{"doi":"10.1038/jcbfm.2011.55","title":"Quantitation of Translocator Protein Binding in Human Brain with the Novel Radioligand [\n                    <sup>18</sup>\n                    F]-FEPPA and Positron Emission Tomography","abstract":"<jats:p>\n                    This article describes the kinetic modeling of [\n                    <jats:sup>18</jats:sup>\n                    F]-FEPPA binding to translocator protein 18 kDa in the human brain using high-resolution research tomograph (HRRT) positron emission tomography. Positron emission tomography scans were performed in 12 healthy volunteers for 180 minutes. A two-tissue compartment model (2-CM) provided, with no exception, better fits to the data than a one-tissue model. Estimates of total distribution volume ( V\n                    <jats:sub>T</jats:sub>\n                    ), specific distribution volume ( V\n                    <jats:sub>S</jats:sub>\n                    ), and binding potential ( BP\n                    <jats:sub>ND</jats:sub>\n                    ) demonstrated very good identifiability (based on coefficient of variation ( COV)) for all the regions of interest (ROIs) in the gray matter ( COV V\n                    <jats:sub>T</jats:sub>\n                    &lt; 7%, COV V\n                    <jats:sub>S</jats:sub>\n                    &lt; 8%, COV BP\n                    <jats:sub>ND</jats:sub>\n                    &lt; 11%). Reduction of the length of the scan to 2 hours is feasible as V\n                    <jats:sub>S</jats:sub>\n                    and V\n                    <jats:sub>T</jats:sub>\n                    showed only a small bias (6% and 7.5%, respectively). Monte Carlo simulations showed that, even under conditions of a 500% increase in specific binding, the identifiability of V\n                    <jats:sub>T</jats:sub>\n                    and V\n                    <jats:sub>S</jats:sub>\n                    was still very good with COV&lt;10%, across high-uptake ROIs. The excellent identifiability of V\n                    <jats:sub>T</jats:sub>\n                    values obtained from an unconstrained 2-CM with data from a 2-hour scan support the use of V\n                    <jats:sub>T</jats:sub>\n                    as an appropriate and feasible outcome measure for [\n                    <jats:sup>18</jats:sup>\n                    F]-FEPPA.\n                  </jats:p>","journal":"Journal of Cerebral Blood Flow &amp; Metabolism","year":2011,"id":614529,"datarank":0.7064295301968502,"base_score":4.709530201312334,"endowment":4.709530201312334,"self_citation_contribution":0.7064295301968502,"citation_network_contribution":0.0,"self_endowment_contribution":0.7064295301968502,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":110,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":4,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1583617,"name":"Alan A Wilson","orcid":null,"position":1,"is_corresponding":false},{"id":1583618,"name":"Peter M Bloomfield","orcid":null,"position":2,"is_corresponding":false},{"id":1583619,"name":"Irina Vitcu","orcid":null,"position":3,"is_corresponding":false},{"id":1583620,"name":"Jeffrey H Meyer","orcid":null,"position":4,"is_corresponding":false},{"id":345083,"name":"Sylvain Houle","orcid":"0000-0002-4231-6316","position":5,"is_corresponding":false},{"id":493654,"name":"Romina Mizrahi","orcid":"0000-0001-6667-7928","position":6,"is_corresponding":false},{"id":1583616,"name":"Pablo M Rusjan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Quantitation of Translocator Protein Binding in Human Brain with the Novel Radioligand [\n                    <sup>18</sup>\n                    F]-FEPPA and Positron Emission Tomography","abstract":"<jats:p>\n                    This article describes the kinetic modeling of [\n                    <jats:sup>18</jats:sup>\n                    F]-FEPPA binding to translocator protein 18 kDa in the human brain using high-resolution research tomograph (HRRT) positron emission tomography. Positron emission tomography scans were performed in 12 healthy volunteers for 180 minutes. A two-tissue compartment model (2-CM) provided, with no exception, better fits to the data than a one-tissue model. Estimates of total distribution volume ( V\n                    <jats:sub>T</jats:sub>\n                    ), specific distribution volume ( V\n                    <jats:sub>S</jats:sub>\n                    ), and binding potential ( BP\n                    <jats:sub>ND</jats:sub>\n                    ) demonstrated very good identifiability (based on coefficient of variation ( COV)) for all the regions of interest (ROIs) in the gray matter ( COV V\n                    <jats:sub>T</jats:sub>\n                    &lt; 7%, COV V\n                    <jats:sub>S</jats:sub>\n                    &lt; 8%, COV BP\n                    <jats:sub>ND</jats:sub>\n                    &lt; 11%). Reduction of the length of the scan to 2 hours is feasible as V\n                    <jats:sub>S</jats:sub>\n                    and V\n                    <jats:sub>T</jats:sub>\n                    showed only a small bias (6% and 7.5%, respectively). Monte Carlo simulations showed that, even under conditions of a 500% increase in specific binding, the identifiability of V\n                    <jats:sub>T</jats:sub>\n                    and V\n                    <jats:sub>S</jats:sub>\n                    was still very good with COV&lt;10%, across high-uptake ROIs. The excellent identifiability of V\n                    <jats:sub>T</jats:sub>\n                    values obtained from an unconstrained 2-CM with data from a 2-hour scan support the use of V\n                    <jats:sub>T</jats:sub>\n                    as an appropriate and feasible outcome measure for [\n                    <jats:sup>18</jats:sup>\n                    F]-FEPPA.\n                  </jats:p>","is_dataset_classified":null,"base_score":4.709530201312334,"endowment":4.709530201312334,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21522163","pmcid":"PMC3170950","openalex_id":"https://openalex.org/W2038892136","authors":[],"funders":[],"total_grants":0,"fwci":4.5056,"citation_percentile":0.94335655,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":7},{"year":2014,"count":9},{"year":2015,"count":8},{"year":2016,"count":10},{"year":2017,"count":15},{"year":2018,"count":11},{"year":2019,"count":4},{"year":2020,"count":12},{"year":2021,"count":6},{"year":2022,"count":9},{"year":2023,"count":6},{"year":2024,"count":3},{"year":2025,"count":6},{"year":2026,"count":1}],"oa_status":"bronze","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2011.55","host_type":"journal"},{"url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2011.55","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.1038/jcbfm.2011.55","host_type":"publisher"},{"url":"https://doi.org/10.1038/jcbfm.2011.55","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21522163","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3170950","host_type":"repository"}],"fields_of_study":["Medical Imaging Techniques and Applications","Radiopharmaceutical Chemistry and Applications","RNA Research and Splicing","Adult","Aged","Anilides","Brain","Female","Fluorine Radioisotopes","Humans","Male","Middle Aged","Positron-Emission Tomography","Protein Binding","Pyridines","Radiopharmaceuticals","Young Adult"],"mesh_terms":["Adult","Aged","Anilides","Brain","Female","Fluorine Radioisotopes","Humans","Male","Middle Aged","Protein Binding","Pyridines","Radiopharmaceuticals","Positron-Emission Tomography","Young Adult"],"keywords":["Translocator protein","Radioligand","Positron emission tomography","Brain positron emission tomography","Positron","Positron emission","Human brain","Physics","Nuclear magnetic resonance","Nuclear medicine","Chemistry","Medicine","Preclinical imaging","Nuclear physics","Neuroscience","Biology","Pathology","Biochemistry","Receptor","In vivo"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.13023330.v1","title":"Additional file 1 of TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.13023330","title":"Additional file 1 of TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14227913.v1","title":"Additional file 1 of GMP-compliant fully automated radiosynthesis of [18F]FEPPA for PET/MRI imaging of regional brain TSPO expression","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14227913","title":"Additional file 1 of GMP-compliant fully automated radiosynthesis of [18F]FEPPA for PET/MRI imaging of regional brain TSPO expression","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T14:07:49.548029Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}