{"doi":"10.1038/307643a0","title":"A dynorphinergic pathway of Leu-enkephalin production in rat substantia nigra","abstract":null,"journal":"Nature","year":1984,"id":636918,"datarank":0.7712495334753992,"base_score":5.14166355650266,"endowment":5.14166355650266,"self_citation_contribution":0.7712495334753992,"citation_network_contribution":0.0,"self_endowment_contribution":0.7712495334753992,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":170,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":59266,"name":"Miklós Palkovits","orcid":"0000-0003-0578-0387","position":1,"is_corresponding":false},{"id":1653500,"name":"Eckward Weber","orcid":null,"position":2,"is_corresponding":false},{"id":344056,"name":"Éva Mezey","orcid":"0000-0002-5907-4691","position":3,"is_corresponding":false},{"id":119534,"name":"Michael J. Brownstein","orcid":null,"position":4,"is_corresponding":false},{"id":119535,"name":"Nadav Zamir","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A dynorphinergic pathway of Leu-enkephalin production in rat substantia nigra","abstract":"The amino acid sequence of the opioid peptide Leu-enkephalin is found within several larger peptides, which are generated from the precursors proenkephalin and prodynorphin. Proenkephalin contains four copies of the sequence of Met-enkephalin, a single copy of the sequence of Leu-enkephalin and one copy each of two extended Met-enkephalin sequences. Proenkephalin contains three peptides--alpha-neo-endorphin, dynorphin A and dynorphin B--the N-terminal sequences of which are identical to that of Leu-enkephalin. There is good evidence that the large amounts of Leu-enkephalin found in the adrenal medulla are generated from the precursor proenkephalin, but as yet prodynorphin has not been shown to be processed to yield Leu-enkephalin. We show here that the relatively high levels of Leu-enkephalin found in the rat substantia nigra are supplied by striatonigral axons and generated from the precursor prodynorphin.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6546413","pmcid":null,"openalex_id":"https://openalex.org/W6546413","authors":[],"funders":[],"total_grants":0,"fwci":0.6601,"citation_percentile":0.75818996,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://www.nature.com/articles/307643a0","host_type":"publisher"},{"url":"http://www.nature.com/articles/307643a0.pdf","host_type":"publisher"},{"url":"https://dialnet.unirioja.es/servlet/articulo?codigo=1023936","host_type":"journal"}],"fields_of_study":["Nursing care and research","Nursing Diagnosis and Documentation"],"mesh_terms":["Substantia Nigra","Caudate Nucleus","Animals","Rats","Enkephalins","Enkephalin, Leucine","Protein Precursors"],"keywords":["Humanities","Cartography","Geography","Philosophy"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T17:57:56.002401Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}