{"doi":"10.1038/ki.2009.479","title":"Commonly used surrogates for baseline renal function affect the classification and prognosis of acute kidney injury","abstract":null,"journal":"Kidney International","year":2010,"id":655644,"datarank":0.8419692159582107,"base_score":5.6131281063880705,"endowment":5.6131281063880705,"self_citation_contribution":0.8419692159582107,"citation_network_contribution":0.0,"self_endowment_contribution":0.8419692159582107,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":273,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":11398,"name":"Michael E. Matheny","orcid":"0000-0003-3217-4147","position":1,"is_corresponding":false},{"id":930348,"name":"T. Alp Ikizler","orcid":null,"position":2,"is_corresponding":false},{"id":792420,"name":"Julie B. Lewis","orcid":null,"position":3,"is_corresponding":false},{"id":1131470,"name":"Randolph A. Miller","orcid":null,"position":4,"is_corresponding":false},{"id":270871,"name":"Lemuel R. Waitman","orcid":"0000-0003-4748-2898","position":5,"is_corresponding":false},{"id":249669,"name":"Alan S. Go","orcid":"0000-0001-9109-0811","position":6,"is_corresponding":false},{"id":241229,"name":"Chirag R. Parikh","orcid":"0000-0001-9051-7385","position":7,"is_corresponding":false},{"id":404442,"name":"Josh F. Peterson","orcid":"0000-0002-7553-0749","position":8,"is_corresponding":false},{"id":249668,"name":"Edward D. Siew","orcid":"0000-0003-1343-8784","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Commonly used surrogates for baseline renal function affect the classification and prognosis of acute kidney injury","abstract":"Studies of acute kidney injury usually lack data on pre-admission kidney function and often substitute an inpatient or imputed serum creatinine as an estimate for baseline renal function. In this study, we compared the potential error introduced by using surrogates such as (1) an estimated glomerular filtration rate of 75 ml/min per 1.73 m(2) (suggested by the Acute Dialysis Quality Initiative), (2) a minimum inpatient serum creatinine value, and (3) the first admission serum creatinine value, with values computed using pre-admission renal function. The study covered a 12-month period and included a cohort of 4863 adults admitted to the Vanderbilt University Hospital. Use of both imputed and minimum baseline serum creatinine values significantly inflated the incidence of acute kidney injury by about half, producing low specificities of 77-80%. In contrast, use of the admission serum creatinine value as baseline significantly underestimated the incidence by about a third, yielding a low sensitivity of 39%. Application of any surrogate marker led to frequent misclassification of patient deaths after acute kidney injury and differences in both in-hospital and 60-day mortality rates. Our study found that commonly used surrogates for baseline serum creatinine result in bi-directional misclassification of the incidence and prognosis of acute kidney injury in a hospital setting.","is_dataset_classified":null,"base_score":5.6131281063880705,"endowment":5.6131281063880705,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20042998","pmcid":"PMC2929703","openalex_id":"https://openalex.org/W1987417671","authors":[],"funders":[{"funder_name":"NCRR NIH HHS","grant_id":"KL2 RR024977","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"U01 DK082185","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"U01 DK082223","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"UL1 RR024975","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"U01 DK082192","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"U01DK82192","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"5U01DK082223-02","title":"Prospective Evaluation of Acute Kidney Injury (PEAK) Cohort"},{"funder_name":"NIDDK NIH HHS","grant_id":"K24 DK62849","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"1UL-1RR024975","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"5U01DK082185-02","title":"Progression of Acute Kidney Injury to Chonic Kidney Disease"},{"funder_name":"NIDDK NIH HHS","grant_id":"5U01DK082192-02","title":"Impact of Acute Kidney Injury on Kidney Disease Progression"},{"funder_name":"NCRR NIH HHS","grant_id":"5KL2 RR024977","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"K24 DK062849","title":null},{"funder_name":"NLM NIH HHS","grant_id":"R01 LM009965","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01LM009965-03","title":"Information Systems for Detecting and Managing Acute Kidney Injury"},{"funder_name":"National Institutes of Health","grant_id":"5KL2RR024977-03","title":"The Vanderbilt Institute for Clinical and Translational Research (VICTR) KL2"},{"funder_name":"National Institutes of Health","grant_id":"5K24DK062849-10","title":"Nutrition and Metabolism in Dialysis Patients"}],"total_grants":17,"fwci":5.87,"citation_percentile":0.96792556,"influential_citations":0,"citation_trend":[{"year":2012,"count":21},{"year":2013,"count":12},{"year":2014,"count":19},{"year":2015,"count":23},{"year":2016,"count":22},{"year":2017,"count":22},{"year":2018,"count":19},{"year":2019,"count":12},{"year":2020,"count":20},{"year":2021,"count":19},{"year":2022,"count":22},{"year":2023,"count":18},{"year":2024,"count":12},{"year":2025,"count":5},{"year":2026,"count":7}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.kidney-international.org/article/S0085253815542907/pdf","host_type":"journal"},{"url":"http://www.kidney-international.org/article/S0085253815542907/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0085253815542907?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0085253815542907?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1038/ki.2009.479","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20042998","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2929703","host_type":"repository"},{"url":"http://dx.doi.org/10.1038/ki.2009.479","host_type":""},{"url":"https://dx.doi.org/10.1038/ki.2009.479","host_type":""}],"fields_of_study":["Acute Kidney Injury Research","Chronic Kidney Disease and Diabetes","Sepsis Diagnosis and Treatment","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Adult","Creatinine","Glomerular Filtration Rate","Renal Dialysis","Humans","Inpatients","Kidney","Kidney Function Tests","Prognosis","Sensitivity and Specificity","Biomarkers","Incidence","Acute Kidney Injury"],"keywords":["Creatinine","Medicine","Acute kidney injury","Renal function","Dialysis","Incidence (geometry)","Kidney disease","Internal medicine","Urology","Intensive care medicine","Adult","Inpatients","diagnosis","Incidence","Kidney","Kidney Function Tests","Prognosis","acute renal failure","Sensitivity and Specificity","Nephrology","Renal Dialysis","mortality risk","Humans","Biomarkers","Glomerular Filtration Rate"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T18:24:18.697156Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}