{"doi":"10.1038/cti.2017.49","title":"Progress of genome‐wide association studies of ankylosing spondylitis","abstract":"<jats:p>Ankylosing spondylitis (AS) is an immune‐mediated arthritis which primarily affects the spine and sacroiliac joints. Significant progress has been made in discovery of genetic associations with AS by genome‐wide association studies (GWAS) over past decade. These findings have uncovered novel pathways involved pathogenesis of the disease and have led to introduction of novel therapeutic treatments for AS. In this Review, we discuss the genetic variations associated with AS identified by GWAS, the major pathways revealed by these AS‐associated variations and critical cell types involved in AS development.</jats:p>","journal":"Clinical &amp; Translational Immunology","year":2017,"id":14491,"datarank":2.2663493474937355,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":1.6736627897065213,"self_endowment_contribution":0.5926865577872142,"citer_contribution":1.6736627897065213,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":48,"citers_with_citation_signal":39,"citers_with_endowment":39,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":114242,"name":"Matthew A Brown","orcid":null,"position":1,"is_corresponding":false},{"id":114241,"name":"Zhixiu Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29333268","pmcid":"PMC5750450","openalex_id":"https://openalex.org/W2771541573","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"}],"total_grants":1,"fwci":5.194,"citation_percentile":0.96070114,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":4},{"year":2019,"count":11},{"year":2020,"count":8},{"year":2021,"count":9},{"year":2022,"count":7},{"year":2023,"count":5},{"year":2024,"count":3},{"year":2025,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/cti.2017.49","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/cti.2017.49","host_type":"GOLD"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/cti.2017.49","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1038/cti.2017.49","host_type":"publisher"},{"url":"https://doi.org/10.1038/cti.2017.49","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29333268","host_type":"repository"},{"url":"http://purl.org/au-research/grants/nhmrc/1118005","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5750450","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5750450","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5750450?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1038/cti.2017.49","host_type":""},{"url":"https://api.library.uq.edu.au/view/UQ:708835","host_type":""},{"url":"https://dx.doi.org/10.1038/cti.2017.49","host_type":""},{"url":"https://doi.org/https://doi.org/10.1038/cti.2017.49","host_type":""}],"fields_of_study":["Spondyloarthritis Studies and Treatments","Systemic Lupus Erythematosus Research","Liver Diseases and Immunity","Medicine","Biology","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":[],"keywords":["Genome-wide association study","Ankylosing spondylitis","Genetic association","Spondylitis","Disease","Medicine","Computational biology","Biology","Bioinformatics","Genetics","Immunology","Single-nucleotide polymorphism","Gene","Genotype","Pathology","Skg Mice","2403 Immunology","Rheumatoid-Arthritis","610","T-Cells","Review","Peripheral-Blood","2900 Nursing","Han Chinese Population","Hla-B27 Homozygosity","2723 Immunology and Allergy","Inflammatory-Bowel-Disease","Axial Spondyloarthritis","Intestinal Inflammation"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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