxiety-related behaviours by using optogenetics with two-photon microscopy, anxiety assays in freely moving mice, and electrophysiology. With the capability of optogenetics to control not only cell types but also specific connections between cells, we observed that temporally precise optogenetic stimulation of basolateral amygdala (BLA) terminals in the central nucleus of the amygdala (CeA)--achieved by viral transduction of the BLA with a codon-optimized channelrhodopsin followed by restricted illumination in the downstream CeA--exerted an acute, reversible anxiolytic effect. Conversely, selective optogenetic inhibition of the same projection with a third-generation halorhodopsin (eNpHR3.0) increased anxiety-related behaviours. Importantly, these effects were not observed with direct optogenetic control of BLA somata, possibly owing to recruitment of antagonistic downstream structures. Together, these results implicate specific BLA-CeA projections as critical circuit elements for acute anxiety control in the mammalian brain, and demonstrate the importance of optogenetically targeting defined projections, beyond simply targeting cell types, in the study of circuit function relevant to neuropsychiatric disease.","is_dataset_classified":null,"base_score":7.186144304522325,"endowment":7.186144304522325,"datacite_reuse_total":12,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21389985","pmcid":"PMC3154022","openalex_id":"https://openalex.org/W2060978874","authors":[],"funders":[{"funder_name":"NIH HHS","grant_id":"DP1 OD000616","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"F32 MH088010","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"1F32MH088010-01","title":"The effects of thalamoamygdalar synaptic potentiation on learning performance"},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH075957","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"DP2 DK102256","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA020794","title":null},{"funder_name":"National Science Foundation","grant_id":"0801700","title":"IGERT: Emergent Functions of Neural Systems"}],"total_grants":7,"fwci":32.0657,"citation_percentile":0.99955639,"influential_citations":0,"citation_trend":[{"year":2012,"count":87},{"year":2013,"count":77},{"year":2014,"count":91},{"year":2015,"count":100},{"year":2016,"count":99},{"year":2017,"count":70},{"year":2018,"count":86},{"year":2019,"count":87},{"year":2020,"count":98},{"year":2021,"count":110},{"year":2022,"count":89},{"year":2023,"count":79},{"year":2024,"count":90},{"year":2025,"count":76},{"year":2026,"count":41}],"oa_status":"green","license":"Springer TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3154022","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3154022","host_type":"repository"},{"url":"http://www.nature.com/articles/nature09820.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nature09820","host_type":"publisher"},{"url":"https://doi.org/10.1038/nature09820","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21389985","host_type":"repository"},{"url":"https://resolver.caltech.edu/CaltechAUTHORS:20121206-133910388","host_type":"repository"},{"url":"https://www.nature.com/articles/nature09820","host_type":"repository"},{"url":"https://hdl.handle.net/10371/192608","host_type":"repository"},{"url":"http://hdl.handle.net/10371/95393","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc3154022?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.1038/nature09820","host_type":""},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3154022/","host_type":""},{"url":"https://doi.org/https://doi.org/10.1038/nature09820","host_type":""}],"fields_of_study":["Photoreceptor and optogenetics research","Neuroscience and Neuropharmacology Research","Circadian rhythm and melatonin","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Amygdala","Animals","Anxiety","Anxiety Disorders","Light","Models, Neurological","Neural Pathways","Neurons","Stress, Physiological","Synapses","Halorhodopsins","Mice"],"keywords":["Amygdala","Optogenetics","Basolateral amygdala","Anxiety","Neuroscience","Psychology","Central nucleus of the amygdala","Deep brain stimulation","Medicine","Psychiatry","Internal medicine","Disease","Parkinson's disease","Neurons","570","Light","Models, Neurological","Anxiety Disorders","Mice","Stress, Physiological","Neural Pathways","Synapses","Animals","Halorhodopsins"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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