{"doi":"10.1023/a:1025863029529","title":"Role of cyclooxygenase-2 in colorectal cancer","abstract":null,"journal":"Cancer and Metastasis Reviews","year":2004,"id":635319,"datarank":0.793995723708674,"base_score":5.293304824724492,"endowment":5.293304824724492,"self_citation_contribution":0.793995723708674,"citation_network_contribution":0.0,"self_endowment_contribution":0.793995723708674,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":198,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":461076,"name":"Sharlene Gill","orcid":"0000-0003-3306-3617","position":1,"is_corresponding":false},{"id":542687,"name":"Frank A. Sinicrope","orcid":"0000-0002-2907-1000","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Role of cyclooxygenase-2 in colorectal cancer","abstract":"Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. Recently, a causal link for COX-2 in epithelial tumorigenesis was shown in genetically-manipulated animal models of colon and breast carcinoma. Data indicate that COX-2 is involved in the regulation of apoptosis, angiogenesis, and tumor cell invasiveness, which appear to contribute to its effects on tumorigenesis. Multiple studies have shown that nonselective COX and selective COX-2 inhibitors effectively prevent experimental colon cancer. Furthermore, sulindac and the selective COX-2 inhibitor celecoxib were shown to regress colorectal polyps in patients with familial adenomatous polyposis. Although the exact anti-tumor mechanisms of these agents await further study, data indicate that both COX-dependent and COX-independent mechanisms may be important. In this review, the association between COX-2 and colorectal tumorigenesis and potential mechanisms of this effect are discussed. Additionally, evidence supporting the role of NSAIDs and selective COX-2 inhibitors for the prevention and treatment of human colorectal cancer is reviewed.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15000150","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1023/A:1025863029529.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1023/A:1025863029529/fulltext.html","host_type":"publisher"}],"fields_of_study":["Anti-Inflammatory Agents, Non-Steroidal","Apoptosis","Colorectal Neoplasms","Cyclooxygenase 2","Humans","Isoenzymes","Membrane Proteins","Models, Biological","Neoplasm Invasiveness","Neoplasms","Prostaglandin-Endoperoxide Synthases","Prostaglandins"],"mesh_terms":["Humans","Neoplasms","Colorectal Neoplasms","Neoplasm Invasiveness","Isoenzymes","Prostaglandins","Membrane Proteins","Anti-Inflammatory Agents, Non-Steroidal","Apoptosis","Models, Biological","Prostaglandin-Endoperoxide Synthases","Cyclooxygenase 2"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T14:56:23.661581Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}