{"doi":"10.1023/a:1015539109209","title":"Tetrapyrrole regulation of nuclear gene expression","abstract":null,"journal":"Photosynthesis Research","year":2002,"id":641222,"datarank":0.5375278407684165,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.0,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1666988,"name":"Michael P. Peterson","orcid":null,"position":1,"is_corresponding":false},{"id":495239,"name":"Judy A. Brusslan","orcid":"0000-0002-6744-3696","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Tetrapyrrole regulation of nuclear gene expression","abstract":"Tetrapyrroles are the structural backbone of chlorophyll and heme, and are essential for primary photochemistry, light harvesting, and electron transport. The biochemistry of their synthesis has been studied extensively, and it has been suggested that some of the tetrapyrrole biochemical intermediates can affect nuclear gene expression. In this review, tetrapyrrole biosynthesis, which occurs in the chloroplast, and its regulation will be covered. An analysis of the intracellular location of tetrapyrrole intermediates will also be included. The focus will be on tetrapyrrole intermediates that have been suggested to affect gene expression. These include Mg-protoporphyrin IX and Mg-protoporphyrin IX monomethyl ester. Recent evidence also suggests a specific signaling role for the H subunit of Mg-chelatase, an enzyme that catalyzes the insertion of Mg into the tetrapyrrole ring. Since gene expression studies have been done in plants and green algae, our discussion will be limited to these organisms.","is_dataset_classified":null,"base_score":3.58351893845611,"endowment":3.58351893845611,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16228131","pmcid":null,"openalex_id":"https://openalex.org/W1594924274","authors":[],"funders":[{"funder_name":"National Science Foundation","grant_id":"0084274","title":"RUI: Molecular Genetic Analysis of Chlorophyll b Synthesis in Arabidopsis"}],"total_grants":1,"fwci":0.7657,"citation_percentile":0.68008034,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"closed","license":"Springer Nature TDM","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1023/A:1015539109209.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1023/A:1015539109209/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1023/a:1015539109209","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16228131","host_type":"repository"},{"url":"https://dx.doi.org/10.1023/a:1015539109209","host_type":""}],"fields_of_study":["Photosynthetic Processes and Mechanisms","Porphyrin Metabolism and Disorders","Plant Stress Responses and Tolerance","0301 basic medicine","0106 biological sciences","03 medical and health sciences","01 natural sciences"],"mesh_terms":[],"keywords":["Tetrapyrrole","Heme","Protoporphyrin IX","Ferrochelatase","Biochemistry","Gene expression","Nuclear gene","Chemistry","Chloroplast","Protoporphyrin","Gene","Cell biology","Biology","Enzyme","Genome","Photodynamic therapy","Porphyrin"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T16:41:08.614878Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}