{"doi":"10.1038/jid.2014.176","title":"Decreased Susceptibility of Staphylococcus aureus Small-Colony Variants toward Human Antimicrobial Peptides","abstract":null,"journal":"Journal of Investigative Dermatology","year":2014,"id":643690,"datarank":0.6090664515819629,"base_score":4.060443010546419,"endowment":4.060443010546419,"self_citation_contribution":0.6090664515819629,"citation_network_contribution":0.0,"self_endowment_contribution":0.6090664515819629,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":57,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":791116,"name":"Karsten Becker","orcid":"0000-0002-6391-1341","position":1,"is_corresponding":false},{"id":1674936,"name":"Christof von Eiff","orcid":null,"position":2,"is_corresponding":false},{"id":1674937,"name":"Ulf Meyer-Hoffert","orcid":null,"position":3,"is_corresponding":false},{"id":119640,"name":"Jürgen Harder","orcid":null,"position":4,"is_corresponding":false},{"id":119638,"name":"Regine Gläser","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Decreased Susceptibility of Staphylococcus aureus Small-Colony Variants toward Human Antimicrobial Peptides","abstract":"Staphylococcus aureus is a frequent resident of human nose and skin in many individuals, but it is also able to cause a variety of serious infections including those of the skin and soft tissue. There is increasing evidence that particularly persistent, relapsing, and difficult-to-treat infections caused by S. aureus are associated with the formation of the small-colony variant (SCV) phenotype. The aim of this study was to investigate the hypothesis that (i) skin-derived antimicrobial peptides (AMPs) exhibit a reduced activity against SCVs and (ii) that switching into the SCV phenotype may endow S. aureus with a decreased susceptibility toward the killing activity of human stratum corneum. Here, we show that clinically derived S. aureus SCVs are less susceptible to the bactericidal activity of different human skin-derived AMPs as compared with their isogenic corresponding wild-type strains. Similarly, a S. aureus hemB mutant displaying the SCV phenotype was less susceptible to the antimicrobial activity of AMPs than its hemB-complemented mutant. These findings were accompanied by a higher resistance of SCVs to the killing activity of human stratum corneum. Switching into the SCV phenotype may help S. aureus to subvert cutaneous innate defense, thus contributing to the establishment and persistence of infection.","is_dataset_classified":null,"base_score":4.060443010546419,"endowment":4.060443010546419,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24717245","pmcid":null,"openalex_id":"https://openalex.org/W2042766797","authors":[],"funders":[{"funder_name":"Bundesministerium für Bildung und Forschung","grant_id":"01KI1009A","title":null},{"funder_name":"Bundesministerium für Bildung und Forschung","grant_id":"01KI1009G","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"","title":null}],"total_grants":4,"fwci":4.2679,"citation_percentile":0.94346764,"influential_citations":0,"citation_trend":[{"year":2014,"count":3},{"year":2015,"count":3},{"year":2016,"count":10},{"year":2017,"count":5},{"year":2018,"count":4},{"year":2019,"count":4},{"year":2020,"count":4},{"year":2021,"count":7},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":8},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.jidonline.org/article/S0022202X15369608/pdf","host_type":"journal"},{"url":"http://www.jidonline.org/article/S0022202X15369608/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022202X15369608?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022202X15369608?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1038/jid.2014.176","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24717245","host_type":"repository"},{"url":"http://dx.doi.org/10.1038/jid.2014.176","host_type":""},{"url":"https://dx.doi.org/10.1038/jid.2014.176","host_type":""}],"fields_of_study":["Antimicrobial Peptides and Activities","Biochemical and Structural Characterization","Bacteriophages and microbial interactions","0301 basic medicine","0303 health sciences","03 medical and health sciences","Bacterial Proteins","Cathelicidins","Defensins","Disease Susceptibility","Epidermis","Humans","Immunity, Innate","Peptide Fragments","Phenotype","Ribonucleases","Staphylococcal Skin Infections","Staphylococcus aureus","beta-Defensins"],"mesh_terms":["Bacterial Proteins","Disease Susceptibility","Epidermis","Humans","Immunity, Innate","Peptide Fragments","Phenotype","Ribonucleases","Staphylococcal Skin Infections","Staphylococcus aureus","Defensins","beta-Defensins","Cathelicidins"],"keywords":["Staphylococcus aureus","Antimicrobial","Microbiology","Antimicrobial peptides","Staphylococcus","Biology","Staphylococcal infections","Bacteria","Genetics","beta-Defensins","Cell Biology","Dermatology","Biochemistry","Immunity, Innate","Peptide Fragments","Defensins","Phenotype","Ribonucleases","Bacterial Proteins","Cathelicidins","Humans","Staphylococcal Skin Infections","Disease Susceptibility","Epidermis","Molecular Biology"],"sdg_mappings":[{"sdg_number":2,"sdg_label":"2. 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