{"doi":"10.1037/abn0000701","title":"Adolescent cannabis use and adult psychoticism: A longitudinal co-twin control analysis using data from two cohorts.","abstract":"-5 Psychoticism scale) in adulthood. Twins also provided molecular genetic data, which were used to estimate polygenic risk of schizophrenia. Both cumulative adolescent cannabis use and use disorder were associated with higher Psychoticism scores in adulthood. However, we found no evidence of an effect of cannabis on Psychoticism or any of its facets in co-twin control models that compared the greater-cannabis-using twin to the lesser-using co-twin. We also observed no evidence of a differential effect of cannabis on Psychoticism by polygenic risk of schizophrenia. Although cannabis use and disorder are consistently associated with increased risk of psychosis, the present results suggest this association is likely attributable to familial confounds rather than a causal effect of cannabis exposure. Efforts to reduce the prevalence and burden of psychotic illnesses thus may benefit from greater focus on other therapeutic targets. (PsycInfo Database Record (c) 2021 APA, all rights reserved).","journal":"Journal of Abnormal Psychology","year":2021,"id":192319,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9438,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":14658,"name":"Seon-Kyeong Jang","orcid":"0000-0002-8533-6894","position":1,"is_corresponding":false},{"id":14729,"name":"Scott Vrieze","orcid":"0000-0003-3861-7930","position":2,"is_corresponding":false},{"id":230724,"name":"William G. Iacono","orcid":"0000-0002-3194-3090","position":3,"is_corresponding":false},{"id":14699,"name":"Matt McGue","orcid":"0000-0002-5580-1433","position":4,"is_corresponding":false},{"id":377315,"name":"Sylia Wilson","orcid":"0000-0003-0144-524X","position":5,"is_corresponding":false},{"id":656748,"name":"Jonathan D. Schaefer","orcid":"0000-0003-4112-9268","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-18T23:49:39.281850Z","pmid":"34553951","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}