{"doi":"10.1021/jp0703758","title":"UV Resonance Raman Measurements of Poly-<scp>l</scp>-Lysine's Conformational Energy Landscapes:  Dependence on Perchlorate Concentration and Temperature","abstract":null,"journal":"The Journal of Physical Chemistry B","year":2007,"id":663043,"datarank":0.5533319181170905,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"self_citation_contribution":0.5533319181170905,"citation_network_contribution":0.0,"self_endowment_contribution":0.5533319181170905,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1028189,"name":"Zeeshan Ahmed","orcid":"0000-0002-3736-3484","position":1,"is_corresponding":false},{"id":1731014,"name":"Aleksandr V. Mikhonin","orcid":null,"position":2,"is_corresponding":false},{"id":1731016,"name":"Sanford A. Asher","orcid":null,"position":3,"is_corresponding":false},{"id":371427,"name":"Lu Ma","orcid":"0000-0002-6265-5032","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"UV Resonance Raman Measurements of Poly-<scp>l</scp>-Lysine's Conformational Energy Landscapes:  Dependence on Perchlorate Concentration and Temperature","abstract":"UV resonance Raman spectroscopy has been used to determine the conformational energy landscape of poly-L-lysine (PLL) in the presence of NaClO4 as a function of temperature. At 1 degree C, in the presence of 0.83 M NaClO4, PLL shows an approximately 86% alpha-helix-like content, which contains alpha-helix and pi-bulge/helix conformations. The high alpha-helix-like content of PLL occurs because of charge screening due to strong ion-pair formation between ClO4- and the lysine side chain -NH3+. As the temperature increases from 1 to 60 degrees C, the alpha-helix and pi-bulge/helix conformations melt into extended conformations (PPII and 2.51-helix). We calculate the Psi Ramachandran angle distribution of the PLL peptide bonds from the UV Raman spectra which allows us to calculate the PLL (un)folding energy landscapes along the Psi reaction coordinate. We observe a basin in the Psi angle conformational space associated with alpha-helix and pi-bulge/helix conformations and another basin for the extended PPII and 2.51-helical conformations.","is_dataset_classified":null,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17567063","pmcid":null,"openalex_id":"https://openalex.org/W2017572970","authors":[],"funders":[{"funder_name":"NIBIB NIH HHS","grant_id":"GM8 R01 EB 002053-24","title":null}],"total_grants":1,"fwci":1.4656,"citation_percentile":0.80503098,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":2},{"year":2014,"count":2},{"year":2015,"count":2},{"year":2017,"count":1},{"year":2019,"count":1},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/jp0703758","host_type":"publisher"},{"url":"https://doi.org/10.1021/jp0703758","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17567063","host_type":"repository"}],"fields_of_study":["Biopolymer Synthesis and Applications","DNA and Nucleic Acid Chemistry","Crystallography and molecular interactions","Circular Dichroism","Perchlorates","Polylysine","Protein Conformation","Protein Folding","Sodium Compounds","Spectrophotometry, Ultraviolet","Spectrum Analysis, Raman","Temperature","Thermodynamics"],"mesh_terms":["Circular Dichroism","Perchlorates","Polylysine","Protein Conformation","Spectrophotometry, Ultraviolet","Spectrum Analysis, Raman","Temperature","Thermodynamics","Protein Folding","Sodium Compounds"],"keywords":["Raman spectroscopy","Perchlorate","Lysine","Resonance (particle physics)","Conformational change","Analytical Chemistry (journal)","Chemistry","Activation energy","Materials science","Ion","Physical chemistry","Optics","Stereochemistry","Physics","Biochemistry","Atomic physics","Chromatography","Organic chemistry","Amino acid"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T19:18:58.877437Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}