{"doi":"10.1021/np060291a","title":"Isolation, Structure Elucidation, and Biological Evaluation of 15-Amido-3-demethoxy-2α,3α-methylenedioxyerythroculine, a New Alkaloid from <i>Hyperbaena valida</i>","abstract":null,"journal":"Journal of Natural Products","year":2006,"id":679714,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1775954,"name":"Justin Huffman","orcid":null,"position":1,"is_corresponding":false},{"id":1775955,"name":"Mary D. Menachery","orcid":null,"position":2,"is_corresponding":false},{"id":1775956,"name":"Kristina Huey","orcid":null,"position":3,"is_corresponding":false},{"id":1775957,"name":"William J. Leavens","orcid":null,"position":4,"is_corresponding":false},{"id":1326739,"name":"Richard W. Fitch","orcid":"0000-0002-4927-725X","position":5,"is_corresponding":false},{"id":1775953,"name":"Alan J. Freyer","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Isolation, Structure Elucidation, and Biological Evaluation of 15-Amido-3-demethoxy-2α,3α-methylenedioxyerythroculine, a New Alkaloid from <i>Hyperbaena valida</i>","abstract":"A phytochemical investigation of the leaves of Hyperbaena valida resulted in the isolation and characterization of two erythrina-type alkaloids, 1 and 2, which were found to be antagonists at nicotinic receptors. Compound 1 was assigned as the new 15-amido-3-demethoxy-2alpha,3alpha-methylenedioxyerythroculine and compound 2 as the known 3-demethoxy-2alpha,3alpha-methylenedioxyerythroculine. Antagonism of a 100 microM nicotine response was observed for alkaloid 1 (IC50 value of 94 +/- 8 microM) and alkaloid 2 (IC50 value of 77 +/- 19 microM).","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17067175","pmcid":null,"openalex_id":"https://openalex.org/W1971138718","authors":[],"funders":[],"total_grants":0,"fwci":0.4982,"citation_percentile":0.75566279,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2021,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://doi.org/10.7270/q2445m85","host_type":"repository"},{"url":"https://doi.org/10.7270/q2445m85","host_type":"repository"},{"url":"https://pubs.acs.org/doi/pdf/10.1021/np060291a","host_type":"publisher"},{"url":"https://doi.org/10.1021/np060291a","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17067175","host_type":"repository"}],"fields_of_study":["Botanical Research and Chemistry","Traditional and Medicinal Uses of Annonaceae","Chemical synthesis and alkaloids","Algorithms","Alkaloids","Heterocyclic Compounds, 4 or More Rings","Inhibitory Concentration 50","Jamaica","Menispermaceae","Molecular Structure","Nicotinic Antagonists","Plants, Medicinal"],"mesh_terms":["Algorithms","Alkaloids","Heterocyclic Compounds, 4 or More Rings","Jamaica","Plants, Medicinal","Molecular Structure","Nicotinic Antagonists","Inhibitory Concentration 50","Menispermaceae"],"keywords":["Alkaloid","Stereochemistry","Chemistry","Isolation (microbiology)","Organic chemistry","Biology","Bioinformatics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T13:39:25.546596Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}