{"doi":"10.1038/jid.2015.126","title":"Narrow Band Ultraviolet B Treatment for Human Vitiligo Is Associated with Proliferation, Migration, and Differentiation of Melanocyte Precursors","abstract":null,"journal":"Journal of Investigative Dermatology","year":2015,"id":685714,"datarank":0.7193685818395114,"base_score":4.795790545596741,"endowment":4.795790545596741,"self_citation_contribution":0.7193685818395114,"citation_network_contribution":0.0,"self_endowment_contribution":0.7193685818395114,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":120,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":753744,"name":"Maranke I. 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NBUVB was associated with a significant increase in the number of melanocytes in the infundibulum and with restoration of the normal melanocyte population in the epidermis, which was lacking in the untreated vitiligo. We identified several precursor populations (melanocyte stem cells, melanoblasts, and other immature phenotypes), and progressively differentiating melanocytes, some with putative migratory and/or proliferative abilities. The primary melanocyte germ was present in the untreated and treated hair follicle bulge, whereas a possible secondary melanocyte germ composed of C-KIT+ melanocytes was found in the infundibulum and interfollicular epidermis of UV-treated vitiligo. This is an exceptional model for studying the mobilization of melanocyte stem cells in human skin. Improved understanding of this process is essential for designing better treatments for vitiligo, ultimately based on melanocyte stem cell activation and mobilization.","is_dataset_classified":null,"base_score":4.795790545596741,"endowment":4.795790545596741,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25822579","pmcid":"PMC4683025","openalex_id":"https://openalex.org/W1998269575","authors":[],"funders":[{"funder_name":"NIAMS NIH HHS","grant_id":"P30AR057212","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA046934","title":null},{"funder_name":"NCATS NIH HHS","grant_id":"UL1 TR001082","title":null},{"funder_name":"National Institutes of Health","grant_id":"5P30AR057212-03","title":"Molecular Analysis, Modeling and Correction of Skin Diseases"},{"funder_name":"National Institutes of Health","grant_id":"3P30CA046934-20S2","title":"Cancer Center Support Grant"}],"total_grants":5,"fwci":4.9373,"citation_percentile":0.95957447,"influential_citations":0,"citation_trend":[{"year":2015,"count":5},{"year":2016,"count":14},{"year":2017,"count":6},{"year":2018,"count":9},{"year":2019,"count":15},{"year":2020,"count":14},{"year":2021,"count":8},{"year":2022,"count":11},{"year":2023,"count":6},{"year":2024,"count":13},{"year":2025,"count":9},{"year":2026,"count":8}],"oa_status":"closed","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0022202X1539045X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022202X1539045X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1038/jid.2015.126","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25822579","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4683025","host_type":"repository"},{"url":"http://www.jidonline.org/article/S0022202X1539045X/pdf","host_type":""},{"url":"http://dx.doi.org/10.1038/jid.2015.126","host_type":""},{"url":"https://dx.doi.org/10.1038/jid.2015.126","host_type":""}],"fields_of_study":["melanin and skin pigmentation","Herpesvirus Infections and Treatments","RNA regulation and disease","0301 basic medicine","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["PAX3 Transcription Factor","Cell Differentiation","Cell Movement","Epidermis","Humans","Melanocytes","Phenotype","Stem Cells","Ultraviolet Rays","Ultraviolet Therapy","Vitiligo","Hair Follicle","Proto-Oncogene Proteins c-kit","Intramolecular Oxidoreductases","Cell Proliferation","Paired Box Transcription Factors"],"keywords":["Melanocyte","Vitiligo","Biology","Hair follicle","Epidermis (zoology)","Hypopigmentation","Stem cell factor","Melanin","Cell biology","Stem cell","Immunology","Melanoma","Cancer research","Anatomy","Progenitor cell","Genetics","Ultraviolet Rays","Stem Cells","Cell Differentiation","Dermatology","Biochemistry","Intramolecular Oxidoreductases","Proto-Oncogene Proteins c-kit","Phenotype","Cell Movement","Humans","Melanocytes","Paired Box Transcription Factors","Ultraviolet Therapy","Epidermis","Molecular Biology","PAX3 Transcription Factor","Cell Proliferation"],"sdg_mappings":[{"sdg_number":2,"sdg_label":"2. 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