{"doi":"10.1038/emm.2005.22","title":"Inositol 5'-phosphatase, SHIP1 interacts with phospholipase C-γ1 and modulates EGF-induced PLC activity","abstract":null,"journal":"Experimental & Molecular Medicine","year":2005,"id":609439,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1566423,"name":"Myung Jong Kim","orcid":null,"position":1,"is_corresponding":false},{"id":1566424,"name":"Sanghoon Ha","orcid":null,"position":2,"is_corresponding":false},{"id":1021540,"name":"Jong Bae Park","orcid":"0000-0003-0207-0697","position":3,"is_corresponding":false},{"id":918411,"name":"Sung Ho Ryu","orcid":"0000-0003-0913-3048","position":4,"is_corresponding":false},{"id":1566425,"name":"Pann-Ghill Suh","orcid":null,"position":5,"is_corresponding":false},{"id":634462,"name":"Minseok Song","orcid":"0000-0003-2932-284X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Inositol 5'-phosphatase, SHIP1 interacts with phospholipase C-γ1 and modulates EGF-induced PLC activity","abstract":"Phospholipase C-gamma1, containing two SH2 and one SH3 domains which participate in the interaction between signaling molecules, plays a significant role in the growth factor-induced signal transduction. However, the role of the SH domains in the growth factor-induced PLC-gamma1 regulation is unclear. By peptide-mass fingerprinting analysis, we have identified SHIP1 as the binding protein for the SH3 domain of PLC-gamma1. SHIP1 was co-immunoprecipitated with PLC-gamma1 and potentiated EGF-induced PLC-gamma1 activation. However, inositol 5'-phosphatase activity of SHIP1 was not required for the potentiation of EGF-induced PLC-gamma1 activation. Taken together, these results suggest that SHIP1 may function as an adaptor protein which can potentiate EGF-induced PLC-gamma1 activation without regards to its inositol 5'-phosphatase activity.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16000869","pmcid":null,"openalex_id":"https://openalex.org/W2161046622","authors":[],"funders":[],"total_grants":0,"fwci":0.4504,"citation_percentile":0.64205578,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2023,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.nature.com/articles/emm200522.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/emm200522.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/emm200522.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/emm200522","host_type":"publisher"},{"url":"https://doi.org/10.1038/emm.2005.22","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16000869","host_type":"repository"},{"url":"https://oasis.postech.ac.kr/handle/2014.oak/24483","host_type":"repository"}],"fields_of_study":["Liver physiology and pathology","Protein Kinase Regulation and GTPase Signaling","Pancreatic function and diabetes"],"mesh_terms":["Inositol Polyphosphate 5-Phosphatases","Amino Acid Sequence","Animals","Chlorocebus aethiops","Enzyme Activation","Epidermal Growth Factor","Molecular Sequence Data","Type C Phospholipases","Phosphoric Monoester Hydrolases","Protein Binding","Signal Transduction","Inositol 1,4,5-Trisphosphate","src Homology Domains","COS Cells","Immunoprecipitation","Adaptor Proteins, Signal Transducing","Phospholipase C gamma"],"keywords":["Inositol","Phospholipase C","Phosphatase","Chemistry","Cell biology","Gq alpha subunit","Phospholipase","Inositol phosphate","Internal medicine","Endocrinology","Biochemistry","Biology","Signal transduction","Enzyme","Receptor","Medicine","G protein"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T07:52:35.681540Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}