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Cellular senescence can be induced in response to oncogenic activation and acts as a barrier to tumorigenesis. Moreover, tumor cells can undergo senescence when exposed to chemotherapeutic agents. In addition to suppressing tumorigenesis, senescent cells remain metabolically active and may contribute to tumor formation and to therapy resistance. In the current review, we discuss the molecular regulation of cellular senescence, the potential implications of senescence in human cancers, and the possibility of exploiting cellular senescence for the treatment of cancers.","is_dataset_classified":null,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21909124","pmcid":"PMC3760423","openalex_id":"https://openalex.org/W2085757963","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"R01 CA135038","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R01CA135038-01A2","title":"Autophagy in Brain Tumor"}],"total_grants":2,"fwci":1.4453,"citation_percentile":0.80476423,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":2},{"year":2014,"count":3},{"year":2015,"count":2},{"year":2017,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":5},{"year":2022,"count":1},{"year":2024,"count":2},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"bronze","license":"Springer TDM","oa_locations":[{"url":"https://www.nature.com/articles/aps2011108.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/aps2011108.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/aps2011108","host_type":"publisher"},{"url":"https://doi.org/10.1038/aps.2011.108","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21909124","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3760423","host_type":"repository"},{"url":"https://dx.doi.org/10.1038/aps.2011.108","host_type":""}],"fields_of_study":["Telomeres, Telomerase, and Senescence","Epigenetics and DNA Methylation","Advanced biosensing and bioanalysis techniques","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Antineoplastic Agents","Cellular Senescence","Humans","MicroRNAs","Neoplasms","Oncogenes","Signal Transduction","Telomerase","Telomere"],"mesh_terms":["Animals","Antineoplastic Agents","Humans","Neoplasms","Oncogenes","Signal Transduction","Telomere","Cellular Senescence","Telomerase","MicroRNAs"],"keywords":["Senescence","Carcinogenesis","Cellular senescence","Endogeny","Biology","Cancer","Cell biology","Cancer research","Genetics","Biochemistry","Phenotype","Gene","Antineoplastic Agents","Oncogenes","Telomere","MicroRNAs","Neoplasms","Animals","Humans","Telomerase","Signal Transduction"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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