{"doi":"10.1038/bcj.2014.12","title":"Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia","abstract":null,"journal":"Blood Cancer Journal","year":2014,"id":592967,"datarank":2.6292864735165593,"base_score":4.290459441148391,"endowment":4.290459441148391,"self_citation_contribution":0.6435689161722588,"citation_network_contribution":1.9857175573443007,"self_endowment_contribution":0.6435689161722588,"citer_contribution":1.9857175573443007,"corpus_percentile":null,"corpus_rank":null,"citation_count":72,"citer_count":64,"citers_with_citation_signal":56,"citers_with_endowment":56,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1517488,"name":"Y Erbilgin","orcid":null,"position":1,"is_corresponding":false},{"id":1517489,"name":"S Firtina","orcid":null,"position":2,"is_corresponding":false},{"id":1517490,"name":"T Celkan","orcid":null,"position":3,"is_corresponding":false},{"id":1517491,"name":"Z Karakas","orcid":null,"position":4,"is_corresponding":false},{"id":1517492,"name":"G Aydogan","orcid":null,"position":5,"is_corresponding":false},{"id":1517493,"name":"E Turkkan","orcid":null,"position":6,"is_corresponding":false},{"id":1517494,"name":"Y Yildirmak","orcid":null,"position":7,"is_corresponding":false},{"id":1517495,"name":"C Timur","orcid":null,"position":8,"is_corresponding":false},{"id":1517496,"name":"E Zengin","orcid":null,"position":9,"is_corresponding":false},{"id":1517497,"name":"J J M van Dongen","orcid":null,"position":10,"is_corresponding":false},{"id":1517498,"name":"F J T Staal","orcid":null,"position":11,"is_corresponding":false},{"id":1517499,"name":"U Ozbek","orcid":null,"position":12,"is_corresponding":false},{"id":1517500,"name":"M Sayitoglu","orcid":null,"position":13,"is_corresponding":false},{"id":1517487,"name":"O H Ng","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia","abstract":"WNT signaling has been implicated in the regulation of hematopoietic stem cells and plays an important role during T-cell development in thymus. Here we investigated WNT pathway activation in childhood T-cell acute lymphoblastic leukemia (T-ALL) patients. To evaluate the potential role of WNT signaling in T-cell leukomogenesis, we performed expression analysis of key components of WNT pathway. More than 85% of the childhood T-ALL patients showed upregulated β-catenin expression at the protein level compared with normal human thymocytes. The impact of this upregulation was reflected in high expression of known target genes (AXIN2, c-MYC, TCF1 and LEF). Especially AXIN2, the universal target gene of WNT pathway, was upregulated at both mRNA and protein levels in ∼40% of the patients. When β-CATENIN gene was silenced by small interfering RNA, the cancer cells showed higher rates of apoptosis. These results demonstrate that abnormal WNT signaling activation occurs in a significant fraction of human T-ALL cases independent of known T-ALL risk factors. We conclude that deregulated WNT signaling is a novel oncogenic event in childhood T-ALL.","is_dataset_classified":null,"base_score":4.290459441148391,"endowment":4.290459441148391,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24632884","pmcid":"PMC3972698","openalex_id":"https://openalex.org/W2119753435","authors":[],"funders":[{"funder_name":"Worldwide Cancer Research","grant_id":"09-36","title":null},{"funder_name":"Worldwide Cancer Research","grant_id":"07-0049","title":null},{"funder_name":"Türkiye Bilimsel ve Teknolojik Araştırma Kurumu","grant_id":"106S112","title":"Akut Lösemilerde WNT Sinyal İleti Yolunun Araştırılması ve Tedavide Fayda Sağlayacak Hedef Moleküllerin Belirlenmesi"},{"funder_name":"Türkiye Bilimsel ve Teknolojik Araştırma Kurumu","grant_id":"109S395","title":"T Hücreli Akut Lenfoblastik Lösemide Genom Boyu Anlatim Analizleri"}],"total_grants":4,"fwci":2.5995,"citation_percentile":0.90464961,"influential_citations":0,"citation_trend":[{"year":2015,"count":3},{"year":2016,"count":8},{"year":2017,"count":9},{"year":2018,"count":4},{"year":2019,"count":4},{"year":2020,"count":14},{"year":2021,"count":9},{"year":2022,"count":5},{"year":2023,"count":6},{"year":2024,"count":1},{"year":2025,"count":8},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.nature.com/articles/bcj201412.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/bcj201412.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/bcj201412.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/bcj201412","host_type":"publisher"},{"url":"https://doi.org/10.1038/bcj.2014.12","host_type":"journal"},{"url":"http://www.osti.gov/scitech/biblio/4257897-constitution-systems-rare-earths-yttrium-iron-cobalt-nickel","host_type":"repository"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24632884","host_type":"repository"},{"url":"https://avesis.kocaeli.edu.tr/publication/details/0d11d0e7-8116-485f-b637-b6d0dde4c6d0/oai","host_type":"repository"},{"url":"https://pure.eur.nl/en/publications/8582374f-9741-41f2-9eb2-9de72b5fcb54","host_type":"repository"},{"url":"http://hdl.handle.net/1765/58242","host_type":"repository"},{"url":"http://hdl.handle.net/1887/104527","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3972698","host_type":"repository"},{"url":"http://repub.eur.nl/pub/58242","host_type":"repository"},{"url":"https://hdl.handle.net/1887/104527","host_type":"repository"},{"url":"https://avesis.kocaeli.edu.tr/publication/details/0d11d0e7-8116-485f-b637-b6d0dde4c6d0/oai/document.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3972698","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3972698?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1038/bcj.2014.12","host_type":""},{"url":"https://dx.doi.org/10.1038/bcj.2014.12","host_type":""},{"url":"https://hdl.handle.net/20.500.12831/40108","host_type":""},{"url":"https://aperta.ulakbim.gov.tr/record/111898","host_type":""}],"fields_of_study":["Cancer-related gene regulation","T-cell and Retrovirus Studies","Acute Lymphoblastic Leukemia research","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Wnt signaling pathway","AXIN2","Downregulation and upregulation","Biology","Cancer research","Signal transduction","Haematopoiesis","Stem cell","Leukemia","Immunology","Cell biology","Gene","Genetics","EMC MM-02-72-03","Beta-Catenin Mutation","Thymocytes","Transcription Factor","Carcinoma","Activation","Expression","Transformation","SDG 3 - Good Health and Well-being","Original Article","Pathways"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T16:28:15.156107Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}