{"doi":"10.1038/clpt.2009.103","title":"Systematic Evaluation of Drug–Disease Relationships to Identify Leads for Novel Drug Uses","abstract":"Drug repositioning refers to the discovery of alternative uses for drugs--uses that are different from that for which the drugs were originally intended. One challenge in this effort lies in choosing the indication for which a drug of interest could be prospectively tested. We systematically evaluated a drug treatment-based view of diseases in order to address this challenge. Suggestions for novel drug uses were generated using a \"guilt by association\" approach. When compared with a control group of drug uses, the suggested novel drug uses generated by this approach were significantly enriched with respect to previous and ongoing clinical trials.","journal":"Clinical Pharmacology & Therapeutics","year":2009,"id":5280,"datarank":0.8419692159582107,"base_score":5.6131281063880705,"endowment":5.6131281063880705,"self_citation_contribution":0.8419692159582107,"citation_network_contribution":0.0,"self_endowment_contribution":0.8419692159582107,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":273,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0512,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2009-07-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":35349,"name":"Annie Chiang","orcid":"0000-0003-0188-1586","position":2,"is_corresponding":false},{"id":51,"name":"Atul Janardhan Butte","orcid":"0000-0002-7433-2740","position":3,"is_corresponding":false},{"id":35347,"name":"Annie P Chiang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}