{"doi":"10.1038/mp.2016.164","title":"Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia","abstract":null,"journal":"Molecular Psychiatry","year":2016,"id":599682,"datarank":0.6610078870896381,"base_score":4.406719247264253,"endowment":4.406719247264253,"self_citation_contribution":0.6610078870896381,"citation_network_contribution":0.0,"self_endowment_contribution":0.6610078870896381,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":81,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1536945,"name":"J T Baker","orcid":null,"position":1,"is_corresponding":false},{"id":1536946,"name":"A J Holmes","orcid":null,"position":2,"is_corresponding":false},{"id":1536947,"name":"N Jahanshad","orcid":null,"position":3,"is_corresponding":false},{"id":1536948,"name":"T Ge","orcid":null,"position":4,"is_corresponding":false},{"id":1536949,"name":"J-Y Jung","orcid":null,"position":5,"is_corresponding":false},{"id":1536950,"name":"Y Cruz","orcid":null,"position":6,"is_corresponding":false},{"id":1536951,"name":"D S Manoach","orcid":null,"position":7,"is_corresponding":false},{"id":1536952,"name":"D P Hibar","orcid":null,"position":8,"is_corresponding":false},{"id":1536953,"name":"J Faskowitz","orcid":null,"position":9,"is_corresponding":false},{"id":1536955,"name":"K L McMahon","orcid":null,"position":10,"is_corresponding":false},{"id":1536957,"name":"G I de Zubicaray","orcid":null,"position":11,"is_corresponding":false},{"id":1536958,"name":"N H Martin","orcid":null,"position":12,"is_corresponding":false},{"id":1536959,"name":"M J Wright","orcid":null,"position":13,"is_corresponding":false},{"id":1536960,"name":"D Öngür","orcid":null,"position":14,"is_corresponding":false},{"id":1536961,"name":"R Buckner","orcid":null,"position":15,"is_corresponding":false},{"id":1536963,"name":"J Roffman","orcid":null,"position":16,"is_corresponding":false},{"id":1536964,"name":"P M Thompson","orcid":null,"position":17,"is_corresponding":false},{"id":1536965,"name":"J W Smoller","orcid":null,"position":18,"is_corresponding":false},{"id":1536944,"name":"P H Lee","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia","abstract":"Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic etiology. Widespread cortical gray matter loss has been observed in patients and prodromal samples. However, it remains unresolved whether schizophrenia-associated cortical structure variations arise due to disease etiology or secondary to the illness. Here we address this question using a partitioning-based heritability analysis of genome-wide single-nucleotide polymorphism (SNP) and neuroimaging data from 1750 healthy individuals. We find that schizophrenia-associated genetic variants explain a significantly enriched proportion of trait heritability in eight brain phenotypes (false discovery rate=10%). In particular, intracranial volume and left superior frontal gyrus thickness exhibit significant and robust associations with schizophrenia genetic risk under varying SNP selection conditions. Cross-disorder comparison suggests that the neurogenetic architecture of schizophrenia-associated brain regions is, at least in part, shared with other psychiatric disorders. Our study highlights key neuroanatomical correlates of schizophrenia genetic risk in the general population. These may provide fundamental insights into the complex pathophysiology of the illness, and a potential link to neurocognitive deficits shaping the disorder.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27725656","pmcid":"PMC5144575","openalex_id":null,"authors":[],"funders":[{"funder_name":"NICHD NIH HHS","grant_id":"R01 HD050735","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"K24 MH094614","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R00 MH101367","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"K23 MH104515","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH101486","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"K01 MH099232","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"K99 MH101367","title":null},{"funder_name":"NIBIB NIH HHS","grant_id":"U54 EB020403","title":null},{"funder_name":"National Health and Medical Research Council (NHMRC)","grant_id":"1009064","title":"Genetics of brain structure and function"},{"funder_name":"National Health and Medical Research Council (NHMRC)","grant_id":"389875","title":"Genetics of melanoma risk factors"},{"funder_name":"National Institutes of Health","grant_id":"5R01HD050735-02","title":"Genetic influences on the brain: A twin imaging study"},{"funder_name":"National Institutes of Health","grant_id":"5K99MH101367-02","title":"Neuroimaging genetics to study social cognitive deficits in ASD and schizophrenia"},{"funder_name":"National Institutes of Health","grant_id":"4R01MH101486-04","title":"Neural and Genetic Basis of Negative Valance Traits"},{"funder_name":"National Institutes of Health","grant_id":"4K24MH094614-05","title":"Research and Mentoring on Integrating Psychiatric Genetics and Neuroscience"},{"funder_name":"National Institutes of Health","grant_id":"1K23MH104515-01","title":"Frontoparietal Network Integrity and Risk for Psychosis"},{"funder_name":"National Institutes of Health","grant_id":"5K01MH099232-03","title":"Dimensional Neurogenetic Markers of Limbic System Integrity & Psychiatric Illness"},{"funder_name":"National Institutes of Health","grant_id":"5U54EB020403-03","title":"ENIGMA Center for Worldwide Medicine, Imaging & Genomics"}],"total_grants":17,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"https://www.nature.com/articles/mp2016164.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/mp2016164","host_type":"publisher"},{"url":"https://doi.org/10.1038/mp.2017.42","host_type":""},{"url":"https://www.nature.com/articles/mp201742.pdf","host_type":""},{"url":"https://doi.org/10.1038/mp.2016.164","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/28220043","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/27725656","host_type":""},{"url":"https://api.library.uq.edu.au/view/UQ:413904","host_type":""},{"url":"https://espace.library.uq.edu.au/view/UQ:413904","host_type":""},{"url":"https://dx.doi.org/10.1038/mp.2016.164","host_type":""},{"url":"https://doi.org/https://doi.org/10.1038/mp.2016.164","host_type":""}],"fields_of_study":["0301 basic medicine","03 medical and health sciences","0303 health sciences"],"mesh_terms":["Brain","Humans","Genetic Predisposition to Disease","Magnetic Resonance Imaging","Risk Factors","Schizophrenia","Polymorphism, Single Nucleotide","Adolescent","Adult","Female","Male","Genome-Wide Association Study","Gray Matter"],"keywords":["Adult","Male","Biochemistry & Molecular Biology","Adolescent","150","2804 Cellular and Molecular Neuroscience","610","Polymorphism, Single Nucleotide","Risk Factors","616","2738 Psychiatry and Mental health","1312 Molecular Biology","Humans","Genetic Predisposition to Disease","Gray Matter","Psychiatry","Neurosciences","Brain","Magnetic Resonance Imaging","Schizophrenia","Female","Neurosciences & Neurology","Genome-Wide Association Study"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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