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We find that membrane insertion depends strongly on the position of polar residues within transmembrane segments, adding a new dimension to the problem of predicting transmembrane helices from amino acid sequences. Our results indicate that direct protein-lipid interactions are critical during translocon-mediated membrane insertion.","is_dataset_classified":null,"base_score":6.93537044601511,"endowment":6.93537044601511,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15674282","pmcid":null,"openalex_id":"https://openalex.org/W2025859600","authors":[],"funders":[],"total_grants":0,"fwci":27.6755,"citation_percentile":0.99877523,"influential_citations":71,"citation_trend":[{"year":2012,"count":60},{"year":2013,"count":63},{"year":2014,"count":66},{"year":2015,"count":46},{"year":2016,"count":37},{"year":2017,"count":43},{"year":2018,"count":45},{"year":2019,"count":37},{"year":2020,"count":34},{"year":2021,"count":40},{"year":2022,"count":23},{"year":2023,"count":27},{"year":2024,"count":30},{"year":2025,"count":27},{"year":2026,"count":22}],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"https://escholarship.org/uc/item/4847p8dx","host_type":"repository"},{"url":"https://escholarship.org/uc/item/4847p8dx","host_type":"GREEN"},{"url":"https://escholarship.org/uc/item/4847p8dx","host_type":"repository"},{"url":"http://www.nature.com/articles/nature03216.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/nature03216","host_type":"publisher"},{"url":"https://doi.org/10.1038/nature03216","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15674282","host_type":"repository"},{"url":"https://www.nature.com/articles/nature03216","host_type":"repository"}],"fields_of_study":["RNA and protein synthesis mechanisms","Lipid Membrane Structure and Behavior","Bacterial Genetics and Biotechnology","Chemistry","Medicine","Biology"],"mesh_terms":["SEC Translocation Channels","Amino Acid Sequence","Amino Acids","Animals","Cell Line","Cell Membrane","Endoplasmic Reticulum","Cricetinae","Membrane Proteins","Molecular Sequence Data","Peptide Fragments","Thermodynamics","Protein Structure, Secondary","Protein Transport","Lipid Metabolism","Static Electricity","Hydrophobic and Hydrophilic Interactions"],"keywords":["Translocon","Sec61","Transmembrane protein","Endoplasmic reticulum","Transmembrane domain","Membrane protein","STIM1","Integral membrane protein","Chemistry","Membrane","Biology","Biophysics","Biochemistry","Cell biology"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.17304753.v1","title":"Additional file 1 of pyKVFinder: an efficient and integrable Python package for biomolecular cavity detection and characterization in data science","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.17304753","title":"Additional file 1 of pyKVFinder: an efficient and integrable Python package for biomolecular cavity detection and characterization in data science","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26661014.v1","title":"Additional file 1 of Prop3D: A flexible, Python-based platform for machine learning with protein structural properties and biophysical data","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26661014","title":"Additional file 1 of Prop3D: A flexible, Python-based platform for machine learning with protein structural properties and biophysical data","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T02:18:37.957214Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}