{"doi":"10.1037/rep0000626","title":"Long COVID brain fog treatment: An early-phase randomized controlled trial of constraint-induced cognitive therapy signals go.","abstract":"PURPOSE: Long COVID brain fog is often disabling. Yet, no empirically supported treatments exist. This study's objectives were to evaluate the feasibility and efficacy, provisionally, of a new rehabilitation approach, Constraint-Induced Cognitive Therapy (CICT), for post-COVID-19 cognitive sequelae. DESIGN: Sixteen community residents ≥3 months post-COVID-19 infection with mild cognitive impairment and dysfunction in instrumental activities of daily living (IADL) were enrolled. Participants were randomized to Immediate-CICT or treatment as usual (TAU) with crossover to CICT. CICT combined behavior change techniques modified from Constraint-Induced Movement Therapy with Speed of Processing Training, a computerized cognitive training program. CICT was deemed feasible if (a) ≥ 80% of participants were adherent, (b) the same found treatment highly satisfying and at most moderately difficult, and (c) < 2 study-related, serious adverse events occurred. The primary outcome was IADL performance in daily life (Canadian Occupational Performance Measure). Employment status and brain fog (Mental Clutter Scale) were also assessed. RESULTS: = .048. CONCLUSION: Those who received CICT adhered to the protocol and were highly satisfied with their outcomes. The findings warrant a large-scale randomized controlled trial with an active-comparison group. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","journal":"Rehabilitation Psychology","year":2025,"id":514710,"datarank":0.3167854469831817,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.004869215731206227,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.004869215731206227,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":7,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9624,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT04644172"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1331150,"name":"Edward Taub","orcid":"0000-0002-9586-2396","position":1,"is_corresponding":false},{"id":931124,"name":"Karlene Ball","orcid":"0000-0003-1811-9870","position":2,"is_corresponding":false},{"id":1331516,"name":"Brandon Mitchell","orcid":null,"position":3,"is_corresponding":false},{"id":1194226,"name":"Jason A. Blake","orcid":"0000-0002-4575-2420","position":4,"is_corresponding":false},{"id":1331517,"name":"Staci McKay","orcid":null,"position":5,"is_corresponding":false},{"id":1331518,"name":"Fedora Biney","orcid":null,"position":6,"is_corresponding":false},{"id":1331151,"name":"Olesya Iosipchuk","orcid":"0000-0002-4544-6298","position":7,"is_corresponding":false},{"id":1331519,"name":"Piper Hempfling","orcid":null,"position":8,"is_corresponding":false},{"id":1331520,"name":"Elise Harris","orcid":null,"position":9,"is_corresponding":false},{"id":1331152,"name":"Anne E. Dickerson","orcid":"0000-0002-3665-0799","position":10,"is_corresponding":false},{"id":1331521,"name":"Kristine Lokken","orcid":null,"position":11,"is_corresponding":false},{"id":1194669,"name":"Amy J. Knight","orcid":null,"position":12,"is_corresponding":false},{"id":1302505,"name":"Victor W. Mark","orcid":"0000-0002-9468-7952","position":13,"is_corresponding":false},{"id":1331153,"name":"Shruti Agnihotri","orcid":"0000-0002-2461-0255","position":14,"is_corresponding":false},{"id":270886,"name":"Gary Cutter","orcid":"0000-0002-8455-980X","position":15,"is_corresponding":false},{"id":1331149,"name":"Gitendra Uswatte","orcid":"0000-0003-4507-7098","position":0,"is_corresponding":true}],"reference_count":1,"raw_metadata":null,"created_at":"2026-07-19T02:48:34.431522Z","pmid":"40310209","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}