{"doi":"10.1038/78062","title":"Mesp2 initiates somite segmentation through the Notch signalling pathway","abstract":null,"journal":"Nature Genetics","year":2000,"id":666724,"datarank":0.7977179990766325,"base_score":5.318119993844216,"endowment":5.318119993844216,"self_citation_contribution":0.7977179990766325,"citation_network_contribution":0.0,"self_endowment_contribution":0.7977179990766325,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":203,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1741137,"name":"Ken-ichi Koizumi","orcid":null,"position":1,"is_corresponding":false},{"id":1741138,"name":"Atsuya Takagi","orcid":null,"position":2,"is_corresponding":false},{"id":1741139,"name":"Satoshi Kitajima","orcid":null,"position":3,"is_corresponding":false},{"id":1741140,"name":"Tohru Inoue","orcid":null,"position":4,"is_corresponding":false},{"id":77684,"name":"Haruhiko Koseki","orcid":"0000-0001-8424-5854","position":5,"is_corresponding":false},{"id":201291,"name":"Yumiko Saga","orcid":null,"position":6,"is_corresponding":false},{"id":1445592,"name":"Yu Takahashi","orcid":"0000-0002-3066-9501","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mesp2 initiates somite segmentation through the Notch signalling pathway","abstract":"The Notch-signalling pathway is important in establishing metameric pattern during somitogenesis. In mice, the lack of either of two molecules involved in the Notch-signalling pathway, Mesp2 or presenilin-1 (Ps1), results in contrasting phenotypes: caudalized versus rostralized vertebra. Here we adopt a genetic approach to analyse the molecular mechanism underlying the establishment of rostro-caudal polarity in somites. By focusing on the fact that expression of a Notch ligand, Dll1, is important for prefiguring somite identity, we found that Mesp2 initiates establishment of rostro-caudal polarity by controlling two Notch-signalling pathways. Initially, Mesp2 activates a Ps1-independent Notch-signalling cascade to suppress Dll1 expression and specify the rostral half of the somite. Ps1-mediated Notch-signalling is required to induce Dll1 expression in the caudal half of the somite. Therefore, Mesp2- and Ps1-dependent activation of Notch-signalling pathways might differentially regulate Dll1 expression, resulting in the establishment of the rostro-caudal polarity of somites.","is_dataset_classified":null,"base_score":5.318119993844216,"endowment":5.318119993844216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10932180","pmcid":null,"openalex_id":"https://openalex.org/W1561855402","authors":[],"funders":[],"total_grants":0,"fwci":3.5534,"citation_percentile":0.93217616,"influential_citations":0,"citation_trend":[{"year":2012,"count":12},{"year":2013,"count":5},{"year":2014,"count":4},{"year":2015,"count":5},{"year":2016,"count":10},{"year":2017,"count":2},{"year":2018,"count":6},{"year":2019,"count":2},{"year":2020,"count":6},{"year":2021,"count":3},{"year":2022,"count":8},{"year":2023,"count":3},{"year":2024,"count":5},{"year":2025,"count":4}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://www.nature.com/articles/ng0800_390.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/ng0800_390","host_type":"publisher"},{"url":"https://doi.org/10.1038/78062","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10932180","host_type":"repository"}],"fields_of_study":["Developmental Biology and Gene Regulation","dental development and anomalies","Congenital heart defects research","Animals","Basic Helix-Loop-Helix Proteins","Body Patterning","Embryo, Mammalian","Female","Gene Expression Regulation, Developmental","Humans","Ligands","Male","Membrane Proteins","Mice","Mice, Inbred C57BL","Mice, Inbred CBA","Mice, Transgenic","Mutation","Presenilin-1","Receptors, Notch","Signal Transduction","Somites","Transcription Factors"],"mesh_terms":["Animals","Embryo, Mammalian","Female","Humans","Ligands","Male","Membrane Proteins","Mice, Inbred CBA","Mice, Inbred C57BL","Mice, Transgenic","Mutation","Transcription Factors","Signal Transduction","Gene Expression Regulation, Developmental","Somites","Body Patterning","Mice","Basic Helix-Loop-Helix Proteins","Basic Helix-Loop-Helix Transcription Factors","Receptors, Notch","Presenilin-1"],"keywords":["Somitogenesis","Somite","Notch signaling pathway","Biology","Cell biology","Notch proteins","Signalling","Hes3 signaling axis","Polarity (international relations)","Phenotype","Signal transduction","Genetics","Gene","Embryo","Embryogenesis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T15:19:09.461200Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}