{"doi":"10.1038/ki.1993.63","title":"Localization of apolipoprotein(a) and B-100 in various renal diseases","abstract":null,"journal":"Kidney International","year":1993,"id":603950,"datarank":0.586803450814222,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.0,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":444995,"name":"Satoru Suzuki","orcid":"0000-0003-2543-7244","position":1,"is_corresponding":false},{"id":1549439,"name":"Mitsuhiro Ueno","orcid":null,"position":2,"is_corresponding":false},{"id":1549440,"name":"Hisaki Shimada","orcid":null,"position":3,"is_corresponding":false},{"id":1549441,"name":"Ryou Karasawa","orcid":null,"position":4,"is_corresponding":false},{"id":1549442,"name":"Shin-Ichi Nishi","orcid":null,"position":5,"is_corresponding":false},{"id":1549443,"name":"Masaaki Arakawa","orcid":null,"position":6,"is_corresponding":false},{"id":1549438,"name":"Hirokazu Sato","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Localization of apolipoprotein(a) and B-100 in various renal diseases","abstract":"Recently it has become clear that abnormalities of lipid metabolism play a large role in the progression of renal diseases. To investigate the relationship between lipids and kidney tissue, we employed an immunofluorescent technique to determine the localization pattern of apolipoprotein(a) [apo(a)], apoB-100, and low-density lipoprotein receptor in the glomeruli, and analyzed the relationship between their presence and the clinical and histological findings of a total 92 patients with glomerular diseases. Immunostaining showed co-localization of apo(a) and apoB-100 in glomeruli. The patients were divided into three groups, as follows: both apo(a) and apoB-100 positive (Group 1; 38 cases), apo(a) positive only (Group 2; 19 cases) and apo(a) negative (Group 3; 35 cases). Group 1 had more severe proteinuria, higher levels of lipoprotein(a) [Lp(a)], and lower total protein levels than Group 3. Group 1 had a higher prevalence of glomerulosclerosis and interstitial changes than Group 3. Group 2 had more severe proteinuria and a higher prevalence of glomerulosclerosis than Group 3. Although apo(a) and apoB-100 are almost absent in normal controls, these apoproteins [and presumably lipoproteins Lp(a)] are present in the glomeruli of patients with glomerular diseases. The data support the view that these apoproteins play a significant role in progressive renal diseases.","is_dataset_classified":null,"base_score":3.912023005428146,"endowment":3.912023005428146,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8441239","pmcid":null,"openalex_id":"https://openalex.org/W2001907249","authors":[],"funders":[],"total_grants":0,"fwci":5.3972,"citation_percentile":0.96394076,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2015,"count":1},{"year":2018,"count":1},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2023,"count":1}],"oa_status":"bronze","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://doi.org/10.1038/ki.1993.63","host_type":"journal"},{"url":"https://doi.org/10.1038/ki.1993.63","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0085253815579441?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0085253815579441?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8441239","host_type":"repository"}],"fields_of_study":["Renal Diseases and Glomerulopathies","Lipoproteins and Cardiovascular Health","Cancer, Lipids, and Metabolism"],"mesh_terms":["Adolescent","Adult","Aged","Apolipoproteins B","Child","Female","Fluorescent Antibody Technique","Humans","Kidney Diseases","Kidney Glomerulus","Male","Middle Aged","Proteinuria","Receptors, LDL","Tissue Distribution","Lipoprotein(a)","Apolipoprotein B-100"],"keywords":["Apolipoprotein B","Glomerulosclerosis","Proteinuria","Lipoprotein","Internal medicine","Endocrinology","Kidney","Focal segmental glomerulosclerosis","Immunostaining","Apolipoprotein E","Nephrotic syndrome","Medicine","Biology","Pathology","Cholesterol","Immunohistochemistry","Disease"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T23:04:32.352889Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}