{"doi":"10.1038/cmi.2012.60","title":"Regulatory B cells in autoimmune diseases","abstract":null,"journal":"Cellular & Molecular Immunology","year":2013,"id":680093,"datarank":0.7909499337845621,"base_score":5.272999558563747,"endowment":5.272999558563747,"self_citation_contribution":0.7909499337845621,"citation_network_contribution":0.0,"self_endowment_contribution":0.7909499337845621,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":194,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1776945,"name":"Ke Rui","orcid":null,"position":1,"is_corresponding":false},{"id":35912,"name":"Shengjun Wang","orcid":"0000-0001-6584-1183","position":2,"is_corresponding":false},{"id":1776946,"name":"Liwei Lu","orcid":null,"position":3,"is_corresponding":false},{"id":5471,"name":"Min Yang","orcid":"0000-0002-9034-3175","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Regulatory B cells in autoimmune diseases","abstract":"B cells are generally considered to be positive regulators of the immune response because of their capability to produce antibodies, including autoantibodies. The production of antibodies facilitates optimal CD4(+) T-cell activation because B cells serve as antigen-presenting cells and exert other modulatory functions in immune responses. However, certain B cells can also negatively regulate the immune response by producing regulatory cytokines and directly interacting with pathogenic T cells via cell-to-cell contact. These types of B cells are defined as regulatory B (Breg) cells. The regulatory function of Breg cells has been demonstrated in mouse models of inflammation, cancer, transplantation, and particularly in autoimmunity. In this review, we focus on the recent advances that lead to the understanding of the development and function of Breg cells and the implications of B cells in human autoimmune diseases.","is_dataset_classified":null,"base_score":5.272999558563747,"endowment":5.272999558563747,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23292280","pmcid":"PMC4003045","openalex_id":"https://openalex.org/W2171593203","authors":[],"funders":[],"total_grants":0,"fwci":9.036,"citation_percentile":0.98459444,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":6},{"year":2014,"count":19},{"year":2015,"count":20},{"year":2016,"count":22},{"year":2017,"count":20},{"year":2018,"count":17},{"year":2019,"count":15},{"year":2020,"count":13},{"year":2021,"count":20},{"year":2022,"count":11},{"year":2023,"count":11},{"year":2024,"count":6},{"year":2025,"count":10},{"year":2026,"count":2}],"oa_status":"bronze","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://www.nature.com/articles/cmi201260.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/cmi201260.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/cmi201260","host_type":"publisher"},{"url":"https://doi.org/10.1038/cmi.2012.60","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23292280","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC4003045","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4003045","host_type":"repository"},{"url":"http://hdl.handle.net/10722/186445","host_type":"repository"}],"fields_of_study":["T-cell and B-cell Immunology","Immune Cell Function and Interaction","Immunotherapy and Immune Responses","Animals","Autoimmune Diseases","B-Lymphocyte Subsets","Disease Models, Animal","Humans","Immunophenotyping","Inflammation","Interleukin-10","Mice","Transforming Growth Factor beta"],"mesh_terms":["Animals","Autoimmune Diseases","Disease Models, Animal","Humans","Inflammation","Immunophenotyping","B-Lymphocyte Subsets","Transforming Growth Factor beta","Interleukin-10","Mice"],"keywords":["Regulatory B cells","Autoimmunity","Immune system","Immunology","Biology","Autoantibody","B cell","Antibody","Cell biology","Interleukin 10"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T14:21:56.944574Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}