{"doi":"10.1038/414813a","title":"Biochemistry and molecular cell biology of diabetic complications","abstract":"Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.","journal":"Nature","year":2001,"id":4297,"datarank":12.143007481128397,"base_score":9.103756886573398,"endowment":9.103756886573398,"self_citation_contribution":1.36556353298601,"citation_network_contribution":10.777443948142386,"self_endowment_contribution":1.36556353298601,"citer_contribution":10.777443948142386,"corpus_percentile":89.5,"corpus_rank":1382,"citation_count":8988,"citer_count":191,"citers_with_citation_signal":191,"citers_with_endowment":191,"datacite_reuse_total":0,"is_dataset":false,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2001-12-13","authors":[{"id":44575,"name":"Michael Brownlee","orcid":null,"position":0,"is_corresponding":true}],"reference_count":100,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}