{"doi":"10.1038/ajh.2011.65","title":"Methionine-Induced Homocysteinemia Impairs Endothelial Function in Hypertensives: The Role of Asymmetrical Dimethylarginine and Antioxidant Vitamins","abstract":null,"journal":"American Journal of Hypertension","year":2011,"id":663257,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1731556,"name":"G. Bouras","orcid":null,"position":1,"is_corresponding":false},{"id":1731559,"name":"C. Antoniades","orcid":null,"position":2,"is_corresponding":false},{"id":1731561,"name":"K. Marinou","orcid":null,"position":3,"is_corresponding":false},{"id":1731563,"name":"N. Papageorgiou","orcid":null,"position":4,"is_corresponding":false},{"id":1731565,"name":"A. Miliou","orcid":null,"position":5,"is_corresponding":false},{"id":1731567,"name":"G. Hatzis","orcid":null,"position":6,"is_corresponding":false},{"id":1731569,"name":"E. Stefanadi","orcid":null,"position":7,"is_corresponding":false},{"id":1505391,"name":"C. Tsioufis","orcid":null,"position":8,"is_corresponding":false},{"id":1731570,"name":"C. Stefanadis","orcid":null,"position":9,"is_corresponding":false},{"id":1505392,"name":"D. Tousoulis","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Methionine-Induced Homocysteinemia Impairs Endothelial Function in Hypertensives: The Role of Asymmetrical Dimethylarginine and Antioxidant Vitamins","abstract":"BACKGROUND: Nitric oxide synthase (NOS) inhibitor asymmetrical dimethylarginine (ADMA) is synthesized by the methylation of arginine as part of the methionine/homocysteine cycle. However, the mechanisms regulating ADMA synthesis in hypertension are unclear. METHODS: We investigated the role of ADMA and antioxidants in endothelial dysfunction during methionine-induced homocysteinemia in hypertensives. Thirty-nine hypertensives and forty-nine normotensive controls underwent methionine loading (100 mg methionine/kg BW), after being randomized to receive vitamin C (2 g) and E (800 IU) or placebo. Endothelium-dependent dilation (EDD) was evaluated by plethysmography (baseline and 4-h post-methionine loading (4-h PML)). RESULTS: Hypertensives had higher homocysteine at baseline (P < 0.001) and 4-h PML (P < 0.05), whereas methionine increased homocysteine in all groups. EDD was decreased in both vitamins and placebo groups in controls (P < 0.01 for both) and vitamins- and placebo-treated hypertensives (P < 0.05 and P < 0.01, respectively). In controls, ADMA was increased in both vitamin- and placebo groups (P < 0.01 for both) at 4-h PML. Hypertensives had higher ADMA at baseline (P < 0.01 vs. normotensive) and remained unchanged at 4-h PML (P = NS in placebo and vitamins treated). CONCLUSIONS: ADMA is elevated in hypertensives but remains unchanged after methionine loading, suggesting that ADMA plays an important role in endothelial dysfunction in hypertensives, but it is not responsible for homocysteine-induced endothelial dysfunction in these patients.","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21490695","pmcid":null,"openalex_id":"https://openalex.org/W2093043427","authors":[],"funders":[],"total_grants":0,"fwci":0.8258,"citation_percentile":0.73640035,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2014,"count":1},{"year":2015,"count":2},{"year":2017,"count":3},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://academic.oup.com/ajh/article-pdf/24/8/936/8662693/24_8_936.pdf","host_type":"journal"},{"url":"https://academic.oup.com/ajh/article-pdf/24/8/936/8662693/24_8_936.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/ajh/article-pdf/24/8/936/8662693/24_8_936.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1038/ajh.2011.65","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21490695","host_type":"repository"},{"url":"https://ora.ox.ac.uk/objects/uuid:df39c3ac-9d17-4e60-bb4a-e7917921a03a","host_type":"repository"}],"fields_of_study":["Folate and B Vitamins Research","Nitric Oxide and Endothelin Effects","Cancer Research and Treatments"],"mesh_terms":["Adult","Antioxidants","Arginine","Ascorbic Acid","Endothelium, Vascular","Female","Homocysteine","Humans","Hypertension","Male","Methionine","Middle Aged","Vasodilation","Vitamin E","Hyperhomocysteinemia"],"keywords":["Asymmetric dimethylarginine","Endothelial dysfunction","Homocysteine","Internal medicine","Endocrinology","Methionine","Medicine","Placebo","Endothelium","Nitric oxide","Hyperhomocysteinemia","Arginine","Biochemistry","Chemistry","Amino acid"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T20:42:24.166755Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}