{"doi":"10.1038/ki.1996.264","title":"Renal brush border membrane Na/Pi-cotransport: Molecular aspects in PTH-dependent and dietary regulation","abstract":null,"journal":"Kidney International","year":1996,"id":673927,"datarank":0.637274286307404,"base_score":4.248495242049359,"endowment":4.248495242049359,"self_citation_contribution":0.637274286307404,"citation_network_contribution":0.0,"self_endowment_contribution":0.637274286307404,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":69,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1760805,"name":"Marius Lötscher","orcid":null,"position":1,"is_corresponding":false},{"id":706849,"name":"Brigitte Kaissling","orcid":null,"position":2,"is_corresponding":false},{"id":838014,"name":"Moshe Levi","orcid":"0000-0002-6225-946X","position":3,"is_corresponding":false},{"id":1760807,"name":"Stephen A. Kempson","orcid":null,"position":4,"is_corresponding":false},{"id":1760808,"name":"Jürg Biber","orcid":null,"position":5,"is_corresponding":false},{"id":1760803,"name":"Heini Murer","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Renal brush border membrane Na/Pi-cotransport: Molecular aspects in PTH-dependent and dietary regulation","abstract":"Inorganic phosphate (Pi) is reabsorbed in renal proximal tubules in a sodium (Na)-dependent manner involving brush border Na/Pi-cotransporter(s). Regulation of renal Pi-reabsorption, such as by parathyroid hormone (PTH) and/or by dietary Pi-deprivation, involves alterations in the rate of Na/Pi-cotransport. Two structurally different Na/Pi-cotransporters have been identified: type I-transporter and type II-transporter. The related mRNAs and proteins are located in the proximal tubule and in the brush border membrane. In heterologous expression systems type I and type II Na/Pi-cotransporters mediate Na/Pi-cotransport. Characterization of the transport properties suggested that the type II transporter is \"responsible' for brush border membrane Na/Pi-cotransport (as observed in isolated vesicles). Administration of PTH to rats resulted in an inhibition of brush border membrane Na/Pi-cotransport (vesicles) and in a reduced brush border membrane content of the type II transporter. Feeding low Pi-diets resulted in an up-regulation of Na/Pi-cotransport (vesicles) and of type II transporter content; only after a prolonged exposure to low Pi-diets (more than 4 hr) was an increase in specific mRNA content observed. Refeeding high Pi diets had the opposite effects on Na/Pi-cotransport activity and on type II transporter protein. It is currently the task of future experiments to define the specific mechanisms leading to protein-synthesis-independent (PTH, acute Pi-deprivation, Pi-refeeding) and to protein-synthesis-dependent (prolonged Pi-deprivation) regulation of the type II Na/Pi-cotransporter.","is_dataset_classified":null,"base_score":4.248495242049359,"endowment":4.248495242049359,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8743494","pmcid":null,"openalex_id":"https://openalex.org/W2039179580","authors":[],"funders":[],"total_grants":0,"fwci":1.4696,"citation_percentile":0.80907469,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":4},{"year":2014,"count":3},{"year":2015,"count":5},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://doi.org/10.1038/ki.1996.264","host_type":"journal"},{"url":"https://doi.org/10.1038/ki.1996.264","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0085253815595586?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0085253815595586?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8743494","host_type":"repository"},{"url":"https://www.zora.uzh.ch/1357","host_type":"repository"}],"fields_of_study":["Parathyroid Disorders and Treatments","Magnesium in Health and Disease","Biomedical Research and Pathophysiology"],"mesh_terms":["Animals","Carrier Proteins","Kidney","Microvilli","Molecular Biology","Parathyroid Hormone","Phosphorus, Dietary","Symporters","Sodium-Phosphate Cotransporter Proteins","Sodium-Phosphate Cotransporter Proteins, Type I","Sodium-Phosphate Cotransporter Proteins, Type II"],"keywords":["Cotransporter","Brush border","Symporter","Transporter","Vesicle","Pi","Chemistry","Endocrinology","Internal medicine","Apical membrane","Reabsorption","Ion transporter","Membrane transport","Biochemistry","Biology","Kidney","Sodium","Membrane","Medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T14:57:32.800755Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}